Comparison of Paravertebral Plane Block for Post-Operative Analgesia in Modified Radical Mastectomy with Intravenous Nalbuphine
Objective: To compare the post-operative analgesic efficacy and adverse effect profile of ultrasound-guided paravertebral plane block with intravenous Nalbuphine in patients with breast cancer planned for modified radical mastectomy. Study Design: Quasi-experimental study. Place and Duration o...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-10-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/PAFMJ/article/view/9754 |
| _version_ | 1797341038344404992 |
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| author | Abdullah Sher Kakar Amran Hafiz Nabeel Tahir Butt Syed Qasim Ali Shah Afsa Nayyar Muhammad Ahmed Raza |
| author_facet | Abdullah Sher Kakar Amran Hafiz Nabeel Tahir Butt Syed Qasim Ali Shah Afsa Nayyar Muhammad Ahmed Raza |
| author_sort | Abdullah Sher Kakar |
| collection | DOAJ |
| description |
Objective: To compare the post-operative analgesic efficacy and adverse effect profile of ultrasound-guided paravertebral
plane block with intravenous Nalbuphine in patients with breast cancer planned for modified radical mastectomy.
Study Design: Quasi-experimental study.
Place and Duration of Study: Anesthesia Department Combined Military Hospital, Rawalpindi Pakistan, from Jun to Dec
2022.
Methodology: A total of 106 patients diagnosed with breast cancer Stage I and II requiring modified radical mastectomy were included. Comparison of the post-operative analgesic efficacy and adverse effect profile of ultrasound-guided paravertebral plane block and intravenous Nalbuphine were noted.
Results: One hundred six patients were included in the study, and divided into the Nalbuphine Group (n=53) and the
Paravertebral Block (PVB) Group (n=53). The per-operative Nalbuphine requirement was significantly reduced in the PVBGroup, 2.28±0.37 mg versus 5.30±0.24 mg in the Nalbuphine-Group (p<0.001). Similarly, the time to the first dose of rescue analgesia was significantly prolonged in the PVB Group at 238.32±5.22 minutes versus 37.71±1.72 minutes in the Nalbuphine Group. The mean satisfaction score between both Groups was 4.33±0.64 in the Nalbuphine was 5.69±0.66 and in the PVB Group (p<0.001).
Conclusion: We conclude that paravertebral block is superior to intravenous opioids in decreasing the per-operative and postoperative dose of intravenous opioids with a more favourable profile and a decreased incidence of adverse events.
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| first_indexed | 2024-03-08T10:12:07Z |
| format | Article |
| id | doaj.art-d4d2fd8b8cb141fb82a435b058d65ef2 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-03-08T10:12:07Z |
| publishDate | 2023-10-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-d4d2fd8b8cb141fb82a435b058d65ef22024-01-29T08:26:30ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-10-0173510.51253/pafmj.v73i5.9754Comparison of Paravertebral Plane Block for Post-Operative Analgesia in Modified Radical Mastectomy with Intravenous NalbuphineAbdullah Sher Kakar0Amran Hafiz1Nabeel Tahir Butt 2Syed Qasim Ali Shah3Afsa Nayyar4Muhammad Ahmed Raza5Department of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Anesthesia, Pak Emirates Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Surgery, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanDepartment of Anesthesia, Combined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi Pakistan Objective: To compare the post-operative analgesic efficacy and adverse effect profile of ultrasound-guided paravertebral plane block with intravenous Nalbuphine in patients with breast cancer planned for modified radical mastectomy. Study Design: Quasi-experimental study. Place and Duration of Study: Anesthesia Department Combined Military Hospital, Rawalpindi Pakistan, from Jun to Dec 2022. Methodology: A total of 106 patients diagnosed with breast cancer Stage I and II requiring modified radical mastectomy were included. Comparison of the post-operative analgesic efficacy and adverse effect profile of ultrasound-guided paravertebral plane block and intravenous Nalbuphine were noted. Results: One hundred six patients were included in the study, and divided into the Nalbuphine Group (n=53) and the Paravertebral Block (PVB) Group (n=53). The per-operative Nalbuphine requirement was significantly reduced in the PVBGroup, 2.28±0.37 mg versus 5.30±0.24 mg in the Nalbuphine-Group (p<0.001). Similarly, the time to the first dose of rescue analgesia was significantly prolonged in the PVB Group at 238.32±5.22 minutes versus 37.71±1.72 minutes in the Nalbuphine Group. The mean satisfaction score between both Groups was 4.33±0.64 in the Nalbuphine was 5.69±0.66 and in the PVB Group (p<0.001). Conclusion: We conclude that paravertebral block is superior to intravenous opioids in decreasing the per-operative and postoperative dose of intravenous opioids with a more favourable profile and a decreased incidence of adverse events. https://www.pafmj.org/PAFMJ/article/view/9754AnalgesiaModified radical mastectomyNalbuphineParavertebral block |
| spellingShingle | Abdullah Sher Kakar Amran Hafiz Nabeel Tahir Butt Syed Qasim Ali Shah Afsa Nayyar Muhammad Ahmed Raza Comparison of Paravertebral Plane Block for Post-Operative Analgesia in Modified Radical Mastectomy with Intravenous Nalbuphine Pakistan Armed Forces Medical Journal Analgesia Modified radical mastectomy Nalbuphine Paravertebral block |
| title | Comparison of Paravertebral Plane Block for Post-Operative Analgesia in Modified Radical Mastectomy with Intravenous Nalbuphine |
| title_full | Comparison of Paravertebral Plane Block for Post-Operative Analgesia in Modified Radical Mastectomy with Intravenous Nalbuphine |
| title_fullStr | Comparison of Paravertebral Plane Block for Post-Operative Analgesia in Modified Radical Mastectomy with Intravenous Nalbuphine |
| title_full_unstemmed | Comparison of Paravertebral Plane Block for Post-Operative Analgesia in Modified Radical Mastectomy with Intravenous Nalbuphine |
| title_short | Comparison of Paravertebral Plane Block for Post-Operative Analgesia in Modified Radical Mastectomy with Intravenous Nalbuphine |
| title_sort | comparison of paravertebral plane block for post operative analgesia in modified radical mastectomy with intravenous nalbuphine |
| topic | Analgesia Modified radical mastectomy Nalbuphine Paravertebral block |
| url | https://www.pafmj.org/PAFMJ/article/view/9754 |
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