Ethiological treatment of acute and chronic Chagas' heart disease
The uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the in...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Associação Paulista de Medicina
|
| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200020&lng=en&tlng=en |
| _version_ | 1819268442445840384 |
|---|---|
| author | Abílio Augusto Fragata Filho Marco Aurélio Dias da Silva Elias Boainain |
| author_facet | Abílio Augusto Fragata Filho Marco Aurélio Dias da Silva Elias Boainain |
| author_sort | Abílio Augusto Fragata Filho |
| collection | DOAJ |
| description | The uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunossuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardiac/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg/kg/day, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment. It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium. |
| first_indexed | 2024-12-23T21:33:08Z |
| format | Article |
| id | doaj.art-d4f6d122656b493e880e005398a69fc7 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-23T21:33:08Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-d4f6d122656b493e880e005398a69fc72022-12-21T17:30:23ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460113286787210.1590/S1516-31801995000200020S1516-31801995000200020Ethiological treatment of acute and chronic Chagas' heart diseaseAbílio Augusto Fragata Filho0Marco Aurélio Dias da Silva1Elias Boainain2Instituto Dante Pazzanese de CardiologiaInstituto Dante Pazzanese de CardiologiaInstituto Dante Pazzanese de CardiologiaThe uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunossuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardiac/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg/kg/day, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment. It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200020&lng=en&tlng=enChagas's diseaseBenzonidazolCardiomyopathies |
| spellingShingle | Abílio Augusto Fragata Filho Marco Aurélio Dias da Silva Elias Boainain Ethiological treatment of acute and chronic Chagas' heart disease São Paulo Medical Journal Chagas's disease Benzonidazol Cardiomyopathies |
| title | Ethiological treatment of acute and chronic Chagas' heart disease |
| title_full | Ethiological treatment of acute and chronic Chagas' heart disease |
| title_fullStr | Ethiological treatment of acute and chronic Chagas' heart disease |
| title_full_unstemmed | Ethiological treatment of acute and chronic Chagas' heart disease |
| title_short | Ethiological treatment of acute and chronic Chagas' heart disease |
| title_sort | ethiological treatment of acute and chronic chagas heart disease |
| topic | Chagas's disease Benzonidazol Cardiomyopathies |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000200020&lng=en&tlng=en |
| work_keys_str_mv | AT abilioaugustofragatafilho ethiologicaltreatmentofacuteandchronicchagasheartdisease AT marcoaureliodiasdasilva ethiologicaltreatmentofacuteandchronicchagasheartdisease AT eliasboainain ethiologicaltreatmentofacuteandchronicchagasheartdisease |