Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma
Esophageal cancer (EC) remains a public health concern with a high mortality and disease burden worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant histological subtype of EC that has unique etiology, molecular profiles, and clinicopathological features. Although systemic chemother...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2023-01-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/17588359221138377 |
| _version_ | 1797953554162384896 |
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| author | Akira Ooki Hiroki Osumi Keisho Chin Masayuki Watanabe Kensei Yamaguchi |
| author_facet | Akira Ooki Hiroki Osumi Keisho Chin Masayuki Watanabe Kensei Yamaguchi |
| author_sort | Akira Ooki |
| collection | DOAJ |
| description | Esophageal cancer (EC) remains a public health concern with a high mortality and disease burden worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant histological subtype of EC that has unique etiology, molecular profiles, and clinicopathological features. Although systemic chemotherapy, including cytotoxic agents and immune checkpoint inhibitors, is the main therapeutic option for recurrent or metastatic ESCC patients, the clinical benefits are limited with poor prognosis. Personalized molecular-targeted therapies have been hampered due to the lack of robust treatment efficacy in clinical trials. Therefore, there is an urgent need to develop effective therapeutic strategies. In this review, we summarize the molecular profiles of ESCC based on the findings of pivotal comprehensive molecular analyses, highlighting potent therapeutic targets for establishing future precision medicine for ESCC patients, with the most recent results of clinical trials. |
| first_indexed | 2024-04-10T23:05:01Z |
| format | Article |
| id | doaj.art-d4de0e4eddee466e86091481d9000fc4 |
| institution | Directory Open Access Journal |
| issn | 1758-8359 |
| language | English |
| last_indexed | 2024-04-10T23:05:01Z |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj.art-d4de0e4eddee466e86091481d9000fc42023-01-13T14:03:28ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592023-01-011510.1177/17588359221138377Potent molecular-targeted therapies for advanced esophageal squamous cell carcinomaAkira OokiHiroki OsumiKeisho ChinMasayuki WatanabeKensei YamaguchiEsophageal cancer (EC) remains a public health concern with a high mortality and disease burden worldwide. Esophageal squamous cell carcinoma (ESCC) is a predominant histological subtype of EC that has unique etiology, molecular profiles, and clinicopathological features. Although systemic chemotherapy, including cytotoxic agents and immune checkpoint inhibitors, is the main therapeutic option for recurrent or metastatic ESCC patients, the clinical benefits are limited with poor prognosis. Personalized molecular-targeted therapies have been hampered due to the lack of robust treatment efficacy in clinical trials. Therefore, there is an urgent need to develop effective therapeutic strategies. In this review, we summarize the molecular profiles of ESCC based on the findings of pivotal comprehensive molecular analyses, highlighting potent therapeutic targets for establishing future precision medicine for ESCC patients, with the most recent results of clinical trials.https://doi.org/10.1177/17588359221138377 |
| spellingShingle | Akira Ooki Hiroki Osumi Keisho Chin Masayuki Watanabe Kensei Yamaguchi Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma Therapeutic Advances in Medical Oncology |
| title | Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma |
| title_full | Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma |
| title_fullStr | Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma |
| title_full_unstemmed | Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma |
| title_short | Potent molecular-targeted therapies for advanced esophageal squamous cell carcinoma |
| title_sort | potent molecular targeted therapies for advanced esophageal squamous cell carcinoma |
| url | https://doi.org/10.1177/17588359221138377 |
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