Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment
Abstract The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2024-03-01
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| Series: | Journal of Materials Science: Materials in Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s10856-024-06786-y |
| _version_ | 1797233857131446272 |
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| author | Jing Wang Yisheng Yin Xiang Ren Shaogang Wang Yunpeng Zhu |
| author_facet | Jing Wang Yisheng Yin Xiang Ren Shaogang Wang Yunpeng Zhu |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Abstract The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues. Mechanically, the GEM and CDDP-loaded electrospun nanocomposites could effectively eliminate myeloid-derived suppressor cells (MDSCs) in tumor tissues, and recruit CD8+ T cells and NKp46+ NK cells to kill tumor cells, which can also effectively inhibit tumor microvascular formation. Our investigation into the impact of localized administration of chemotherapy through GEM and CDDP-loaded electrospun nanocomposites on the tumor microenvironment will offer novel insights for tackling tumors. Graphical abstract Drug-loaded electrospun nanofibrous mats suppress bladder tumor growth by improving the tumor immune microenvironment. |
| first_indexed | 2024-04-24T16:22:50Z |
| format | Article |
| id | doaj.art-d4cec867997245fe9a710b0848f9493a |
| institution | Directory Open Access Journal |
| issn | 1573-4838 |
| language | English |
| last_indexed | 2024-04-24T16:22:50Z |
| publishDate | 2024-03-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj.art-d4cec867997245fe9a710b0848f9493a2024-03-31T11:09:33ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382024-03-0135111310.1007/s10856-024-06786-yElectrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironmentJing Wang0Yisheng Yin1Xiang Ren2Shaogang Wang3Yunpeng Zhu4Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract The perplexing issues related to positive surgical margins and the considerable negative consequences associated with systemic chemotherapy have posed ongoing challenges for clinicians, especially when it comes to addressing bladder cancer treatment. The current investigation describes the production of nanocomposites loaded with gemcitabine (GEM) and cisplatin (CDDP) through the utilization of electrospinning technology. In vitro and in vivo studies have provided evidence of the strong effectiveness in suppressing tumor advancement while simultaneously reducing the accumulation of chemotherapy drugs within liver and kidney tissues. Mechanically, the GEM and CDDP-loaded electrospun nanocomposites could effectively eliminate myeloid-derived suppressor cells (MDSCs) in tumor tissues, and recruit CD8+ T cells and NKp46+ NK cells to kill tumor cells, which can also effectively inhibit tumor microvascular formation. Our investigation into the impact of localized administration of chemotherapy through GEM and CDDP-loaded electrospun nanocomposites on the tumor microenvironment will offer novel insights for tackling tumors. Graphical abstract Drug-loaded electrospun nanofibrous mats suppress bladder tumor growth by improving the tumor immune microenvironment.https://doi.org/10.1007/s10856-024-06786-yElectrostatic spinningBladder cancerPositive surgical marginsTopical chemotherapyTumor microenvironment |
| spellingShingle | Jing Wang Yisheng Yin Xiang Ren Shaogang Wang Yunpeng Zhu Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment Journal of Materials Science: Materials in Medicine Electrostatic spinning Bladder cancer Positive surgical margins Topical chemotherapy Tumor microenvironment |
| title | Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment |
| title_full | Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment |
| title_fullStr | Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment |
| title_full_unstemmed | Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment |
| title_short | Electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment |
| title_sort | electrospun nanofibrous mats loaded with gemcitabine and cisplatin suppress bladder tumor growth by improving the tumor immune microenvironment |
| topic | Electrostatic spinning Bladder cancer Positive surgical margins Topical chemotherapy Tumor microenvironment |
| url | https://doi.org/10.1007/s10856-024-06786-y |
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