Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review
Introduction Pain management in patients with chronic pain and comorbid depression is challenging and understudied. There is interest in intermittent theta-burst stimulation (iTBS), a new modality of repetitive transcranial magnetic stimulation (rTMS). This retrospective review describes changes in...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Canadian Journal of Pain |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/24740527.2023.2300026 |
| _version_ | 1826930928162701312 |
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| author | Sawmmiya Kirupaharan Roumen Milev Joanne Bressee Sonya Kelso Scott Duggan Felicia Iftene Tim V. Salomons Wilma Hopman Ian Gilron |
| author_facet | Sawmmiya Kirupaharan Roumen Milev Joanne Bressee Sonya Kelso Scott Duggan Felicia Iftene Tim V. Salomons Wilma Hopman Ian Gilron |
| author_sort | Sawmmiya Kirupaharan |
| collection | DOAJ |
| description | Introduction Pain management in patients with chronic pain and comorbid depression is challenging and understudied. There is interest in intermittent theta-burst stimulation (iTBS), a new modality of repetitive transcranial magnetic stimulation (rTMS). This retrospective review describes changes in pain, anxiety and depression throughout iTBS treatment at the dorsolateral prefrontal cortex (DLPFC).Methods A retrospective chart review was conducted of patients who underwent their first acute series of iTBS treatments at the DLPFC for depression at a single institution between 2020 and 2023. Data on depression, anxiety, and pain were collected throughout iTBS treatment using the Beck Depression Inventory–II (BDI-II; higher scores indicate worse depression) and visual analogue scale (VAS; 0–100, higher scores indicate worse pain, anxiety, and depression). Nonparametric tests were used for all analyses.Results Of 104 patients, 52 reported moderate pain at baseline (50.0%). Median BDI-II scores decreased from 38.0 (interquartile range [IQR] = 29.0–44.0) to 24.0 (IQR = 9.0–36.0) from pre- to posttreatment (P < 0.001). Of the 32 patients with both pre- and posttreatment pain scores, there was a significant decrease from 40.0 (IQR = 5.5–71.8) to 15.0 (IQR = 3.5–53.8; P = 0.037). In patients with at least moderate pain at baseline, pain scores decreased from 71.0 (IQR = 55.0–80.0) to 20.0 (IQR = 11.0–71.0; P = 0.004). Ten of 32 patients with available pre- and posttreatment scores reported ≥30% reduction in pain scores (31.2%).Conclusion These preliminary results, suggesting decreases in pain following iTBS treatment, provide a rationale for future rigorous investigations to evaluate this intervention for depression and comorbid chronic pain. |
| first_indexed | 2024-04-25T00:18:12Z |
| format | Article |
| id | doaj.art-d4e92dd040324676a25614906f9d6bd8 |
| institution | Directory Open Access Journal |
| issn | 2474-0527 |
| language | English |
| last_indexed | 2025-02-17T16:36:48Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Canadian Journal of Pain |
| spelling | doaj.art-d4e92dd040324676a25614906f9d6bd82024-12-16T20:54:59ZengTaylor & Francis GroupCanadian Journal of Pain2474-05272024-12-018110.1080/24740527.2023.2300026Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart reviewSawmmiya Kirupaharan0Roumen Milev1Joanne Bressee2Sonya Kelso3Scott Duggan4Felicia Iftene5Tim V. Salomons6Wilma Hopman7Ian Gilron8Faculty of Health Sciences, Queen’s University, Kingston, Ontario, CanadaDepartment of Psychiatry, Queen’s University, Kingston, Ontario, CanadaProvidence Care Hospital, Kingston, Ontario, CanadaProvidence Care Hospital, Kingston, Ontario, CanadaDepartment of Anesthesiology and Perioperative Medicine, Queen’s University, Kingston, Ontario, CanadaDepartment of Psychiatry, Queen’s University, Kingston, Ontario, CanadaDepartment of Psychology, Queen’s University, Kingston, Ontario, CanadaDepartment of Public Health Sciences, Queen’s University, Kingston, Ontario, CanadaProvidence Care Hospital, Kingston, Ontario, CanadaIntroduction Pain management in patients with chronic pain and comorbid depression is challenging and understudied. There is interest in intermittent theta-burst stimulation (iTBS), a new modality of repetitive transcranial magnetic stimulation (rTMS). This retrospective review describes changes in pain, anxiety and depression throughout iTBS treatment at the dorsolateral prefrontal cortex (DLPFC).Methods A retrospective chart review was conducted of patients who underwent their first acute series of iTBS treatments at the DLPFC for depression at a single institution between 2020 and 2023. Data on depression, anxiety, and pain were collected throughout iTBS treatment using the Beck Depression Inventory–II (BDI-II; higher scores indicate worse depression) and visual analogue scale (VAS; 0–100, higher scores indicate worse pain, anxiety, and depression). Nonparametric tests were used for all analyses.Results Of 104 patients, 52 reported moderate pain at baseline (50.0%). Median BDI-II scores decreased from 38.0 (interquartile range [IQR] = 29.0–44.0) to 24.0 (IQR = 9.0–36.0) from pre- to posttreatment (P < 0.001). Of the 32 patients with both pre- and posttreatment pain scores, there was a significant decrease from 40.0 (IQR = 5.5–71.8) to 15.0 (IQR = 3.5–53.8; P = 0.037). In patients with at least moderate pain at baseline, pain scores decreased from 71.0 (IQR = 55.0–80.0) to 20.0 (IQR = 11.0–71.0; P = 0.004). Ten of 32 patients with available pre- and posttreatment scores reported ≥30% reduction in pain scores (31.2%).Conclusion These preliminary results, suggesting decreases in pain following iTBS treatment, provide a rationale for future rigorous investigations to evaluate this intervention for depression and comorbid chronic pain.https://www.tandfonline.com/doi/10.1080/24740527.2023.2300026chronic paindepressiontranscranial magnetic stimulationneuromodulation |
| spellingShingle | Sawmmiya Kirupaharan Roumen Milev Joanne Bressee Sonya Kelso Scott Duggan Felicia Iftene Tim V. Salomons Wilma Hopman Ian Gilron Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review Canadian Journal of Pain chronic pain depression transcranial magnetic stimulation neuromodulation |
| title | Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review |
| title_full | Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review |
| title_fullStr | Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review |
| title_full_unstemmed | Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review |
| title_short | Changes in pain following bilateral intermittent theta-burst, transcranial magnetic stimulation for depression: A retrospective chart review |
| title_sort | changes in pain following bilateral intermittent theta burst transcranial magnetic stimulation for depression a retrospective chart review |
| topic | chronic pain depression transcranial magnetic stimulation neuromodulation |
| url | https://www.tandfonline.com/doi/10.1080/24740527.2023.2300026 |
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