Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years)
Abstract Background There is lack of data on effect modification by age on the association between body mass index (BMI) or waist circumference (WC) and cardiovascular diseases (CVDs). We aimed to investigate the impact of BMI and WC on incident CVDs in individuals aged 40 and 66 years. Methods Over...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-02-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.13138 |
| _version_ | 1827267500822233088 |
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| author | Jung Eun Yoo Kyungdo Han Jin‐Hyung Jung Yang‐Im Hur Yang Hyun Kim Eun Sook Kim Jang Won Son Eun‐Jung Rhee Won‐Young Lee Ga Eun Nam |
| author_facet | Jung Eun Yoo Kyungdo Han Jin‐Hyung Jung Yang‐Im Hur Yang Hyun Kim Eun Sook Kim Jang Won Son Eun‐Jung Rhee Won‐Young Lee Ga Eun Nam |
| author_sort | Jung Eun Yoo |
| collection | DOAJ |
| description | Abstract Background There is lack of data on effect modification by age on the association between body mass index (BMI) or waist circumference (WC) and cardiovascular diseases (CVDs). We aimed to investigate the impact of BMI and WC on incident CVDs in individuals aged 40 and 66 years. Methods Overall, 2 430 510 participants who underwent a national health screening for transitional ages provided by the Korean National Health Insurance Service between 2009 and 2012 were included. The adjusted hazard ratios and 95% confidence intervals for myocardial infarction (MI), ischaemic stroke and CVDs as a composite outcome of MI and ischaemic stroke were calculated using multivariable Cox proportional hazard regression analysis. Results During a mean follow‐up of 7.7 years, 24 884 MI and 29 415 ischaemic stroke events occurred. Among participants aged 40 years, there was a J‐shaped association of BMI with incident CVDs, MI and ischaemic stroke with nadir at BMI 18.5–22.9 kg/m2 (P for trend < 0.001 for all). Among those aged 66 years, there were significant U‐shaped associations of BMI with CVDs and MI with nadir at a BMI of 23.0–24.9 kg/m2 (P for trend 0.013 and 0.017, respectively). WC was linearly associated with all study outcomes in both age groups (P for trend < 0.001). The impact of general and abdominal obesity on both study outcomes was more prominent in those aged 40 years than in those aged 66 years (P for interaction < 0.001). Conclusions To prevent cardiovascular risk, weight loss intervention should be cautiously implemented and individualized according to age. The maintenance of muscle mass may be essential in managing weight loss particularly in older population. |
| first_indexed | 2024-03-13T05:54:17Z |
| format | Article |
| id | doaj.art-d4cbc6bb175944febc1cfe1977813834 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2025-03-22T04:34:44Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-d4cbc6bb175944febc1cfe19778138342024-04-28T01:42:47ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092023-02-0114136938110.1002/jcsm.13138Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years)Jung Eun Yoo0Kyungdo Han1Jin‐Hyung Jung2Yang‐Im Hur3Yang Hyun Kim4Eun Sook Kim5Jang Won Son6Eun‐Jung Rhee7Won‐Young Lee8Ga Eun Nam9Department of Family Medicine Healthcare System Gangnam Center Seoul National University Hospital Seoul Republic of KoreaDepartment of Statistics and Actuarial Science Soongsil University Seoul Republic of KoreaDepartment of Biostatistics, College of Medicine The Catholic University of Korea Seoul Republic of KoreaDepartment of Family Medicine, CHA Bundang Medical Center CHA University Seongnam Republic of KoreaDepartment of Family Medicine Korea University College of Medicine Seoul Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine The Catholic University of Korea Incheon Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Bucheon St. Mary's Hospital, College of Medicine The Catholic University of Korea Bucheon Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Republic of KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Republic of KoreaDepartment of Family Medicine Korea University College of Medicine Seoul Republic of KoreaAbstract Background There is lack of data on effect modification by age on the association between body mass index (BMI) or waist circumference (WC) and cardiovascular diseases (CVDs). We aimed to investigate the impact of BMI and WC on incident CVDs in individuals aged 40 and 66 years. Methods Overall, 2 430 510 participants who underwent a national health screening for transitional ages provided by the Korean National Health Insurance Service between 2009 and 2012 were included. The adjusted hazard ratios and 95% confidence intervals for myocardial infarction (MI), ischaemic stroke and CVDs as a composite outcome of MI and ischaemic stroke were calculated using multivariable Cox proportional hazard regression analysis. Results During a mean follow‐up of 7.7 years, 24 884 MI and 29 415 ischaemic stroke events occurred. Among participants aged 40 years, there was a J‐shaped association of BMI with incident CVDs, MI and ischaemic stroke with nadir at BMI 18.5–22.9 kg/m2 (P for trend < 0.001 for all). Among those aged 66 years, there were significant U‐shaped associations of BMI with CVDs and MI with nadir at a BMI of 23.0–24.9 kg/m2 (P for trend 0.013 and 0.017, respectively). WC was linearly associated with all study outcomes in both age groups (P for trend < 0.001). The impact of general and abdominal obesity on both study outcomes was more prominent in those aged 40 years than in those aged 66 years (P for interaction < 0.001). Conclusions To prevent cardiovascular risk, weight loss intervention should be cautiously implemented and individualized according to age. The maintenance of muscle mass may be essential in managing weight loss particularly in older population.https://doi.org/10.1002/jcsm.13138body mass indexcardiovascular diseaseischaemic strokemiddle agemyocardial infarctionold age |
| spellingShingle | Jung Eun Yoo Kyungdo Han Jin‐Hyung Jung Yang‐Im Hur Yang Hyun Kim Eun Sook Kim Jang Won Son Eun‐Jung Rhee Won‐Young Lee Ga Eun Nam Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years) Journal of Cachexia, Sarcopenia and Muscle body mass index cardiovascular disease ischaemic stroke middle age myocardial infarction old age |
| title | Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years) |
| title_full | Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years) |
| title_fullStr | Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years) |
| title_full_unstemmed | Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years) |
| title_short | Body mass index, waist circumference and cardiovascular diseases in transitional ages (40 and 66 years) |
| title_sort | body mass index waist circumference and cardiovascular diseases in transitional ages 40 and 66 years |
| topic | body mass index cardiovascular disease ischaemic stroke middle age myocardial infarction old age |
| url | https://doi.org/10.1002/jcsm.13138 |
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