In Vivo Evaluation of a Novel Radiofrequency Ablation Electrode in Pig Livers
(1) Background: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is an alternative treatment for pancreatic tumors. Currently, EUS-RFA has been trialled to treat hepatic tumors. However, little has been reported about optimal settings for EUS-RFA in patients with hepatic tumors. We eva...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/13/6791 |
| _version_ | 1797480775822606336 |
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| author | Sung-Hyun Cho Dongwook Oh Gunn Huh Tae-Jun Song Dong-Wan Seo |
| author_facet | Sung-Hyun Cho Dongwook Oh Gunn Huh Tae-Jun Song Dong-Wan Seo |
| author_sort | Sung-Hyun Cho |
| collection | DOAJ |
| description | (1) Background: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is an alternative treatment for pancreatic tumors. Currently, EUS-RFA has been trialled to treat hepatic tumors. However, little has been reported about optimal settings for EUS-RFA in patients with hepatic tumors. We evaluated the ablation effect after in vivo RFA using a new EUS-RFA electrode in a pig model. (2) Methods Four pigs were used for the in vivo test. The in vivo testing was divided into two tests based on the length of the RFA electrode (0.5, 0.7, 1 or 1.5 cm), the ablation power (30 W or 50 W), and the ablation time (10 or 15 s). In test one, ablation effect was evaluated based on the electrode length and power. In test two, ablation effect was assessed based on power and time. (3) Results: In test one, the ablation width and depth correlated with the length of the electrode and power (0.5 cm, 10 W, 10 s: width 0.46 cm, depth 0.65 cm vs. 1.5 cm, 75 W, 10 s: width 0.77 cm, depth 1.80 cm). In test two, ablation width and depth were similar when RFA was set at 1.5cm, 50 W, and 10 s or 1 cm, 30 W, and 15 s (0.65 cm, 1.14 cm vs. 0.65cm, 1.26 cm). (4) Conclusions: The relationship between electrode length, ablation power, and ablation time, and the resulting ablation effect in pig livers suggest that EUS-RFA produces effective ablation while minimizing thermal injury. |
| first_indexed | 2024-03-09T22:04:57Z |
| format | Article |
| id | doaj.art-d4ef1d85c199444c9aef5e03ee10bb18 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T22:04:57Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-d4ef1d85c199444c9aef5e03ee10bb182023-11-23T19:42:46ZengMDPI AGApplied Sciences2076-34172022-07-011213679110.3390/app12136791In Vivo Evaluation of a Novel Radiofrequency Ablation Electrode in Pig LiversSung-Hyun Cho0Dongwook Oh1Gunn Huh2Tae-Jun Song3Dong-Wan Seo4Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, KoreaDepartment of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, KoreaDepartment of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, KoreaDepartment of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, KoreaDepartment of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea(1) Background: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is an alternative treatment for pancreatic tumors. Currently, EUS-RFA has been trialled to treat hepatic tumors. However, little has been reported about optimal settings for EUS-RFA in patients with hepatic tumors. We evaluated the ablation effect after in vivo RFA using a new EUS-RFA electrode in a pig model. (2) Methods Four pigs were used for the in vivo test. The in vivo testing was divided into two tests based on the length of the RFA electrode (0.5, 0.7, 1 or 1.5 cm), the ablation power (30 W or 50 W), and the ablation time (10 or 15 s). In test one, ablation effect was evaluated based on the electrode length and power. In test two, ablation effect was assessed based on power and time. (3) Results: In test one, the ablation width and depth correlated with the length of the electrode and power (0.5 cm, 10 W, 10 s: width 0.46 cm, depth 0.65 cm vs. 1.5 cm, 75 W, 10 s: width 0.77 cm, depth 1.80 cm). In test two, ablation width and depth were similar when RFA was set at 1.5cm, 50 W, and 10 s or 1 cm, 30 W, and 15 s (0.65 cm, 1.14 cm vs. 0.65cm, 1.26 cm). (4) Conclusions: The relationship between electrode length, ablation power, and ablation time, and the resulting ablation effect in pig livers suggest that EUS-RFA produces effective ablation while minimizing thermal injury.https://www.mdpi.com/2076-3417/12/13/6791endoscopic ultrasoundradiofrequency ablationliveranimalsswine |
| spellingShingle | Sung-Hyun Cho Dongwook Oh Gunn Huh Tae-Jun Song Dong-Wan Seo In Vivo Evaluation of a Novel Radiofrequency Ablation Electrode in Pig Livers Applied Sciences endoscopic ultrasound radiofrequency ablation liver animals swine |
| title | In Vivo Evaluation of a Novel Radiofrequency Ablation Electrode in Pig Livers |
| title_full | In Vivo Evaluation of a Novel Radiofrequency Ablation Electrode in Pig Livers |
| title_fullStr | In Vivo Evaluation of a Novel Radiofrequency Ablation Electrode in Pig Livers |
| title_full_unstemmed | In Vivo Evaluation of a Novel Radiofrequency Ablation Electrode in Pig Livers |
| title_short | In Vivo Evaluation of a Novel Radiofrequency Ablation Electrode in Pig Livers |
| title_sort | in vivo evaluation of a novel radiofrequency ablation electrode in pig livers |
| topic | endoscopic ultrasound radiofrequency ablation liver animals swine |
| url | https://www.mdpi.com/2076-3417/12/13/6791 |
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