Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization
C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past few years, mainly, the C–H functionalization system in (hetero)aryl C–H activation owing to the impor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2023-05-01
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| Series: | Green Synthesis and Catalysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666554922001363 |
| _version_ | 1797809807073214464 |
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| author | Weidong Shang Hongbao Sun Wei Chen Jie Liu |
| author_facet | Weidong Shang Hongbao Sun Wei Chen Jie Liu |
| author_sort | Weidong Shang |
| collection | DOAJ |
| description | C–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past few years, mainly, the C–H functionalization system in (hetero)aryl C–H activation owing to the importance of (hetero)aryl moiety in pharmaceutical. In this review, we described the selected recent examples of how developed intermolecular C(sp2)–H functionalization methodologies involving diverse techniques diversify pharmaceutical molecules in the late stage. |
| first_indexed | 2024-03-13T06:58:21Z |
| format | Article |
| id | doaj.art-d4f4e774efc14d11982e8d64f28d591d |
| institution | Directory Open Access Journal |
| issn | 2666-5549 |
| language | English |
| last_indexed | 2024-03-13T06:58:21Z |
| publishDate | 2023-05-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Green Synthesis and Catalysis |
| spelling | doaj.art-d4f4e774efc14d11982e8d64f28d591d2023-06-07T04:49:56ZengKeAi Communications Co. Ltd.Green Synthesis and Catalysis2666-55492023-05-0142104123Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalizationWeidong Shang0Hongbao Sun1Wei Chen2Jie Liu3Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Huaxi MR Research Center, Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, ChinaTargeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Huaxi MR Research Center, Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, ChinaCorresponding author.; Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Huaxi MR Research Center, Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, ChinaCorresponding author.; Targeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Huaxi MR Research Center, Laboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, ChinaC–H late-stage functionalization has gradually become a powerful approach for the rapid optimization of lead compounds’ bioactivity. Significant advances in this field have been achieved in the past few years, mainly, the C–H functionalization system in (hetero)aryl C–H activation owing to the importance of (hetero)aryl moiety in pharmaceutical. In this review, we described the selected recent examples of how developed intermolecular C(sp2)–H functionalization methodologies involving diverse techniques diversify pharmaceutical molecules in the late stage.http://www.sciencedirect.com/science/article/pii/S2666554922001363C–H FunctionalizationSynthetic toolLate-stage functionalizationPharmaceutical molecules |
| spellingShingle | Weidong Shang Hongbao Sun Wei Chen Jie Liu Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization Green Synthesis and Catalysis C–H Functionalization Synthetic tool Late-stage functionalization Pharmaceutical molecules |
| title | Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization |
| title_full | Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization |
| title_fullStr | Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization |
| title_full_unstemmed | Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization |
| title_short | Diversification of pharmaceutical molecules via late-stage C(sp2)–H functionalization |
| title_sort | diversification of pharmaceutical molecules via late stage c sp2 h functionalization |
| topic | C–H Functionalization Synthetic tool Late-stage functionalization Pharmaceutical molecules |
| url | http://www.sciencedirect.com/science/article/pii/S2666554922001363 |
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