KLF4 K409Q –mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment

KLF4 K409Q –mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment

Abstract Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however...

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Bibliographic Details
Main Authors: Niklas von Spreckelsen, Natalie Waldt, Rebecca Poetschke, Christoph Kesseler, Hildegard Dohmen, Hui-Ke Jiao, Attila Nemeth, Stefan Schob, Cordula Scherlach, Ibrahim Erol Sandalcioglu, Martina Deckert, Frank Angenstein, Boris Krischek, Pantelis Stavrinou, Marco Timmer, Marc Remke, Elmar Kirches, Roland Goldbrunner, E. Antonio Chiocca, Stefan Huettelmaier, Till Acker, Christian Mawrin
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Acta Neuropathologica Communications
Subjects:
Meningioma
Mutation
K409Q
Hypoxia
HIF
Edema
Online Access:http://link.springer.com/article/10.1186/s40478-020-00912-x

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