Bioorthogonal Engineered Virus-Like Nanoparticles for Efficient Gene Therapy

Bioorthogonal Engineered Virus-Like Nanoparticles for Efficient Gene Therapy

Highlights A virus-like nanoparticle (reBiosome) was developed via site-specific codon mutation for displaying unnatural amino acid (Azi) on virus envelope protein at a rational site, followed by conjugating weak acid-responsive polyethylene glycol polymer on Azi via bioorthogonal chemistry. The reB...

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Bibliographic Details
Main Authors: Chun-Jie Bao, Jia-Lun Duan, Ying Xie, Xin-Ping Feng, Wei Cui, Song-Yue Chen, Pei-Shan Li, Yi-Xuan Liu, Jin-Ling Wang, Gui-Ling Wang, Wan-Liang Lu
Format: Article
Language:English
Published: SpringerOpen 2023-08-01
Series:Nano-Micro Letters
Subjects:
Virus-like nanoparticle
Site-specific codon mutation
Recombinant biosome
Bioorthogonal chemistry
Gene therapy
Online Access:https://doi.org/10.1007/s40820-023-01153-y

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