Clinical profile of hemophilia patients in Jodhpur Region
Background: Hemophilia is widely distributed all over the world, but little is known about its clinical profile in resource-limited regions. An insight into its clinical spectrum will help in the formulation of policies to improve the situation in these areas. Aims: To study the clinical profile of...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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Series: | Asian Journal of Transfusion Science |
Subjects: | |
Online Access: | http://www.ajts.org/article.asp?issn=0973-6247;year=2016;volume=10;issue=1;spage=101;epage=104;aulast=Payal |
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author | Vikas Payal Pramod Sharma Vishnu Goyal Rakesh Jora Manish Parakh Deepika Payal |
author_facet | Vikas Payal Pramod Sharma Vishnu Goyal Rakesh Jora Manish Parakh Deepika Payal |
author_sort | Vikas Payal |
collection | DOAJ |
description | Background: Hemophilia is widely distributed all over the world, but little is known about its clinical profile in resource-limited regions. An insight into its clinical spectrum will help in the formulation of policies to improve the situation in these areas. Aims: To study the clinical profile of hemophiliacs (age <18 years) in Jodhpur region and screen them for transfusion-transmitted infections. Materials and Methods: A cross-sectional study conducted in the Department of Pediatrics, Umaid Hospital, Dr. S. N. Medical College, Jodhpur, over a period of 12 months. Result: Out of a total of 56 cases enrolled, 51 (91%) cases were diagnosed as hemophilia A while 5 (9%) were diagnosed as hemophilia B. Positive family history was found in 26 (46%) cases. According to their factor levels, 25 (44%) cases had severe disease, 20 (36%) had moderate disease, and 11 (20%) had mild disease. The mean age of onset of symptoms and diagnosis was 1.73 ± 1.43 and 3.87 ± 3.84 years, respectively. First clinical presentation was posttraumatic bleed in 20 (36%), gum bleeds in 17 (30%), epistaxis in 4 (7%), joint bleeds in 4 (7%), skin bleeds in 4 (7%), and circumcision bleed in 3 (5%) cases. Knee joint was the predominant joint affected by hemarthrosis in 38 (68%), followed by ankle in 29 (52%), elbow in 20 (36%), and hip joint in 7 (13%) cases. All patients had a negative screening test for transfusion-transmitted infections. Conclusion: Occurrence of posttraumatic bleeds and gum bleeds in an otherwise normal child should warn the clinician for evaluation of hemophilia. |
first_indexed | 2024-04-13T21:40:17Z |
format | Article |
id | doaj.art-d4d1229069424489845454bd3ff9cd9a |
institution | Directory Open Access Journal |
issn | 0973-6247 1998-3565 |
language | English |
last_indexed | 2024-04-13T21:40:17Z |
publishDate | 2016-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Asian Journal of Transfusion Science |
spelling | doaj.art-d4d1229069424489845454bd3ff9cd9a2022-12-22T02:28:47ZengWolters Kluwer Medknow PublicationsAsian Journal of Transfusion Science0973-62471998-35652016-01-0110110110410.4103/0973-6247.164269Clinical profile of hemophilia patients in Jodhpur RegionVikas PayalPramod SharmaVishnu GoyalRakesh JoraManish ParakhDeepika PayalBackground: Hemophilia is widely distributed all over the world, but little is known about its clinical profile in resource-limited regions. An insight into its clinical spectrum will help in the formulation of policies to improve the situation in these areas. Aims: To study the clinical profile of hemophiliacs (age <18 years) in Jodhpur region and screen them for transfusion-transmitted infections. Materials and Methods: A cross-sectional study conducted in the Department of Pediatrics, Umaid Hospital, Dr. S. N. Medical College, Jodhpur, over a period of 12 months. Result: Out of a total of 56 cases enrolled, 51 (91%) cases were diagnosed as hemophilia A while 5 (9%) were diagnosed as hemophilia B. Positive family history was found in 26 (46%) cases. According to their factor levels, 25 (44%) cases had severe disease, 20 (36%) had moderate disease, and 11 (20%) had mild disease. The mean age of onset of symptoms and diagnosis was 1.73 ± 1.43 and 3.87 ± 3.84 years, respectively. First clinical presentation was posttraumatic bleed in 20 (36%), gum bleeds in 17 (30%), epistaxis in 4 (7%), joint bleeds in 4 (7%), skin bleeds in 4 (7%), and circumcision bleed in 3 (5%) cases. Knee joint was the predominant joint affected by hemarthrosis in 38 (68%), followed by ankle in 29 (52%), elbow in 20 (36%), and hip joint in 7 (13%) cases. All patients had a negative screening test for transfusion-transmitted infections. Conclusion: Occurrence of posttraumatic bleeds and gum bleeds in an otherwise normal child should warn the clinician for evaluation of hemophilia.http://www.ajts.org/article.asp?issn=0973-6247;year=2016;volume=10;issue=1;spage=101;epage=104;aulast=PayalClinical manifestationhemarthrosishemophilia |
spellingShingle | Vikas Payal Pramod Sharma Vishnu Goyal Rakesh Jora Manish Parakh Deepika Payal Clinical profile of hemophilia patients in Jodhpur Region Asian Journal of Transfusion Science Clinical manifestation hemarthrosis hemophilia |
title | Clinical profile of hemophilia patients in Jodhpur Region |
title_full | Clinical profile of hemophilia patients in Jodhpur Region |
title_fullStr | Clinical profile of hemophilia patients in Jodhpur Region |
title_full_unstemmed | Clinical profile of hemophilia patients in Jodhpur Region |
title_short | Clinical profile of hemophilia patients in Jodhpur Region |
title_sort | clinical profile of hemophilia patients in jodhpur region |
topic | Clinical manifestation hemarthrosis hemophilia |
url | http://www.ajts.org/article.asp?issn=0973-6247;year=2016;volume=10;issue=1;spage=101;epage=104;aulast=Payal |
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