Mucosal IgG in inflammatory bowel disease – a question of (sub)class?
Immunoglobulins (Igs) form a cornerstone of mucosal immunity. In the gastrointestinal tract, secretory IgA and IgM bind to commensal microorganisms within the intestinal lumen to prevent them from breaching the intestinal epithelium – a process known as immune exclusion. In recent years, there has b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-11-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/19490976.2019.1651596 |
| _version_ | 1818878648904581120 |
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| author | Tomas Castro-Dopico Menna R. Clatworthy |
| author_facet | Tomas Castro-Dopico Menna R. Clatworthy |
| author_sort | Tomas Castro-Dopico |
| collection | DOAJ |
| description | Immunoglobulins (Igs) form a cornerstone of mucosal immunity. In the gastrointestinal tract, secretory IgA and IgM bind to commensal microorganisms within the intestinal lumen to prevent them from breaching the intestinal epithelium – a process known as immune exclusion. In recent years, there has been renewed interest in the role of IgG in intestinal immunity, driven in part by a genetic association of an affinity-lowering variant of an IgG receptor, FcγRIIA, with protection from ulcerative colitis (UC), a subclass of inflammatory bowel disease (IBD). We recently demonstrated a role for IgG and Fcγ receptor signalling in driving pathogenic IL-1β production by colonic mononuclear phagocytes and the subsequent induction of a local type 17 response in UC. Here, we discuss the potential relevance of our observations to the other major subclass of IBD – Crohn’s disease (CD) – where the genetic association with FCGR variants is less robust and consider how this may impact therapeutic interventions in these disease subsets. |
| first_indexed | 2024-12-19T14:17:32Z |
| format | Article |
| id | doaj.art-d4d2647e41614b289459fe18dc691a73 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-12-19T14:17:32Z |
| publishDate | 2020-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-d4d2647e41614b289459fe18dc691a732022-12-21T20:17:56ZengTaylor & Francis GroupGut Microbes1949-09761949-09842020-11-0112110.1080/19490976.2019.16515961651596Mucosal IgG in inflammatory bowel disease – a question of (sub)class?Tomas Castro-Dopico0Menna R. Clatworthy1University of CambridgeUniversity of CambridgeImmunoglobulins (Igs) form a cornerstone of mucosal immunity. In the gastrointestinal tract, secretory IgA and IgM bind to commensal microorganisms within the intestinal lumen to prevent them from breaching the intestinal epithelium – a process known as immune exclusion. In recent years, there has been renewed interest in the role of IgG in intestinal immunity, driven in part by a genetic association of an affinity-lowering variant of an IgG receptor, FcγRIIA, with protection from ulcerative colitis (UC), a subclass of inflammatory bowel disease (IBD). We recently demonstrated a role for IgG and Fcγ receptor signalling in driving pathogenic IL-1β production by colonic mononuclear phagocytes and the subsequent induction of a local type 17 response in UC. Here, we discuss the potential relevance of our observations to the other major subclass of IBD – Crohn’s disease (CD) – where the genetic association with FCGR variants is less robust and consider how this may impact therapeutic interventions in these disease subsets.http://dx.doi.org/10.1080/19490976.2019.1651596iggfcγ receptorsinflammatory bowel diseaseulcerative colitiscrohn’s diseasesubclasses |
| spellingShingle | Tomas Castro-Dopico Menna R. Clatworthy Mucosal IgG in inflammatory bowel disease – a question of (sub)class? Gut Microbes igg fcγ receptors inflammatory bowel disease ulcerative colitis crohn’s disease subclasses |
| title | Mucosal IgG in inflammatory bowel disease – a question of (sub)class? |
| title_full | Mucosal IgG in inflammatory bowel disease – a question of (sub)class? |
| title_fullStr | Mucosal IgG in inflammatory bowel disease – a question of (sub)class? |
| title_full_unstemmed | Mucosal IgG in inflammatory bowel disease – a question of (sub)class? |
| title_short | Mucosal IgG in inflammatory bowel disease – a question of (sub)class? |
| title_sort | mucosal igg in inflammatory bowel disease a question of sub class |
| topic | igg fcγ receptors inflammatory bowel disease ulcerative colitis crohn’s disease subclasses |
| url | http://dx.doi.org/10.1080/19490976.2019.1651596 |
| work_keys_str_mv | AT tomascastrodopico mucosaliggininflammatoryboweldiseaseaquestionofsubclass AT mennarclatworthy mucosaliggininflammatoryboweldiseaseaquestionofsubclass |