Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study
Introduction: The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer’s disease (AD) is that of a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed in early stages of AD. Aβ distribution on PET has previously been explored in MCI and AD, but it has yet...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Aging Brain |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589958922000202 |
| _version_ | 1811197441182007296 |
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| author | Pernille L. Kjeldsen Peter Parbo Kim V. Hansen Joel F.A. Aanerud Rola Ismail Peter H. Nissen Rikke B. Dalby Malene F. Damholdt Per Borghammer David J. Brooks |
| author_facet | Pernille L. Kjeldsen Peter Parbo Kim V. Hansen Joel F.A. Aanerud Rola Ismail Peter H. Nissen Rikke B. Dalby Malene F. Damholdt Per Borghammer David J. Brooks |
| author_sort | Pernille L. Kjeldsen |
| collection | DOAJ |
| description | Introduction: The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer’s disease (AD) is that of a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed in early stages of AD. Aβ distribution on PET has previously been explored in MCI and AD, but it has yet to be directly investigated in preclinical AD (pAD). We examined how Aβ was distributed in individuals with pAD and MCI using 11C-Pittsburgh Compound B (PiB) PET. Methods: In this PET study, 79 subjects were retrospectively enrolled, including 34 controls, 24 pAD, and 21 MCI. All subjects underwent APOE genotyping, 11C-PiB PET, MRI, and cognitive testing. We explored differences in Aβ load, Aβ lateralisation, and Aβ distribution, as well as associations between Aβ distribution and cognition. Results: The Aβ asymmetry index (AI) differed between groups, with pAD having the highest Aβ AI as compared to both controls and MCI. There was no clear Aβ lateralisation in pAD, but there was a non-significant trend towards Aβ being more left-lateralised in MCI. There were no correlations between the cognitive scores and Aβ AI or Aβ lateralisation in pAD or MCI. Conclusion: The distribution of Aβ is most asymmetrical in pAD, as Aβ first starts accumulating, and it then becomes less asymmetrical in MCI, when Aβ has spread further, suggesting that more pronounced asymmetrical Aβ distribution may be a distinguishing factor in pAD. Longitudinal studies examining the distribution of Aβ across the AD continuum are needed. |
| first_indexed | 2024-04-12T01:13:42Z |
| format | Article |
| id | doaj.art-d4f233cd10d145528054e34755010fb9 |
| institution | Directory Open Access Journal |
| issn | 2589-9589 |
| language | English |
| last_indexed | 2024-04-12T01:13:42Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aging Brain |
| spelling | doaj.art-d4f233cd10d145528054e34755010fb92022-12-22T03:54:01ZengElsevierAging Brain2589-95892022-01-012100048Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET studyPernille L. Kjeldsen0Peter Parbo1Kim V. Hansen2Joel F.A. Aanerud3Rola Ismail4Peter H. Nissen5Rikke B. Dalby6Malene F. Damholdt7Per Borghammer8David J. Brooks9Dept. of Clinical Medicine, Aarhus University, Denmark; Dept. of Nuclear Medicine and PET, Aarhus University Hospital, DenmarkDept. of Clinical Medicine, Aarhus University, Denmark; Dept. of Nuclear Medicine, Odense University Hospital, DenmarkDept. of Nuclear Medicine and PET, Aarhus University Hospital, DenmarkDept. of Nuclear Medicine and PET, Aarhus University Hospital, DenmarkDept. of Nuclear Medicine, Vejle, Lillebælt Hospital, DenmarkDept. of Clinical Medicine, Aarhus University, Denmark; Dept. of Clinical Biochemistry, Aarhus University Hospital, DenmarkDept. of Clinical Medicine, Aarhus University, Denmark; Dept. of Radiology, Section for Neuroradiology, Aarhus University Hospital, Denmark; Centre for Functionally Integrative Neuroscience, Aarhus University, DenmarkDept. of Clinical Medicine, Aarhus University, Denmark; Dept. of Psychology, Aarhus University, DenmarkDept. of Clinical Medicine, Aarhus University, Denmark; Dept. of Nuclear Medicine and PET, Aarhus University Hospital, DenmarkDept. of Clinical Medicine, Aarhus University, Denmark; Dept. of Nuclear Medicine and PET, Aarhus University Hospital, Denmark; Translational and Clinical Research Institute, Newcastle University, United KingdomIntroduction: The typical spatial pattern of amyloid-β (Aβ) in diagnosed Alzheimer’s disease (AD) is that of a symmetrical hemispheric distribution. However, Aβ may be asymmetrically distributed in early stages of AD. Aβ distribution on PET has previously been explored in MCI and AD, but it has yet to be directly investigated in preclinical AD (pAD). We examined how Aβ was distributed in individuals with pAD and MCI using 11C-Pittsburgh Compound B (PiB) PET. Methods: In this PET study, 79 subjects were retrospectively enrolled, including 34 controls, 24 pAD, and 21 MCI. All subjects underwent APOE genotyping, 11C-PiB PET, MRI, and cognitive testing. We explored differences in Aβ load, Aβ lateralisation, and Aβ distribution, as well as associations between Aβ distribution and cognition. Results: The Aβ asymmetry index (AI) differed between groups, with pAD having the highest Aβ AI as compared to both controls and MCI. There was no clear Aβ lateralisation in pAD, but there was a non-significant trend towards Aβ being more left-lateralised in MCI. There were no correlations between the cognitive scores and Aβ AI or Aβ lateralisation in pAD or MCI. Conclusion: The distribution of Aβ is most asymmetrical in pAD, as Aβ first starts accumulating, and it then becomes less asymmetrical in MCI, when Aβ has spread further, suggesting that more pronounced asymmetrical Aβ distribution may be a distinguishing factor in pAD. Longitudinal studies examining the distribution of Aβ across the AD continuum are needed.http://www.sciencedirect.com/science/article/pii/S2589958922000202Preclinical Alzheimer’s diseasePositron emission tomographyAmyloid depositionAsymmetry |
| spellingShingle | Pernille L. Kjeldsen Peter Parbo Kim V. Hansen Joel F.A. Aanerud Rola Ismail Peter H. Nissen Rikke B. Dalby Malene F. Damholdt Per Borghammer David J. Brooks Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study Aging Brain Preclinical Alzheimer’s disease Positron emission tomography Amyloid deposition Asymmetry |
| title | Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study |
| title_full | Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study |
| title_fullStr | Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study |
| title_full_unstemmed | Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study |
| title_short | Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study |
| title_sort | asymmetric amyloid deposition in preclinical alzheimer s disease a pet study |
| topic | Preclinical Alzheimer’s disease Positron emission tomography Amyloid deposition Asymmetry |
| url | http://www.sciencedirect.com/science/article/pii/S2589958922000202 |
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