The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer
Triple negative breast (TNBC) cancer constitutes a heterogeneous group of disease with histologic and molecular differences. Complete pathologic response to neoadjuvant chemotherapy (NACT) in TNBC is associated with improved outcomes. Efforts have been made in identifying drug combinations that will...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-03-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/324 |
| _version_ | 1797966218430251008 |
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| author | Aurelio Bartolome Castrellon Ihor Pidhorecky Vicente Valero Luis Estuardo Raez |
| author_facet | Aurelio Bartolome Castrellon Ihor Pidhorecky Vicente Valero Luis Estuardo Raez |
| author_sort | Aurelio Bartolome Castrellon |
| collection | DOAJ |
| description | Triple negative breast (TNBC) cancer constitutes a heterogeneous group of disease with histologic and molecular differences. Complete pathologic response to neoadjuvant chemotherapy (NACT) in TNBC is associated with improved outcomes. Efforts have been made in identifying drug combinations that will increase the response rate to preoperative chemotherapy. In this review we present recent studies that have incorporated carboplatin (Cb) in the NACT of TNBC. We discuss the homologous recombination deficiency score and the somatic or germline mutation for BRCA as potential biomarkers for future selection of patients that could benefit from the addition of Cb to NACT. |
| first_indexed | 2024-04-11T02:11:08Z |
| format | Article |
| id | doaj.art-d4e077f9940c48a8880784b7e7c30b23 |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T02:11:08Z |
| publishDate | 2017-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-d4e077f9940c48a8880784b7e7c30b232023-01-03T02:05:19ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652017-03-0111110.4081/oncol.2017.324225The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancerAurelio Bartolome Castrellon0Ihor Pidhorecky1Vicente Valero2Luis Estuardo Raez3Breast Cancer Research, Memorial Cancer Institute, Memorial Healthcare System, Hollywood, FLSurgical Oncology Services & Pancreaticobiliary Center, Memorial Cancer Institute, Memorial Healthcare System, Hollywood, FLDepartment of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TXHematology/Oncology and Medical Director of Memorial Cancer Institute, Memorial Healthcare System, Hollywood, FLTriple negative breast (TNBC) cancer constitutes a heterogeneous group of disease with histologic and molecular differences. Complete pathologic response to neoadjuvant chemotherapy (NACT) in TNBC is associated with improved outcomes. Efforts have been made in identifying drug combinations that will increase the response rate to preoperative chemotherapy. In this review we present recent studies that have incorporated carboplatin (Cb) in the NACT of TNBC. We discuss the homologous recombination deficiency score and the somatic or germline mutation for BRCA as potential biomarkers for future selection of patients that could benefit from the addition of Cb to NACT.http://www.oncologyreviews.org/index.php/or/article/view/324Breast cancerneoadjuvant chemotherapyplatinum agents. |
| spellingShingle | Aurelio Bartolome Castrellon Ihor Pidhorecky Vicente Valero Luis Estuardo Raez The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer Oncology Reviews Breast cancer neoadjuvant chemotherapy platinum agents. |
| title | The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer |
| title_full | The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer |
| title_fullStr | The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer |
| title_full_unstemmed | The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer |
| title_short | The role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer |
| title_sort | role of carboplatin in the neoadjuvant chemotherapy treatment of triple negative breast cancer |
| topic | Breast cancer neoadjuvant chemotherapy platinum agents. |
| url | http://www.oncologyreviews.org/index.php/or/article/view/324 |
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