ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction

ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction

Abstract Aims The prevalence of heart failure with preserved ejection fraction (HFpEF) is still increasing, and so far, no pharmaceutical treatment has proven to be effective. A key obstacle for testing new pharmaceutical substances is the availability of suitable animal models for HFpEF, which real...

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Bibliographic Details
Main Authors: Antje Schauer, Runa Draskowski, Anett Jannasch, Virginia Kirchhoff, Keita Goto, Anita Männel, Peggy Barthel, Antje Augstein, Ephraim Winzer, Malte Tugtekin, Siegfried Labeit, Axel Linke, Volker Adams
Format: Article
Language:English
Published: Wiley 2020-10-01
Series:ESC Heart Failure
Subjects:
ZSF1 rat
Heart failure with preserved ejection fraction
Diastolic dysfunction
Skeletal muscle
Online Access:https://doi.org/10.1002/ehf2.12915

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