The Role of Apolipoproteins in the Commonest Cancers: A Review
Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the onset of a variety of human cancers; however, the role of certain APOs in cancer...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-11-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/23/5565 |
| _version_ | 1797400416574504960 |
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| author | Nour M. Darwish Mooza Kh. Al-Hail Youssef Mohamed Rafif Al Saady Sara Mohsen Amna Zar Layla Al-Mansoori Shona Pedersen |
| author_facet | Nour M. Darwish Mooza Kh. Al-Hail Youssef Mohamed Rafif Al Saady Sara Mohsen Amna Zar Layla Al-Mansoori Shona Pedersen |
| author_sort | Nour M. Darwish |
| collection | DOAJ |
| description | Apolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the onset of a variety of human cancers; however, the role of certain APOs in cancer development remains unknown. Based on recent work, we hypothesize that APOs might be involved in the onset of cancer, with a focus on the most common cancers, including breast, lung, gynecological, colorectal, thyroid, gastric, pancreatic, hepatic, and prostate cancers. This review will focus on the evidence supporting this hypothesis, the mechanisms linking APOs to the onset of cancer, and the potential clinical relevance of its various inhibitors. |
| first_indexed | 2024-03-09T01:54:14Z |
| format | Article |
| id | doaj.art-d4d1c3e7c85f478a98edb2fd6e1dca2b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T01:54:14Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-d4d1c3e7c85f478a98edb2fd6e1dca2b2023-12-08T15:12:34ZengMDPI AGCancers2072-66942023-11-011523556510.3390/cancers15235565The Role of Apolipoproteins in the Commonest Cancers: A ReviewNour M. Darwish0Mooza Kh. Al-Hail1Youssef Mohamed2Rafif Al Saady3Sara Mohsen4Amna Zar5Layla Al-Mansoori6Shona Pedersen7College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarBiomedical Research Center, Qatar University, Doha P.O. Box 2713, QatarCollege of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarApolipoproteins (APOs) are vital structural components of plasma lipoproteins that are involved in lipid metabolism and transport. Recent studies have reported an association between apolipoprotein dysregulation and the onset of a variety of human cancers; however, the role of certain APOs in cancer development remains unknown. Based on recent work, we hypothesize that APOs might be involved in the onset of cancer, with a focus on the most common cancers, including breast, lung, gynecological, colorectal, thyroid, gastric, pancreatic, hepatic, and prostate cancers. This review will focus on the evidence supporting this hypothesis, the mechanisms linking APOs to the onset of cancer, and the potential clinical relevance of its various inhibitors.https://www.mdpi.com/2072-6694/15/23/5565apolipoproteinscarcinogenesisgene expressiontherapeutics |
| spellingShingle | Nour M. Darwish Mooza Kh. Al-Hail Youssef Mohamed Rafif Al Saady Sara Mohsen Amna Zar Layla Al-Mansoori Shona Pedersen The Role of Apolipoproteins in the Commonest Cancers: A Review Cancers apolipoproteins carcinogenesis gene expression therapeutics |
| title | The Role of Apolipoproteins in the Commonest Cancers: A Review |
| title_full | The Role of Apolipoproteins in the Commonest Cancers: A Review |
| title_fullStr | The Role of Apolipoproteins in the Commonest Cancers: A Review |
| title_full_unstemmed | The Role of Apolipoproteins in the Commonest Cancers: A Review |
| title_short | The Role of Apolipoproteins in the Commonest Cancers: A Review |
| title_sort | role of apolipoproteins in the commonest cancers a review |
| topic | apolipoproteins carcinogenesis gene expression therapeutics |
| url | https://www.mdpi.com/2072-6694/15/23/5565 |
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