Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons

Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons

Background: Sevoflurane, a commonly administered inhaled anesthetic, is found to induce synaptic and mitochondrial damage in neonatal mice. Mitochondrial membrane potential (MMP) changes, mediated by Cyclophilin D (CypD), are implicated in mitochondrial function. Melatonin, known for its significant...

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Bibliographic Details
Main Authors: Xuezhu Zou, Xiaoyuan Zhang, Tingting Qiang, Xianwen Hu, Li Zhang
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Brain Research Bulletin
Subjects:
Sevoflurane-induced cognitive deficits
Melatonin
Synaptic development
Parvalbumin neuron
Cyclophilin D
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923023002344

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