Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis
Sepsis is a common and deadly syndrome that despite all the progress in its control, the death rate caused by it is high. Sepsis is a serious problem that needs immediate attention and treatment. This infection, especially if it is caused by bacteria resistant to several drugs, causes high mortality...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-11-01
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| Series: | Open Chemistry |
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| Online Access: | https://doi.org/10.1515/chem-2023-0142 |
| _version_ | 1797435685965135872 |
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| author | Zhou Lei Yao Yanfen Wang Quanzhen Wang Peng Hong Shan Kong Li |
| author_facet | Zhou Lei Yao Yanfen Wang Quanzhen Wang Peng Hong Shan Kong Li |
| author_sort | Zhou Lei |
| collection | DOAJ |
| description | Sepsis is a common and deadly syndrome that despite all the progress in its control, the death rate caused by it is high. Sepsis is a serious problem that needs immediate attention and treatment. This infection, especially if it is caused by bacteria resistant to several drugs, causes high mortality. About two-thirds of sepsis cases occur in hospitalized patients. Several factors such as increasing the age of the population, increasing the duration of chronic diseases, high consumption of antibiotics and corticosteroids, use of mechanical devices and intravascular devices play a role in increasing its incidence. We herein demonstrate the biogenic procedure for the in situ immobilizing gold nanoparticles over lignin (Lig)-modified Fe3O4 magnetic nanoparticles mediated by Cydonia leaf extract (Fe3O4@Lig-Ag NPs) and its catalytic activity on the acetylation of alcohols using acetic anhydride and subsequent biological performances. The successful synthesis of Fe3O4@Lig-Ag NPs was assessed using an array of advanced techniques like field emission scanning electron microscopy, fourier transformed infrared spectroscopy, transmission electron microscopy EDX, elemental mapping, vibrating-sample magnetometer, and X-ray diffraction. Cecal ligation and puncture was used for inducing the sepsis model in rats. Several doses of Fe3O4@Lig-Ag NPs (45, 15, and 5 µg/kg) on oxidant–antioxidant, inflammatory mediators mRNA such as IL-1 and TNF-α, and its effects on the levels of expression were assessed in the kidney, liver, duodenum, lung, and stomach. When septic rats kidney, liver, duodenum, lung, and stomach were compared with those of the control group, it was found that Fe3O4@Lig-Ag NPs dose-dependent administration raised glutathione levels and superoxide dismutase activity and significantly reduced the levels of malondialdehyde. The Fe3O4@Lig-Ag NPs (45 µg/kg) indicated greater anti-oxidative effects than the 5 and 15 µg/kg doses for all the assessed parameters. In addition, the expression of TNF-α mRNA in the CLP + 45 µg/kg group was decreased in comparison with the control group. Fe3O4@Lig-Ag NPs reduced oxidative stress by enhancing the free radicals scavenging effects and supporting endogenous antioxidants. The Fe3O4@Lig-Ag NPs potent antioxidant property may be related to the cytokine cascade suppression during sepsis. The above findings offer that Fe3O4@Lig-Ag NPs administration may indicate a modern treatment for the inhibition of liver, kidney, lung, duodenum, and stomach tissues damage caused by septic conditions. |
| first_indexed | 2024-03-09T10:51:49Z |
| format | Article |
| id | doaj.art-d4cae7c0e5ea4cd6835c9903b25d23b9 |
| institution | Directory Open Access Journal |
| issn | 2391-5420 |
| language | English |
| last_indexed | 2024-03-09T10:51:49Z |
| publishDate | 2023-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj.art-d4cae7c0e5ea4cd6835c9903b25d23b92023-12-01T07:18:14ZengDe GruyterOpen Chemistry2391-54202023-11-0121113081610.1515/chem-2023-0142Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsisZhou Lei0Yao Yanfen1Wang Quanzhen2Wang Peng3Hong Shan4Kong Li5The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250399, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250399, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, 250014, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250399, ChinaDepartment of Pharmacology, Qingdao University, Qingdao, Shandong, 266000, ChinaThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250399, ChinaSepsis is a common and deadly syndrome that despite all the progress in its control, the death rate caused by it is high. Sepsis is a serious problem that needs immediate attention and treatment. This infection, especially if it is caused by bacteria resistant to several drugs, causes high mortality. About two-thirds of sepsis cases occur in hospitalized patients. Several factors such as increasing the age of the population, increasing the duration of chronic diseases, high consumption of antibiotics and corticosteroids, use of mechanical devices and intravascular devices play a role in increasing its incidence. We herein demonstrate the biogenic procedure for the in situ immobilizing gold nanoparticles over lignin (Lig)-modified Fe3O4 magnetic nanoparticles mediated by Cydonia leaf extract (Fe3O4@Lig-Ag NPs) and its catalytic activity on the acetylation of alcohols using acetic anhydride and subsequent biological performances. The successful synthesis of Fe3O4@Lig-Ag NPs was assessed using an array of advanced techniques like field emission scanning electron microscopy, fourier transformed infrared spectroscopy, transmission electron microscopy EDX, elemental mapping, vibrating-sample magnetometer, and X-ray diffraction. Cecal ligation and puncture was used for inducing the sepsis model in rats. Several doses of Fe3O4@Lig-Ag NPs (45, 15, and 5 µg/kg) on oxidant–antioxidant, inflammatory mediators mRNA such as IL-1 and TNF-α, and its effects on the levels of expression were assessed in the kidney, liver, duodenum, lung, and stomach. When septic rats kidney, liver, duodenum, lung, and stomach were compared with those of the control group, it was found that Fe3O4@Lig-Ag NPs dose-dependent administration raised glutathione levels and superoxide dismutase activity and significantly reduced the levels of malondialdehyde. The Fe3O4@Lig-Ag NPs (45 µg/kg) indicated greater anti-oxidative effects than the 5 and 15 µg/kg doses for all the assessed parameters. In addition, the expression of TNF-α mRNA in the CLP + 45 µg/kg group was decreased in comparison with the control group. Fe3O4@Lig-Ag NPs reduced oxidative stress by enhancing the free radicals scavenging effects and supporting endogenous antioxidants. The Fe3O4@Lig-Ag NPs potent antioxidant property may be related to the cytokine cascade suppression during sepsis. The above findings offer that Fe3O4@Lig-Ag NPs administration may indicate a modern treatment for the inhibition of liver, kidney, lung, duodenum, and stomach tissues damage caused by septic conditions.https://doi.org/10.1515/chem-2023-0142cecal ligation and puncture-induced sepsisinflammatory mediatorsacetylationsilver nanoparticlescydonia |
| spellingShingle | Zhou Lei Yao Yanfen Wang Quanzhen Wang Peng Hong Shan Kong Li Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis Open Chemistry cecal ligation and puncture-induced sepsis inflammatory mediators acetylation silver nanoparticles cydonia |
| title | Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis |
| title_full | Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis |
| title_fullStr | Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis |
| title_full_unstemmed | Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis |
| title_short | Effects of green decorated AgNPs on lignin-modified magnetic nanoparticles mediated by Cydonia on cecal ligation and puncture-induced sepsis |
| title_sort | effects of green decorated agnps on lignin modified magnetic nanoparticles mediated by cydonia on cecal ligation and puncture induced sepsis |
| topic | cecal ligation and puncture-induced sepsis inflammatory mediators acetylation silver nanoparticles cydonia |
| url | https://doi.org/10.1515/chem-2023-0142 |
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