A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash
Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by excessive activation of lymphocytes and macrophages, leading to cytokine storm. Infection-associated HLH is most common, and Epstein-Barr virus is the leading triggers. Quick diagnosis is essential for starting the tr...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Pediatric Emergency Medicine
2019-06-01
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| Series: | Pediatric Emergency Medicine Journal |
| Subjects: | |
| Online Access: | http://pemj.org/upload/pdf/pemj-2018-00297.pdf |
| _version_ | 1827973160016805888 |
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| author | Seong-Beom Oh Chan-Young Koh |
| author_facet | Seong-Beom Oh Chan-Young Koh |
| author_sort | Seong-Beom Oh |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by excessive activation of lymphocytes and macrophages, leading to cytokine storm. Infection-associated HLH is most common, and Epstein-Barr virus is the leading triggers. Quick diagnosis is essential for starting the treatment before irreversible damage. We report a case of 16-year-old boy who presented with unremitted fever, jaundice, and erythematous maculopapular rash all over the body. Investigations showed thrombocytopenia, hyperferritinemia, hypertriglycemia, and the bone marrow biopsy showed hemophagocytosis. Epstein-Barr virus antibody was positive. He responded to chemotherapy as per the HLH-2004 protocol and supportive treatment, and was discharged without complication on day 17. |
| first_indexed | 2024-04-09T19:31:24Z |
| format | Article |
| id | doaj.art-d4d69d904c1c4ecdb5fb0e39ec13678b |
| institution | Directory Open Access Journal |
| issn | 2383-4897 2508-5506 |
| language | English |
| last_indexed | 2024-04-09T19:31:24Z |
| publishDate | 2019-06-01 |
| publisher | Korean Society of Pediatric Emergency Medicine |
| record_format | Article |
| series | Pediatric Emergency Medicine Journal |
| spelling | doaj.art-d4d69d904c1c4ecdb5fb0e39ec13678b2023-04-04T23:49:01ZengKorean Society of Pediatric Emergency MedicinePediatric Emergency Medicine Journal2383-48972508-55062019-06-0161263010.22470/pemj.2018.0029776A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rashSeong-Beom Oh0Chan-Young Koh1Department of Emergency Medicine, Dankook University College of Medicine, Cheonan, KoreaDepartment of Emergency Medicine, Dankook University College of Medicine, Cheonan, KoreaHemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by excessive activation of lymphocytes and macrophages, leading to cytokine storm. Infection-associated HLH is most common, and Epstein-Barr virus is the leading triggers. Quick diagnosis is essential for starting the treatment before irreversible damage. We report a case of 16-year-old boy who presented with unremitted fever, jaundice, and erythematous maculopapular rash all over the body. Investigations showed thrombocytopenia, hyperferritinemia, hypertriglycemia, and the bone marrow biopsy showed hemophagocytosis. Epstein-Barr virus antibody was positive. He responded to chemotherapy as per the HLH-2004 protocol and supportive treatment, and was discharged without complication on day 17.http://pemj.org/upload/pdf/pemj-2018-00297.pdfepstein-barr virus infectionsexanthemaferritinsfeverlymphohistiocytosis, hemophagocytic |
| spellingShingle | Seong-Beom Oh Chan-Young Koh A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash Pediatric Emergency Medicine Journal epstein-barr virus infections exanthema ferritins fever lymphohistiocytosis, hemophagocytic |
| title | A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash |
| title_full | A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash |
| title_fullStr | A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash |
| title_full_unstemmed | A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash |
| title_short | A case of hemophagocytic lymphohistiocytosis caused by an Epstein-Barr virus infection, presenting with unremitting fever and rash |
| title_sort | case of hemophagocytic lymphohistiocytosis caused by an epstein barr virus infection presenting with unremitting fever and rash |
| topic | epstein-barr virus infections exanthema ferritins fever lymphohistiocytosis, hemophagocytic |
| url | http://pemj.org/upload/pdf/pemj-2018-00297.pdf |
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