Local Glucocorticoids in Treatment of Children with Dermatitis
Local glucocorticoids (GCs) are the gold standard of anti-inflammatory topical therapy. The description of the main pharmaceutics properties and classification of local GCs, as well as its indications and contradictions are presented in the article. This article also provides fundamentals for applic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2020-01-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/2237 |
| _version_ | 1826561761910718464 |
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| author | Yliya G. Levina Leyla S. Namazova-Baranova Kamilla E. Efendiyeva Anna A. Alexeyeva Elena A. Vishnyova Vera G. Kalugina Polina S. Arimova |
| author_facet | Yliya G. Levina Leyla S. Namazova-Baranova Kamilla E. Efendiyeva Anna A. Alexeyeva Elena A. Vishnyova Vera G. Kalugina Polina S. Arimova |
| author_sort | Yliya G. Levina |
| collection | DOAJ |
| description | Local glucocorticoids (GCs) are the gold standard of anti-inflammatory topical therapy. The description of the main pharmaceutics properties and classification of local GCs, as well as its indications and contradictions are presented in the article. This article also provides fundamentals for application of local GCs which should be implemented for effective and safe use of these drugs in children. The problems of steroid-phobia (one of the reasons of the wrong and untimely administration of local GCs) are discussed. Advantages of 0.1% methylprednisolone aceponate (new generation GCs) use are discussed. This medication has optimal efficiency/safety ratio and unique bioactivation pathway that enables its effective administration in management of various dermatitis in children from 4 months of age. Results of different comparative and double blind placebo-controlled clinical trials of 0.1% methylprednisolone aceponate administration are discussed in this article. High efficiency and safety of this medication are noted. The use of modern local GCs at the first signs of skin inflammatory changes allows to relieve aggravation quickly and achieve remission of the disease. |
| first_indexed | 2024-03-12T03:41:04Z |
| format | Article |
| id | doaj.art-d4da56b609d64e6284621f3abe1cefe4 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2025-03-14T09:37:19Z |
| publishDate | 2020-01-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-d4da56b609d64e6284621f3abe1cefe42025-03-02T11:34:22Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352020-01-0118538038510.15690/vsp.v18i5.20631841Local Glucocorticoids in Treatment of Children with DermatitisYliya G. Levina0Leyla S. Namazova-Baranova1Kamilla E. Efendiyeva2Anna A. Alexeyeva3Elena A. Vishnyova4Vera G. Kalugina5Polina S. Arimova6Central Clinical Hospital of the Russian Academy of SciencesCentral Clinical Hospital of the Russian Academy of Sciences; Pirogov Russian National Research Medical UniversityCentral Clinical Hospital of the Russian Academy of Sciences; Pirogov Russian National Research Medical UniversityCentral Clinical Hospital of the Russian Academy of SciencesCentral Clinical Hospital of the Russian Academy of Sciences; Pirogov Russian National Research Medical UniversityCentral Clinical Hospital of the Russian Academy of SciencesCentral Clinical Hospital of the Russian Academy of SciencesLocal glucocorticoids (GCs) are the gold standard of anti-inflammatory topical therapy. The description of the main pharmaceutics properties and classification of local GCs, as well as its indications and contradictions are presented in the article. This article also provides fundamentals for application of local GCs which should be implemented for effective and safe use of these drugs in children. The problems of steroid-phobia (one of the reasons of the wrong and untimely administration of local GCs) are discussed. Advantages of 0.1% methylprednisolone aceponate (new generation GCs) use are discussed. This medication has optimal efficiency/safety ratio and unique bioactivation pathway that enables its effective administration in management of various dermatitis in children from 4 months of age. Results of different comparative and double blind placebo-controlled clinical trials of 0.1% methylprednisolone aceponate administration are discussed in this article. High efficiency and safety of this medication are noted. The use of modern local GCs at the first signs of skin inflammatory changes allows to relieve aggravation quickly and achieve remission of the disease.https://vsp.spr-journal.ru/jour/article/view/2237local glucocorticoidschildrendermatitisatopic dermatitismethylprednisolone aceponate |
| spellingShingle | Yliya G. Levina Leyla S. Namazova-Baranova Kamilla E. Efendiyeva Anna A. Alexeyeva Elena A. Vishnyova Vera G. Kalugina Polina S. Arimova Local Glucocorticoids in Treatment of Children with Dermatitis Вопросы современной педиатрии local glucocorticoids children dermatitis atopic dermatitis methylprednisolone aceponate |
| title | Local Glucocorticoids in Treatment of Children with Dermatitis |
| title_full | Local Glucocorticoids in Treatment of Children with Dermatitis |
| title_fullStr | Local Glucocorticoids in Treatment of Children with Dermatitis |
| title_full_unstemmed | Local Glucocorticoids in Treatment of Children with Dermatitis |
| title_short | Local Glucocorticoids in Treatment of Children with Dermatitis |
| title_sort | local glucocorticoids in treatment of children with dermatitis |
| topic | local glucocorticoids children dermatitis atopic dermatitis methylprednisolone aceponate |
| url | https://vsp.spr-journal.ru/jour/article/view/2237 |
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