UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling

UCP2 silencing restrains leukemia cell proliferation through glutamine metabolic remodeling

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T cell progenitors. Since relapsed T-ALL is associated with a poor prognosis improving initial treatment of patients is essential to avoid resistant selection of T-ALL. During initiation, developme...

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Bibliographic Details
Main Authors: Tiphaine Sancerni, Ophélie Renoult, Angèle Luby, Cédric Caradeuc, Véronique Lenoir, Mikael Croyal, Céline Ransy, Esther Aguilar, Catherine Postic, Gildas Bertho, Renaud Dentin, Carina Prip-Buus, Claire Pecqueur, Marie-Clotilde Alves-Guerra
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
metabolism rewiring
leukemia
mitochondria
glutamine
UCP2
metabolite carrier
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.960226/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.960226/full

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