Experimental Animal Models of Arteriovenous Malformation: A Review
Arteriovenous malformations (AVMs) are congenital lesions that cause brain haemorrhage in children and young adults. Current treatment modalities include surgery, radiosurgery and embolization. These treatments are generally effective only for small AVMs. Over one third of AVMs cannot be treated saf...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-06-01
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| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2306-7381/2/2/97 |
| _version_ | 1819177233876516864 |
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| author | Jude Amal Raj Marcus Stoodley |
| author_facet | Jude Amal Raj Marcus Stoodley |
| author_sort | Jude Amal Raj |
| collection | DOAJ |
| description | Arteriovenous malformations (AVMs) are congenital lesions that cause brain haemorrhage in children and young adults. Current treatment modalities include surgery, radiosurgery and embolization. These treatments are generally effective only for small AVMs. Over one third of AVMs cannot be treated safely and effectively with existing options. Several animal models have been developed with the aims of understanding AVM pathophysiology and improving treatment. No animal model perfectly mimics a human AVM. Each model has limitations and advantages. Models contribute to the understanding of AVMs and hopefully to the development of improved therapies. This paper reviews animal models of AVMs and their advantages and disadvantages. |
| first_indexed | 2024-12-22T21:23:24Z |
| format | Article |
| id | doaj.art-d4ecd84356d84b0596dd102b90e36b38 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-12-22T21:23:24Z |
| publishDate | 2015-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-d4ecd84356d84b0596dd102b90e36b382022-12-21T18:12:08ZengMDPI AGVeterinary Sciences2306-73812015-06-01229711010.3390/vetsci2020097vetsci2020097Experimental Animal Models of Arteriovenous Malformation: A ReviewJude Amal Raj0Marcus Stoodley1The Australian School of Advanced Medicine, Macquarie University, NSW 2109, AustraliaThe Australian School of Advanced Medicine, Macquarie University, NSW 2109, AustraliaArteriovenous malformations (AVMs) are congenital lesions that cause brain haemorrhage in children and young adults. Current treatment modalities include surgery, radiosurgery and embolization. These treatments are generally effective only for small AVMs. Over one third of AVMs cannot be treated safely and effectively with existing options. Several animal models have been developed with the aims of understanding AVM pathophysiology and improving treatment. No animal model perfectly mimics a human AVM. Each model has limitations and advantages. Models contribute to the understanding of AVMs and hopefully to the development of improved therapies. This paper reviews animal models of AVMs and their advantages and disadvantages.http://www.mdpi.com/2306-7381/2/2/97cerebral arteriovenous malformationsanimal models |
| spellingShingle | Jude Amal Raj Marcus Stoodley Experimental Animal Models of Arteriovenous Malformation: A Review Veterinary Sciences cerebral arteriovenous malformations animal models |
| title | Experimental Animal Models of Arteriovenous Malformation: A Review |
| title_full | Experimental Animal Models of Arteriovenous Malformation: A Review |
| title_fullStr | Experimental Animal Models of Arteriovenous Malformation: A Review |
| title_full_unstemmed | Experimental Animal Models of Arteriovenous Malformation: A Review |
| title_short | Experimental Animal Models of Arteriovenous Malformation: A Review |
| title_sort | experimental animal models of arteriovenous malformation a review |
| topic | cerebral arteriovenous malformations animal models |
| url | http://www.mdpi.com/2306-7381/2/2/97 |
| work_keys_str_mv | AT judeamalraj experimentalanimalmodelsofarteriovenousmalformationareview AT marcusstoodley experimentalanimalmodelsofarteriovenousmalformationareview |