Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder
We propose that the mitochondrion, an essential cellular organelle, mediates the long-term prenatal environmental effects of disease in autism spectrum disorder (ASD). Many prenatal environmental factors which increase the risk of developing ASD influence mitochondria physiology, including toxicant...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/3/218 |
| _version_ | 1797540871567048704 |
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| author | Richard E. Frye Janet Cakir Shannon Rose Raymond F. Palmer Christine Austin Paul Curtin Manish Arora |
| author_facet | Richard E. Frye Janet Cakir Shannon Rose Raymond F. Palmer Christine Austin Paul Curtin Manish Arora |
| author_sort | Richard E. Frye |
| collection | DOAJ |
| description | We propose that the mitochondrion, an essential cellular organelle, mediates the long-term prenatal environmental effects of disease in autism spectrum disorder (ASD). Many prenatal environmental factors which increase the risk of developing ASD influence mitochondria physiology, including toxicant exposures, immune activation, and nutritional factors. Unique types of mitochondrial dysfunction have been associated with ASD and recent studies have linked prenatal environmental exposures to long-term changes in mitochondrial physiology in children with ASD. A better understanding of the role of the mitochondria in the etiology of ASD can lead to targeted therapeutics and strategies to potentially prevent the development of ASD. |
| first_indexed | 2024-03-10T13:07:12Z |
| format | Article |
| id | doaj.art-d4da6ec25b6a409ebbcfec326305bd0e |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T13:07:12Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-d4da6ec25b6a409ebbcfec326305bd0e2023-11-21T11:03:22ZengMDPI AGJournal of Personalized Medicine2075-44262021-03-0111321810.3390/jpm11030218Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum DisorderRichard E. Frye0Janet Cakir1Shannon Rose2Raymond F. Palmer3Christine Austin4Paul Curtin5Manish Arora6Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, AZ 85016, USADepartment of Applied Ecology, North Carolina State University, Raleigh, NC 27695, USADepartment of Pediatrics, Arkansas Children’s Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USADepartment of Family and Community Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USADepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USAWe propose that the mitochondrion, an essential cellular organelle, mediates the long-term prenatal environmental effects of disease in autism spectrum disorder (ASD). Many prenatal environmental factors which increase the risk of developing ASD influence mitochondria physiology, including toxicant exposures, immune activation, and nutritional factors. Unique types of mitochondrial dysfunction have been associated with ASD and recent studies have linked prenatal environmental exposures to long-term changes in mitochondrial physiology in children with ASD. A better understanding of the role of the mitochondria in the etiology of ASD can lead to targeted therapeutics and strategies to potentially prevent the development of ASD.https://www.mdpi.com/2075-4426/11/3/218autism spectrum disordermitochondriaoxidative stressprenatal environmentimmune dysfunction |
| spellingShingle | Richard E. Frye Janet Cakir Shannon Rose Raymond F. Palmer Christine Austin Paul Curtin Manish Arora Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder Journal of Personalized Medicine autism spectrum disorder mitochondria oxidative stress prenatal environment immune dysfunction |
| title | Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder |
| title_full | Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder |
| title_fullStr | Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder |
| title_full_unstemmed | Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder |
| title_short | Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder |
| title_sort | mitochondria may mediate prenatal environmental influences in autism spectrum disorder |
| topic | autism spectrum disorder mitochondria oxidative stress prenatal environment immune dysfunction |
| url | https://www.mdpi.com/2075-4426/11/3/218 |
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