JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

Abstract Background Loss-of-function (LOF) mutations of JAK1, a member of the JAK kinase family, were frequently observed in EC, indicating that JAK1 may act as a tumor suppressor, at least in EC. However, the mechanism of JAK1 mediated regulation of tumorigenesis remains poorly understood. Methods...

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Bibliographic Details
Main Authors: Qin Lin, Zheng Chen, Wei Shi, Zeheng Lv, Xiaoping Wan, Kun Gao
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cell Communication and Signaling
Subjects:
Endometrial cancer
JAK1
HIF-1α
HIF-2α
Proliferation
Migration
Online Access:https://doi.org/10.1186/s12964-022-00990-5

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