Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection
Inflammation is a key factor in the development of atherosclerosis, a disease characterized by the buildup of plaque in the arteries. COVID-19 infection is known to cause systemic inflammation, but its impact on local plaque vulnerability is unclear. Our study aimed to investigate the impact of COVI...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7398 |
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| author | Botond Barna Mátyás Imre Benedek Emanuel Blîndu Renáta Gerculy Aurelian Roșca Nóra Rat István Kovács Diana Opincariu Zsolt Parajkó Evelin Szabó Bianka Benedek Theodora Benedek |
| author_facet | Botond Barna Mátyás Imre Benedek Emanuel Blîndu Renáta Gerculy Aurelian Roșca Nóra Rat István Kovács Diana Opincariu Zsolt Parajkó Evelin Szabó Bianka Benedek Theodora Benedek |
| author_sort | Botond Barna Mátyás |
| collection | DOAJ |
| description | Inflammation is a key factor in the development of atherosclerosis, a disease characterized by the buildup of plaque in the arteries. COVID-19 infection is known to cause systemic inflammation, but its impact on local plaque vulnerability is unclear. Our study aimed to investigate the impact of COVID-19 infection on coronary artery disease (CAD) in patients who underwent computed tomography angiography (CCTA) for chest pain in the early stages after infection, using an AI-powered solution called CaRi-Heart<sup>®</sup>. The study included 158 patients (mean age was 61.63 ± 10.14 years) with angina and low to intermediate clinical likelihood of CAD, with 75 having a previous COVID-19 infection and 83 without infection. The results showed that patients who had a previous COVID-19 infection had higher levels of pericoronary inflammation than those who did not have a COVID-19 infection, suggesting that COVID-19 may increase the risk of coronary plaque destabilization. This study highlights the potential long-term impact of COVID-19 on cardiovascular health, and the importance of monitoring and managing cardiovascular risk factors in patients recovering from COVID-19 infection. The AI-powered CaRi-Heart<sup>®</sup> technology may offer a non-invasive way to detect coronary artery inflammation and plaque instability in patients with COVID-19. |
| first_indexed | 2024-03-11T04:56:32Z |
| format | Article |
| id | doaj.art-d4f00c8389494492baae91e24f4dbf89 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:56:32Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d4f00c8389494492baae91e24f4dbf892023-11-17T19:39:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248739810.3390/ijms24087398Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 InfectionBotond Barna Mátyás0Imre Benedek1Emanuel Blîndu2Renáta Gerculy3Aurelian Roșca4Nóra Rat5István Kovács6Diana Opincariu7Zsolt Parajkó8Evelin Szabó9Bianka Benedek10Theodora Benedek11Clinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaCenter of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, 540124 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaFaculty of Medicine and Pharmacy, University of Medicine, Pharmacy, Science and Technology “George Emil Palade” of Târgu-Mures, 540139 Târgu Mureș, RomaniaClinic of Cardiology, Mureș County Emergency Clinical Hospital, 540142 Târgu Mureș, RomaniaInflammation is a key factor in the development of atherosclerosis, a disease characterized by the buildup of plaque in the arteries. COVID-19 infection is known to cause systemic inflammation, but its impact on local plaque vulnerability is unclear. Our study aimed to investigate the impact of COVID-19 infection on coronary artery disease (CAD) in patients who underwent computed tomography angiography (CCTA) for chest pain in the early stages after infection, using an AI-powered solution called CaRi-Heart<sup>®</sup>. The study included 158 patients (mean age was 61.63 ± 10.14 years) with angina and low to intermediate clinical likelihood of CAD, with 75 having a previous COVID-19 infection and 83 without infection. The results showed that patients who had a previous COVID-19 infection had higher levels of pericoronary inflammation than those who did not have a COVID-19 infection, suggesting that COVID-19 may increase the risk of coronary plaque destabilization. This study highlights the potential long-term impact of COVID-19 on cardiovascular health, and the importance of monitoring and managing cardiovascular risk factors in patients recovering from COVID-19 infection. The AI-powered CaRi-Heart<sup>®</sup> technology may offer a non-invasive way to detect coronary artery inflammation and plaque instability in patients with COVID-19.https://www.mdpi.com/1422-0067/24/8/7398COVID-19vascular inflammationfat attenuation indexplaque vulnerabilitythrombosischronic coronary syndrome |
| spellingShingle | Botond Barna Mátyás Imre Benedek Emanuel Blîndu Renáta Gerculy Aurelian Roșca Nóra Rat István Kovács Diana Opincariu Zsolt Parajkó Evelin Szabó Bianka Benedek Theodora Benedek Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection International Journal of Molecular Sciences COVID-19 vascular inflammation fat attenuation index plaque vulnerability thrombosis chronic coronary syndrome |
| title | Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection |
| title_full | Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection |
| title_fullStr | Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection |
| title_full_unstemmed | Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection |
| title_short | Elevated FAI Index of Pericoronary Inflammation on Coronary CT Identifies Increased Risk of Coronary Plaque Vulnerability after COVID-19 Infection |
| title_sort | elevated fai index of pericoronary inflammation on coronary ct identifies increased risk of coronary plaque vulnerability after covid 19 infection |
| topic | COVID-19 vascular inflammation fat attenuation index plaque vulnerability thrombosis chronic coronary syndrome |
| url | https://www.mdpi.com/1422-0067/24/8/7398 |
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