Treatment of hepatitis C virus genotype 4 in the DAA era
Abstract The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most hepatitis C virus (HCV) infected patients. Nevertheless HCV genotypes are differ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-11-01
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| Series: | Virology Journal |
| Online Access: | http://link.springer.com/article/10.1186/s12985-018-1094-4 |
| _version_ | 1819092908658130944 |
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| author | Antonio Di Biagio Lucia Taramasso Giovanni Cenderello |
| author_facet | Antonio Di Biagio Lucia Taramasso Giovanni Cenderello |
| author_sort | Antonio Di Biagio |
| collection | DOAJ |
| description | Abstract The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most hepatitis C virus (HCV) infected patients. Nevertheless HCV genotypes are different and only a small percentage of trials consider genotype 4 (GT4), which was associated with lower rates of SVR compared with other genotypes before the arrival of the DAA’s. In this review, we discuss the efficacy of DAA therapy in GT4 HCV infection with specific reference to more recent studies, including those conducted in a ‘field-practice’ scenario. Overall, DAA-based regimens appear more effective also in the poorly-explored setting of patients with HCV GT4 infection. Despite an overall limited number of patients was evaluated, favorable results are being derived from studies on ombitasvir/paritaprevir/ritonavir, sofosbuvir and velpatasvir, whether or not in association with voxilaprevir, and with the new combined therapy glecaprevir + pibentasvir. |
| first_indexed | 2024-12-21T23:03:06Z |
| format | Article |
| id | doaj.art-d4d40494971c409daafeebbebcf30cf3 |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-21T23:03:06Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-d4d40494971c409daafeebbebcf30cf32022-12-21T18:47:15ZengBMCVirology Journal1743-422X2018-11-011511810.1186/s12985-018-1094-4Treatment of hepatitis C virus genotype 4 in the DAA eraAntonio Di Biagio0Lucia Taramasso1Giovanni Cenderello2Infectious Diseases Clinic, Policlinico Hospital San MartinoDepartment of Health Sciences (DISSAL), University of Genova and Infectious Disease ClinicInfectious Disease Unit, EO Ospedali GallieraAbstract The recently approved interferon-free DAA (direct antiviral agents) regimens have shown not only to be effective in terms of sustained virological response (SVR) rates (> 90%) but also well tolerated in most hepatitis C virus (HCV) infected patients. Nevertheless HCV genotypes are different and only a small percentage of trials consider genotype 4 (GT4), which was associated with lower rates of SVR compared with other genotypes before the arrival of the DAA’s. In this review, we discuss the efficacy of DAA therapy in GT4 HCV infection with specific reference to more recent studies, including those conducted in a ‘field-practice’ scenario. Overall, DAA-based regimens appear more effective also in the poorly-explored setting of patients with HCV GT4 infection. Despite an overall limited number of patients was evaluated, favorable results are being derived from studies on ombitasvir/paritaprevir/ritonavir, sofosbuvir and velpatasvir, whether or not in association with voxilaprevir, and with the new combined therapy glecaprevir + pibentasvir.http://link.springer.com/article/10.1186/s12985-018-1094-4 |
| spellingShingle | Antonio Di Biagio Lucia Taramasso Giovanni Cenderello Treatment of hepatitis C virus genotype 4 in the DAA era Virology Journal |
| title | Treatment of hepatitis C virus genotype 4 in the DAA era |
| title_full | Treatment of hepatitis C virus genotype 4 in the DAA era |
| title_fullStr | Treatment of hepatitis C virus genotype 4 in the DAA era |
| title_full_unstemmed | Treatment of hepatitis C virus genotype 4 in the DAA era |
| title_short | Treatment of hepatitis C virus genotype 4 in the DAA era |
| title_sort | treatment of hepatitis c virus genotype 4 in the daa era |
| url | http://link.springer.com/article/10.1186/s12985-018-1094-4 |
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