Chronic obstructive pulmonary disease does not impair responses to resistance training
Abstract Background Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of ana...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-07-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-021-02969-1 |
| _version_ | 1831655830835953664 |
|---|---|
| author | Knut Sindre Mølmen Daniel Hammarström Gunnar Slettaløkken Falch Morten Grundtvig Lise Koll Marita Hanestadhaugen Yusuf Khan Rafi Ahmad Bente Malerbakken Tore Jørgen Rødølen Roger Lien Bent R. Rønnestad Truls Raastad Stian Ellefsen |
| author_facet | Knut Sindre Mølmen Daniel Hammarström Gunnar Slettaløkken Falch Morten Grundtvig Lise Koll Marita Hanestadhaugen Yusuf Khan Rafi Ahmad Bente Malerbakken Tore Jørgen Rødølen Roger Lien Bent R. Rønnestad Truls Raastad Stian Ellefsen |
| author_sort | Knut Sindre Mølmen |
| collection | DOAJ |
| description | Abstract Background Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach. Methods Subjects with COPD (n = 20, GOLD II-III, FEV1predicted 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV1predicted 112 ± 16%, age 67 ± 4) conducted identical whole-body resistance training interventions for 13 weeks, consisting of two weekly supervised training sessions. Leg exercises were performed unilaterally, with one leg conducting high-load training (10RM) and the contralateral leg conducting low-load training (30RM). Measurements included muscle strength (nvariables = 7), endurance performance (nvariables = 6), muscle mass (nvariables = 3), muscle quality, muscle biology (m. vastus lateralis; muscle fiber characteristics, RNA content including transcriptome) and health variables (body composition, blood). For core outcome domains, weighted combined factors were calculated from the range of singular assessments. Results COPD displayed well-known pathophysiologies at baseline, including elevated levels of systemic low-grade inflammation ([c-reactive protein]serum), reduced muscle mass and functionality, and muscle biological aberrancies. Despite this, resistance training led to improved lower-limb muscle strength (15 ± 8%), muscle mass (7 ± 5%), muscle quality (8 ± 8%) and lower-limb/whole-body endurance performance (26 ± 12%/8 ± 9%) in COPD, resembling or exceeding responses in Healthy, measured in both relative and numeric change terms. Within the COPD cluster, lower FEV1predicted was associated with larger numeric and relative increases in muscle mass and superior relative improvements in maximal muscle strength. This was accompanied by similar changes in hallmarks of muscle biology such as rRNA-content↑, muscle fiber cross-sectional area↑, type IIX proportions↓, and changes in mRNA transcriptomics. Neither of the core outcome domains were differentially affected by resistance training load. Conclusions COPD showed hitherto largely unrecognized responsiveness to resistance training, rejecting the notion of disease-related impairments and rather advocating such training as a potent measure to relieve pathophysiologies. Trial registration: ClinicalTrials.gov ID: NCT02598830. Registered November 6th 2015, https://clinicaltrials.gov/ct2/show/NCT02598830 |
| first_indexed | 2024-12-19T16:56:30Z |
| format | Article |
| id | doaj.art-d4d8f59bca4b4c1ca6032fbe48e9c959 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-12-19T16:56:30Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-d4d8f59bca4b4c1ca6032fbe48e9c9592022-12-21T20:13:25ZengBMCJournal of Translational Medicine1479-58762021-07-0119112210.1186/s12967-021-02969-1Chronic obstructive pulmonary disease does not impair responses to resistance trainingKnut Sindre Mølmen0Daniel Hammarström1Gunnar Slettaløkken Falch2Morten Grundtvig3Lise Koll4Marita Hanestadhaugen5Yusuf Khan6Rafi Ahmad7Bente Malerbakken8Tore Jørgen Rødølen9Roger Lien10Bent R. Rønnestad11Truls Raastad12Stian Ellefsen13Section for Health and Exercise Physiology, Inland Norway University of Applied SciencesSection for Health and Exercise Physiology, Inland Norway University of Applied SciencesSection for Health and Exercise Physiology, Inland Norway University of Applied SciencesDepartment of Medicine, Innlandet Hospital TrustDepartment of Pathology, Innlandet Hospital TrustDepartment of Pathology, Innlandet Hospital TrustSection for Health and Exercise Physiology, Inland Norway University of Applied SciencesDepartment of Biotechnology, Inland Norway University of Applied SciencesLillehammer Hospital for Rheumatic DiseasesInnlandet Hospital Trust, Granheim Lung HospitalInnlandet Hospital Trust, Granheim Lung HospitalSection for Health and Exercise Physiology, Inland Norway University of Applied SciencesDepartment of Physical Performance, Norwegian School of Sport SciencesSection for Health and Exercise Physiology, Inland Norway University of Applied SciencesAbstract Background Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. Currently, this