Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population.
To investigate whether differences exist in lens position and other lens parameters among major ethnic groups with cataractous eyes, which may help explain racial differences in angle closure risk.This retrospective, cross-sectional study included 807 adult patients who had cataract surgery between...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5487046?pdf=render |
| _version_ | 1818264566344187904 |
|---|---|
| author | Dajiang Wang Behzad Amoozgar Travis Porco Zhen Wang Shan C Lin |
| author_facet | Dajiang Wang Behzad Amoozgar Travis Porco Zhen Wang Shan C Lin |
| author_sort | Dajiang Wang |
| collection | DOAJ |
| description | To investigate whether differences exist in lens position and other lens parameters among major ethnic groups with cataractous eyes, which may help explain racial differences in angle closure risk.This retrospective, cross-sectional study included 807 adult patients who had cataract surgery between years 2014 and 2016 at the University of California, San Francisco (UCSF). Adult patients of white, Asian, Hispanic and African-American ethnicity were included. Lens position (LP), defined as anterior chamber depth (ACD) + 1/2 lens thickness (LT), was assessed using measurements from optical biometry. Other assessed biometric parameters included axial length (AL), relative lens position (RLP) (defined as LP/AL), and anterior chamber depth (ACD).A total of 807 patients and 1361 eyes were included in this study from a database of patients having cataract surgery. Mean age was 69.2 years (age range from 18 to 101 years old), and 60.3% of patients were women. The mean LP measurements were 5.54±0.32 mm for white, 5.38±0.32 mm for Asian, 5.32±0.30 mm for Hispanic, and 5.40±0.28 mm for African-American participants. After adjusting for age, sex, and AL, significant differences were found when comparing LP in paired comparisons among White cohort with Asians (P<0.001), Hispanics (P<0.001) and African-Americans (P = 0.003). Additionally, when comparing RLP, similar significant results were found when comparing Whites with Asians (P<0.001), Hispanics (P<0.001) and African-Americans (P = 0.002). Lastly, pair-wise comparison of LT between ethnic groups showed significant differences while comparing Asians with Whites (P = 0.001) and Asians with African-Americans (P<0.001).The results of this study suggest that the LP of Hispanic, Asian, and African-American patients are significantly smaller than that of White patients, and among all ethnic groups, Hispanics and after Asians have the smallest LP (P<0.001) and RLP (P<0.001). These findings may have implications for the relative risk of angle closure and the potential IOP response after cataract surgery among different ethnic groups. |
| first_indexed | 2024-12-12T19:36:57Z |
| format | Article |
| id | doaj.art-d4e933f65e8f4a2db69e015bc1972578 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T19:36:57Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d4e933f65e8f4a2db69e015bc19725782022-12-22T00:14:18ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01126e017983610.1371/journal.pone.0179836Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population.Dajiang WangBehzad AmoozgarTravis PorcoZhen WangShan C LinTo investigate whether differences exist in lens position and other lens parameters among major ethnic groups with cataractous eyes, which may help explain racial differences in angle closure risk.This retrospective, cross-sectional study included 807 adult patients who had cataract surgery between years 2014 and 2016 at the University of California, San Francisco (UCSF). Adult patients of white, Asian, Hispanic and African-American ethnicity were included. Lens position (LP), defined as anterior chamber depth (ACD) + 1/2 lens thickness (LT), was assessed using measurements from optical biometry. Other assessed biometric parameters included axial length (AL), relative lens position (RLP) (defined as LP/AL), and anterior chamber depth (ACD).A total of 807 patients and 1361 eyes were included in this study from a database of patients having cataract surgery. Mean age was 69.2 years (age range from 18 to 101 years old), and 60.3% of patients were women. The mean LP measurements were 5.54±0.32 mm for white, 5.38±0.32 mm for Asian, 5.32±0.30 mm for Hispanic, and 5.40±0.28 mm for African-American participants. After adjusting for age, sex, and AL, significant differences were found when comparing LP in paired comparisons among White cohort with Asians (P<0.001), Hispanics (P<0.001) and African-Americans (P = 0.003). Additionally, when comparing RLP, similar significant results were found when comparing Whites with Asians (P<0.001), Hispanics (P<0.001) and African-Americans (P = 0.002). Lastly, pair-wise comparison of LT between ethnic groups showed significant differences while comparing Asians with Whites (P = 0.001) and Asians with African-Americans (P<0.001).The results of this study suggest that the LP of Hispanic, Asian, and African-American patients are significantly smaller than that of White patients, and among all ethnic groups, Hispanics and after Asians have the smallest LP (P<0.001) and RLP (P<0.001). These findings may have implications for the relative risk of angle closure and the potential IOP response after cataract surgery among different ethnic groups.http://europepmc.org/articles/PMC5487046?pdf=render |
| spellingShingle | Dajiang Wang Behzad Amoozgar Travis Porco Zhen Wang Shan C Lin Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population. PLoS ONE |
| title | Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population. |
| title_full | Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population. |
| title_fullStr | Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population. |
| title_full_unstemmed | Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population. |
| title_short | Ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population. |
| title_sort | ethnic differences in lens parameters measured by ocular biometry in a cataract surgery population |
| url | http://europepmc.org/articles/PMC5487046?pdf=render |
| work_keys_str_mv | AT dajiangwang ethnicdifferencesinlensparametersmeasuredbyocularbiometryinacataractsurgerypopulation AT behzadamoozgar ethnicdifferencesinlensparametersmeasuredbyocularbiometryinacataractsurgerypopulation AT travisporco ethnicdifferencesinlensparametersmeasuredbyocularbiometryinacataractsurgerypopulation AT zhenwang ethnicdifferencesinlensparametersmeasuredbyocularbiometryinacataractsurgerypopulation AT shanclin ethnicdifferencesinlensparametersmeasuredbyocularbiometryinacataractsurgerypopulation |