Insulin, aging and the brain: mechanisms and implications.
There is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. Howe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00013/full |
| _version_ | 1811217468500213760 |
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| author | Abimbola A. eAkintola Diana evan Heemst, |
| author_facet | Abimbola A. eAkintola Diana evan Heemst, |
| author_sort | Abimbola A. eAkintola |
| collection | DOAJ |
| description | There is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. However, the relevance of these to aging and longevity remains to be elucidated. Here, we review advances in our understanding of the physiological role of insulin in the brain, how insulin gets into the brain, and its relevance to aging and longevity. Furthermore, we examine possible future therapeutic applications and implications of insulin in the context of available models of delayed and accelerated aging. |
| first_indexed | 2024-04-12T06:55:17Z |
| format | Article |
| id | doaj.art-d4e160df17ec45ada48de8bd2956b482 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T06:55:17Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d4e160df17ec45ada48de8bd2956b4822022-12-22T03:43:11ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922015-02-01610.3389/fendo.2015.00013126606Insulin, aging and the brain: mechanisms and implications.Abimbola A. eAkintola0Diana evan Heemst,1Leiden university medical centerLeiden university medical centerThere is now an impressive body of literature implicating insulin and insulin signaling in successful aging and longevity. New information from in vivo and in vitro studies concerning insulin and insulin receptors has extended our understanding of the physiological role of insulin in the brain. However, the relevance of these to aging and longevity remains to be elucidated. Here, we review advances in our understanding of the physiological role of insulin in the brain, how insulin gets into the brain, and its relevance to aging and longevity. Furthermore, we examine possible future therapeutic applications and implications of insulin in the context of available models of delayed and accelerated aging.http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00013/fullBrainInflammationInsulininsulin receptorsaccelerated aginglongevity. |
| spellingShingle | Abimbola A. eAkintola Diana evan Heemst, Insulin, aging and the brain: mechanisms and implications. Frontiers in Endocrinology Brain Inflammation Insulin insulin receptors accelerated aging longevity. |
| title | Insulin, aging and the brain: mechanisms and implications. |
| title_full | Insulin, aging and the brain: mechanisms and implications. |
| title_fullStr | Insulin, aging and the brain: mechanisms and implications. |
| title_full_unstemmed | Insulin, aging and the brain: mechanisms and implications. |
| title_short | Insulin, aging and the brain: mechanisms and implications. |
| title_sort | insulin aging and the brain mechanisms and implications |
| topic | Brain Inflammation Insulin insulin receptors accelerated aging longevity. |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00013/full |
| work_keys_str_mv | AT abimbolaaeakintola insulinagingandthebrainmechanismsandimplications AT dianaevanheemst insulinagingandthebrainmechanismsandimplications |