phenomenon remains largely unstudied. In this study, we aimed to investigate the assumed negative effects of COPD for health- and muscle-related responsiveness to resistance training using a healthy control-based translational approach. Methods Subjects with COPD (n = 20, GOLD II-III, FEV1predicted 57 ± 11%, age 69 ± 5) and healthy controls (Healthy, n = 58, FEV1predicted 112 ± 16%, age 67 ± 4) conducted identical whole-body resistance training interventions for 13 weeks, consisting of two weekly supervised training sessions. Leg exercises were performed unilaterally, with one leg conducting high-load training (10RM) and the contralateral leg conducting low-load training (30RM). Measurements included muscle strength (nvariables = 7), endurance performance (nvariables = 6), muscle mass (nvariables = 3), muscle quality, muscle biology (m. vastus lateralis; muscle fiber characteristics, RNA content including transcriptome) and health variables (body composition, blood). For core outcome domains, weighted combined factors were calculated from the range of singular assessments. Results COPD displayed well-known pathophysiologies at baseline, including elevated levels of systemic low-grade inflammation ([c-reactive protein]serum), reduced muscle mass and functionality, and muscle biological aberrancies. Despite this, resistance training led to improved lower-limb muscle strength (15 ± 8%), muscle mass (7 ± 5%), muscle quality (8 ± 8%) and lower-limb/whole-body endurance performance (26 ± 12%/8 ± 9%) in COPD, resembling or exceeding responses in Healthy, measured in both relative and numeric change terms. Within the COPD cluster, lower FEV1predicted was associated with larger numeric and relative increases in muscle mass and superior relative improvements in maximal muscle strength. This was accompanied by similar changes in hallmarks of muscle biology such as rRNA-content↑, muscle fiber cross-sectional area↑, type IIX proportions↓, and changes in mRNA transcriptomics. Neither of the core outcome domains were differentially affected by resistance training load. Conclusions COPD showed hitherto largely unrecognized responsiveness to resistance training, rejecting the notion of disease-related impairments and rather advocating such training as a potent measure to relieve pathophysiologies. Trial registration: ClinicalTrials.gov ID: NCT02598830. Registered November 6th 2015, https://clinicaltrials.gov/ct2/show/NCT02598830https://doi.org/10.1186/s12967-021-02969-1Anabolic resistanceCOPDPathophysiologySkeletal muscleStrength trainingTraining load |
| spellingShingle | Knut Sindre Mølmen Daniel Hammarström Gunnar Slettaløkken Falch Morten Grundtvig Lise Koll Marita Hanestadhaugen Yusuf Khan Rafi Ahmad Bente Malerbakken Tore Jørgen Rødølen Roger Lien Bent R. Rønnestad Truls Raastad Stian Ellefsen Chronic obstructive pulmonary disease does not impair responses to resistance training Journal of Translational Medicine Anabolic resistance COPD Pathophysiology Skeletal muscle Strength training Training load |
| title | Chronic obstructive pulmonary disease does not impair responses to resistance training |
| title_full | Chronic obstructive pulmonary disease does not impair responses to resistance training |
| title_fullStr | Chronic obstructive pulmonary disease does not impair responses to resistance training |
| title_full_unstemmed | Chronic obstructive pulmonary disease does not impair responses to resistance training |
| title_short | Chronic obstructive pulmonary disease does not impair responses to resistance training |
| title_sort | chronic obstructive pulmonary disease does not impair responses to resistance training |
| topic | Anabolic resistance COPD Pathophysiology Skeletal muscle Strength training Training load |
| url | https://doi.org/10.1186/s12967-021-02969-1 |
| work_keys_str_mv | AT knutsindremølmen chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT danielhammarstrom chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT gunnarslettaløkkenfalch chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT mortengrundtvig chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT lisekoll chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT maritahanestadhaugen chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT yusufkhan chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT rafiahmad chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT bentemalerbakken chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT torejørgenrødølen chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT rogerlien chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT bentrrønnestad chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT trulsraastad chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining AT stianellefsen chronicobstructivepulmonarydiseasedoesnotimpairresponsestoresistancetraining |