The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations
Spondyloarthritis (SpA) contemplates the inflammatory involvement of the musculoskeletal system, gut, skin, and eyes, delineating heterogeneous diseases with a common pathogenetic background. In the framework of innate and adaptive immune disruption in SpA, neutrophils are arising, across different...
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/4108 |
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| author | Lavinia Agra Coletto Chiara Rizzo Giuliana Guggino Roberto Caporali Stefano Alivernini Maria Antonietta D’Agostino |
| author_facet | Lavinia Agra Coletto Chiara Rizzo Giuliana Guggino Roberto Caporali Stefano Alivernini Maria Antonietta D’Agostino |
| author_sort | Lavinia Agra Coletto |
| collection | DOAJ |
| description | Spondyloarthritis (SpA) contemplates the inflammatory involvement of the musculoskeletal system, gut, skin, and eyes, delineating heterogeneous diseases with a common pathogenetic background. In the framework of innate and adaptive immune disruption in SpA, neutrophils are arising, across different clinical domains, as pivotal cells crucial in orchestrating the pro-inflammatory response, both at systemic and tissue levels. It has been suggested they act as key players along multiple stages of disease trajectory fueling type 3 immunity, with a significant impact in the initiation and amplification of inflammation as well as in structural damage occurrence, typical of long-standing disease. The aim of our review is to focus on neutrophils’ role within the spectrum of SpA, dissecting their functions and abnormalities in each of the relevant disease domains to understand their rising appeal as potential biomarkers and therapeutic targets. |
| first_indexed | 2024-03-11T08:41:17Z |
| format | Article |
| id | doaj.art-d4eb352a7f3f4c9786db4f407ad6b7ac |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:41:17Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d4eb352a7f3f4c9786db4f407ad6b7ac2023-11-16T21:09:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244410810.3390/ijms24044108The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease ManifestationsLavinia Agra Coletto0Chiara Rizzo1Giuliana Guggino2Roberto Caporali3Stefano Alivernini4Maria Antonietta D’Agostino5Division of Rheumatology, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Section, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology Section, University of Palermo, 90127 Palermo, ItalyDivision of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, 20122 Milan, ItalyDivision of Rheumatology, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, ItalyDivision of Rheumatology, Università Cattolica del Sacro Cuore, Policlinico Universitario Agostino Gemelli IRCSS, 00168 Rome, ItalySpondyloarthritis (SpA) contemplates the inflammatory involvement of the musculoskeletal system, gut, skin, and eyes, delineating heterogeneous diseases with a common pathogenetic background. In the framework of innate and adaptive immune disruption in SpA, neutrophils are arising, across different clinical domains, as pivotal cells crucial in orchestrating the pro-inflammatory response, both at systemic and tissue levels. It has been suggested they act as key players along multiple stages of disease trajectory fueling type 3 immunity, with a significant impact in the initiation and amplification of inflammation as well as in structural damage occurrence, typical of long-standing disease. The aim of our review is to focus on neutrophils’ role within the spectrum of SpA, dissecting their functions and abnormalities in each of the relevant disease domains to understand their rising appeal as potential biomarkers and therapeutic targets.https://www.mdpi.com/1422-0067/24/4/4108spondyloarthritisneutrophilspsoriasisuveitisenthesitisarthritis |
| spellingShingle | Lavinia Agra Coletto Chiara Rizzo Giuliana Guggino Roberto Caporali Stefano Alivernini Maria Antonietta D’Agostino The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations International Journal of Molecular Sciences spondyloarthritis neutrophils psoriasis uveitis enthesitis arthritis |
| title | The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations |
| title_full | The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations |
| title_fullStr | The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations |
| title_full_unstemmed | The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations |
| title_short | The Role of Neutrophils in Spondyloarthritis: A Journey across the Spectrum of Disease Manifestations |
| title_sort | role of neutrophils in spondyloarthritis a journey across the spectrum of disease manifestations |
| topic | spondyloarthritis neutrophils psoriasis uveitis enthesitis arthritis |
| url | https://www.mdpi.com/1422-0067/24/4/4108 |
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