Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancy
Aim: Pregnancy is a hypercoagulable state, however it remains unknown the degree to which pregnancy affects standardly drawn coagulation laboratory studies. We intended to establish reference intervals for D-dimer and fibrinogen in the third trimester of pregnancy. Methods: We recruited 1048 healthy...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2021-12-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806213 |
| _version_ | 1811256417066156032 |
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| author | Wenping Sun Yali Zhuang Zhichun Liu Hongmei Liu |
| author_facet | Wenping Sun Yali Zhuang Zhichun Liu Hongmei Liu |
| author_sort | Wenping Sun |
| collection | DOAJ |
| description | Aim: Pregnancy is a hypercoagulable state, however it remains unknown the degree to which pregnancy affects standardly drawn coagulation laboratory studies. We intended to establish reference intervals for D-dimer and fibrinogen in the third trimester of pregnancy. Methods: We recruited 1048 healthy Chinese pregnant women with low-risk pregnancy. Concentrations of D-dimer and fibrinogen in the third trimester were collected. The 2.5th and 97.5th percentile reference intervals of D-dimer and fibrinogen in pregnant women with parity = 1, parity ≥2, maternal age <35 years, maternal age ≥35 years, PPH and non-PPH were established during the third trimester of pregnancy. Results: D-dimer levels were above the conventional cut-off point (0.5 mg/L) in 99.33% of pregnant women. Fibrinogen levels were above the normal upper limit (4 g/L) in 63.93% of pregnant women. The reference interval of D-dimer and fibrinogen in the third trimester of low-risk pregnant women was 0.63–5.05 mg/L and 3.02–5.92 g/L, respectively. Conclusion: The concentration of D-dimer and fibrinogen in the blood during pregnancy differ from the normal population. We recommend that the reference intervals be established for Chinese healthy pregnant women. |
| first_indexed | 2024-04-12T17:40:00Z |
| format | Article |
| id | doaj.art-d4d9887c48364847b1f620891196d2cc |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-04-12T17:40:00Z |
| publishDate | 2021-12-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-d4d9887c48364847b1f620891196d2cc2022-12-22T03:22:50ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632021-12-014861345134910.31083/j.ceog4806213S0390-6663(21)01617-1Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancyWenping Sun0Yali Zhuang1Zhichun Liu2Hongmei Liu3Department of Obstetrics and Gynecology, Maternity and Child Health Hospital Affiliated with Anhui Medical University, Anhui Province Maternity & Child Health Hospital, 230001 Hefei, Anhui, ChinaDepartment of Obstetrics and Gynecology, Maternity and Child Health Hospital Affiliated with Anhui Medical University, Anhui Province Maternity & Child Health Hospital, 230001 Hefei, Anhui, ChinaDepartment of Obstetrics and Gynecology, Maternity and Child Health Hospital Affiliated with Anhui Medical University, Anhui Province Maternity & Child Health Hospital, 230001 Hefei, Anhui, ChinaDepartment of Obstetrics and Gynecology, Maternity and Child Health Hospital Affiliated with Anhui Medical University, Anhui Province Maternity & Child Health Hospital, 230001 Hefei, Anhui, ChinaAim: Pregnancy is a hypercoagulable state, however it remains unknown the degree to which pregnancy affects standardly drawn coagulation laboratory studies. We intended to establish reference intervals for D-dimer and fibrinogen in the third trimester of pregnancy. Methods: We recruited 1048 healthy Chinese pregnant women with low-risk pregnancy. Concentrations of D-dimer and fibrinogen in the third trimester were collected. The 2.5th and 97.5th percentile reference intervals of D-dimer and fibrinogen in pregnant women with parity = 1, parity ≥2, maternal age <35 years, maternal age ≥35 years, PPH and non-PPH were established during the third trimester of pregnancy. Results: D-dimer levels were above the conventional cut-off point (0.5 mg/L) in 99.33% of pregnant women. Fibrinogen levels were above the normal upper limit (4 g/L) in 63.93% of pregnant women. The reference interval of D-dimer and fibrinogen in the third trimester of low-risk pregnant women was 0.63–5.05 mg/L and 3.02–5.92 g/L, respectively. Conclusion: The concentration of D-dimer and fibrinogen in the blood during pregnancy differ from the normal population. We recommend that the reference intervals be established for Chinese healthy pregnant women.https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806213d-dimerfibrinogenreference intervalpostpartum hemorrhage |
| spellingShingle | Wenping Sun Yali Zhuang Zhichun Liu Hongmei Liu Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancy Clinical and Experimental Obstetrics & Gynecology d-dimer fibrinogen reference interval postpartum hemorrhage |
| title | Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancy |
| title_full | Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancy |
| title_fullStr | Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancy |
| title_full_unstemmed | Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancy |
| title_short | Reference intervals for D-dimer and fibrinogen in the Chinese population during the third trimester of pregnancy |
| title_sort | reference intervals for d dimer and fibrinogen in the chinese population during the third trimester of pregnancy |
| topic | d-dimer fibrinogen reference interval postpartum hemorrhage |
| url | https://www.imrpress.com/journal/CEOG/48/6/10.31083/j.ceog4806213 |
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