Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j mice
Background: Hypercholesterolemia is a disease associated with numerous health problems. Growing evidence indicates that hypercholesterolemia, hyperlipidemia is closely linked to chronic inflammation, which can lead to cardiovascular disease, fatty liver disease, and type 2 diabetes. Objective: The p...
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| Format: | Article |
| Language: | English |
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Swedish Nutrition Foundation
2019-12-01
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| Series: | Food & Nutrition Research |
| Subjects: | |
| Online Access: | https://foodandnutritionresearch.net/index.php/fnr/article/view/3618/9998 |
| _version_ | 1819278136476434432 |
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| author | Fenfen Wei Yinlu Liu Cuicui Bi Bo Zhang |
| author_facet | Fenfen Wei Yinlu Liu Cuicui Bi Bo Zhang |
| author_sort | Fenfen Wei |
| collection | DOAJ |
| description | Background: Hypercholesterolemia is a disease associated with numerous health problems. Growing evidence indicates that hypercholesterolemia, hyperlipidemia is closely linked to chronic inflammation, which can lead to cardiovascular disease, fatty liver disease, and type 2 diabetes. Objective: The purpose of this study was to investigate the protective effect of Nostoc sphaeroids Kütz (NO) on diet-induced hyperlipidemia in mice. Design: At first, experimental animals received a high-fat diet (HFD) for 4 weeks, and then received a HFD supplemented with 2.5% or 7.5% NO for 6 weeks. In the current study, results show that treatment with NO decreases weight gain and liver index induced by HFD. In addition, the serum levels of TC, TG and LDL are significantly decreased in NO treatment groups. Results: From the results of Oil Red staining and Hematoxylin and eosin staining (HE), treatment with NO significantly reduces liver lipid accumulation and protect liver structure. Further analysis reveals that NO has positive effects on liver lipid metabolism and inflammation, as showed by the lower protein expressions of FAS and SREBP-1, the lower concentrations of TNF-α, IL-1β, IL-6, and the lower gene expressions of TNF-α, IL-1β, IL-6 and NF-kB. Conclusions: Our results indicate that NO may significantly ameliorate diet-induced hyperlipidemia, which is possibly associated with improving liver lipid metabolism and reducing chronic inflammation. |
| first_indexed | 2024-12-24T00:07:13Z |
| format | Article |
| id | doaj.art-d4e35fd4040d43458c4c691ae60209bc |
| institution | Directory Open Access Journal |
| issn | 1654-661X |
| language | English |
| last_indexed | 2024-12-24T00:07:13Z |
| publishDate | 2019-12-01 |
| publisher | Swedish Nutrition Foundation |
| record_format | Article |
| series | Food & Nutrition Research |
| spelling | doaj.art-d4e35fd4040d43458c4c691ae60209bc2022-12-21T17:24:59ZengSwedish Nutrition FoundationFood & Nutrition Research1654-661X2019-12-0163011010.29219/fnr.v63.36183618Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j miceFenfen Wei0Yinlu Liu1Cuicui Bi2Bo Zhang3Research Institute for Science and Technology of Functional Foods; Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, ChinaResearch Institute for Science and Technology of Functional Foods; Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, ChinaResearch Institute for Science and Technology of Functional Foods; Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, ChinaResearch Institute for Science and Technology of Functional Foods; Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing, ChinaBackground: Hypercholesterolemia is a disease associated with numerous health problems. Growing evidence indicates that hypercholesterolemia, hyperlipidemia is closely linked to chronic inflammation, which can lead to cardiovascular disease, fatty liver disease, and type 2 diabetes. Objective: The purpose of this study was to investigate the protective effect of Nostoc sphaeroids Kütz (NO) on diet-induced hyperlipidemia in mice. Design: At first, experimental animals received a high-fat diet (HFD) for 4 weeks, and then received a HFD supplemented with 2.5% or 7.5% NO for 6 weeks. In the current study, results show that treatment with NO decreases weight gain and liver index induced by HFD. In addition, the serum levels of TC, TG and LDL are significantly decreased in NO treatment groups. Results: From the results of Oil Red staining and Hematoxylin and eosin staining (HE), treatment with NO significantly reduces liver lipid accumulation and protect liver structure. Further analysis reveals that NO has positive effects on liver lipid metabolism and inflammation, as showed by the lower protein expressions of FAS and SREBP-1, the lower concentrations of TNF-α, IL-1β, IL-6, and the lower gene expressions of TNF-α, IL-1β, IL-6 and NF-kB. Conclusions: Our results indicate that NO may significantly ameliorate diet-induced hyperlipidemia, which is possibly associated with improving liver lipid metabolism and reducing chronic inflammation.https://foodandnutritionresearch.net/index.php/fnr/article/view/3618/9998nostoc sphaeroids kützhigh-fat dietlipidmetabolism disordersmice |
| spellingShingle | Fenfen Wei Yinlu Liu Cuicui Bi Bo Zhang Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j mice Food & Nutrition Research nostoc sphaeroids kütz high-fat diet lipid metabolism disorders mice |
| title | Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j mice |
| title_full | Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j mice |
| title_fullStr | Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j mice |
| title_full_unstemmed | Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j mice |
| title_short | Nostoc sphaeroids Kütz powder ameliorates diet-induced hyperlipidemia in C57BL/6j mice |
| title_sort | nostoc sphaeroids kutz powder ameliorates diet induced hyperlipidemia in c57bl 6j mice |
| topic | nostoc sphaeroids kütz high-fat diet lipid metabolism disorders mice |
| url | https://foodandnutritionresearch.net/index.php/fnr/article/view/3618/9998 |
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