PEG-8 Laurate Fermentation of <i>Staphylococcus epidermidis</i> Reduces the Required Dose of Clindamycin Against <i>Cutibacterium acnes</i>
The probiotic activity of skin <i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>) bacteria can elicit diverse biological functions via the fermentation of various carbon sources. Here, we found that polyethylene glycol (PEG)-8 Laurate, a carbon-rich molecule, can selec...
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MDPI AG
2020-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/14/5103 |
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| author | Shinta Marito Sunita Keshari Chun-Ming Huang |
| author_facet | Shinta Marito Sunita Keshari Chun-Ming Huang |
| author_sort | Shinta Marito |
| collection | DOAJ |
| description | The probiotic activity of skin <i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>) bacteria can elicit diverse biological functions via the fermentation of various carbon sources. Here, we found that polyethylene glycol (PEG)-8 Laurate, a carbon-rich molecule, can selectively induce the fermentation of <i>S. epidermidis</i>, not <i>Cutibacterium acnes</i> (<i>C. acnes</i>), a bacterium associated with acne vulgaris. The PEG-8 Laurate fermentation of <i>S. epidermidis</i> remarkably diminished the growth of <i>C. acnes</i> and the <i>C. acnes</i>-induced production of pro-inflammatory macrophage-inflammatory protein 2 (MIP-2) cytokines in mice. Fermentation media enhanced the anti-<i>C. acnes</i> activity of a low dose (0.1%) clindamycin, a prescription antibiotic commonly used to treat acne vulgaris, in terms of the suppression of <i>C. acnes</i> colonization and MIP-2 production. Furthermore, PEG-8 Laurate fermentation of <i>S. epidermidis</i> boosted the activity of 0.1% clindamycin to reduce the sizes of <i>C. acnes</i> colonies. Our results demonstrated, for the first time, that the PEG-8 Laurate fermentation of <i>S. epidermidis</i> displayed the adjuvant effect on promoting the efficacy of low-dose clindamycin against <i>C. acnes</i>. Targeting <i>C. acnes</i> by lowering the required doses of antibiotics may avoid the risk of creating drug-resistant <i>C. acnes</i> and maintain the bacterial homeostasis in the skin microbiome, leading to a novel modality for the antibiotic treatment of acne vulgaris. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T18:23:10Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d4f03c1dc59d4ac49f392c00ee4da9ef2023-11-20T07:16:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012114510310.3390/ijms21145103PEG-8 Laurate Fermentation of <i>Staphylococcus epidermidis</i> Reduces the Required Dose of Clindamycin Against <i>Cutibacterium acnes</i>Shinta Marito0Sunita Keshari1Chun-Ming Huang2Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 32001, TaiwanDepartment of Life Sciences, National Central University, Taoyuan 32001, TaiwanDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan 32001, TaiwanThe probiotic activity of skin <i>Staphylococcus epidermidis</i> (<i>S. epidermidis</i>) bacteria can elicit diverse biological functions via the fermentation of various carbon sources. Here, we found that polyethylene glycol (PEG)-8 Laurate, a carbon-rich molecule, can selectively induce the fermentation of <i>S. epidermidis</i>, not <i>Cutibacterium acnes</i> (<i>C. acnes</i>), a bacterium associated with acne vulgaris. The PEG-8 Laurate fermentation of <i>S. epidermidis</i> remarkably diminished the growth of <i>C. acnes</i> and the <i>C. acnes</i>-induced production of pro-inflammatory macrophage-inflammatory protein 2 (MIP-2) cytokines in mice. Fermentation media enhanced the anti-<i>C. acnes</i> activity of a low dose (0.1%) clindamycin, a prescription antibiotic commonly used to treat acne vulgaris, in terms of the suppression of <i>C. acnes</i> colonization and MIP-2 production. Furthermore, PEG-8 Laurate fermentation of <i>S. epidermidis</i> boosted the activity of 0.1% clindamycin to reduce the sizes of <i>C. acnes</i> colonies. Our results demonstrated, for the first time, that the PEG-8 Laurate fermentation of <i>S. epidermidis</i> displayed the adjuvant effect on promoting the efficacy of low-dose clindamycin against <i>C. acnes</i>. Targeting <i>C. acnes</i> by lowering the required doses of antibiotics may avoid the risk of creating drug-resistant <i>C. acnes</i> and maintain the bacterial homeostasis in the skin microbiome, leading to a novel modality for the antibiotic treatment of acne vulgaris.https://www.mdpi.com/1422-0067/21/14/5103adjuvant<i>C. acnes</i>clindamycinPEG-8 Laurate<i>S. epidermidis</i> |
| spellingShingle | Shinta Marito Sunita Keshari Chun-Ming Huang PEG-8 Laurate Fermentation of <i>Staphylococcus epidermidis</i> Reduces the Required Dose of Clindamycin Against <i>Cutibacterium acnes</i> International Journal of Molecular Sciences adjuvant <i>C. acnes</i> clindamycin PEG-8 Laurate <i>S. epidermidis</i> |
| title | PEG-8 Laurate Fermentation of <i>Staphylococcus epidermidis</i> Reduces the Required Dose of Clindamycin Against <i>Cutibacterium acnes</i> |
| title_full | PEG-8 Laurate Fermentation of <i>Staphylococcus epidermidis</i> Reduces the Required Dose of Clindamycin Against <i>Cutibacterium acnes</i> |
| title_fullStr | PEG-8 Laurate Fermentation of <i>Staphylococcus epidermidis</i> Reduces the Required Dose of Clindamycin Against <i>Cutibacterium acnes</i> |
| title_full_unstemmed | PEG-8 Laurate Fermentation of <i>Staphylococcus epidermidis</i> Reduces the Required Dose of Clindamycin Against <i>Cutibacterium acnes</i> |
| title_short | PEG-8 Laurate Fermentation of <i>Staphylococcus epidermidis</i> Reduces the Required Dose of Clindamycin Against <i>Cutibacterium acnes</i> |
| title_sort | peg 8 laurate fermentation of i staphylococcus epidermidis i reduces the required dose of clindamycin against i cutibacterium acnes i |
| topic | adjuvant <i>C. acnes</i> clindamycin PEG-8 Laurate <i>S. epidermidis</i> |
| url | https://www.mdpi.com/1422-0067/21/14/5103 |
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