Patterns of HIV/SIV prevention and control by passive antibody immunization
Neutralizing antibody (NAb) responses are promising immune effectors for control of human immunodeficiency virus (HIV) infection. Protective activity and mechanisms of immunodeficiency virus-specific NAbs have been increasingly scrutinized in animals infected with simian immunodeficiency virus (SIV)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01739/full |
| _version_ | 1819207885816594432 |
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| author | Hiroyuki Yamamoto Tetsuro Matano Tetsuro Matano |
| author_facet | Hiroyuki Yamamoto Tetsuro Matano Tetsuro Matano |
| author_sort | Hiroyuki Yamamoto |
| collection | DOAJ |
| description | Neutralizing antibody (NAb) responses are promising immune effectors for control of human immunodeficiency virus (HIV) infection. Protective activity and mechanisms of immunodeficiency virus-specific NAbs have been increasingly scrutinized in animals infected with simian immunodeficiency virus (SIV), chimeric simian/human immunodeficiency virus (SHIV) and related viruses. Studies on such models have unraveled a previously underscored protective potential against in vivo immunodeficiency virus replication. Pre-challenge NAb titers feasibly provide sterile protection from SIV/SHIV infection by purging the earliest onset of viral replication and likely modulate innate immune cell responses. Sufficient sub-sterile NAb titers after established infection also confer dose-dependent reduction of viremia, and in certain earlier time frames augment adaptive immune cell responses and even provide rebound-free viral control. Here, we provide an overview of the obtained patterns of SIV/SHIV protection and viral control by various types of NAb passive immunizations and discuss how these notions may be extrapolated to NAb-based clinical control of HIV infection. |
| first_indexed | 2024-12-23T05:30:36Z |
| format | Article |
| id | doaj.art-d4f71c9a08ed4d26b0cd8bba96fb0305 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-23T05:30:36Z |
| publishDate | 2016-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-d4f71c9a08ed4d26b0cd8bba96fb03052022-12-21T17:58:29ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-11-01710.3389/fmicb.2016.01739231109Patterns of HIV/SIV prevention and control by passive antibody immunizationHiroyuki Yamamoto0Tetsuro Matano1Tetsuro Matano2AIDS Research Center, National Institute of Infectious DiseasesAIDS Research Center, National Institute of Infectious DiseasesThe Institute of Medical Science, The University of TokyoNeutralizing antibody (NAb) responses are promising immune effectors for control of human immunodeficiency virus (HIV) infection. Protective activity and mechanisms of immunodeficiency virus-specific NAbs have been increasingly scrutinized in animals infected with simian immunodeficiency virus (SIV), chimeric simian/human immunodeficiency virus (SHIV) and related viruses. Studies on such models have unraveled a previously underscored protective potential against in vivo immunodeficiency virus replication. Pre-challenge NAb titers feasibly provide sterile protection from SIV/SHIV infection by purging the earliest onset of viral replication and likely modulate innate immune cell responses. Sufficient sub-sterile NAb titers after established infection also confer dose-dependent reduction of viremia, and in certain earlier time frames augment adaptive immune cell responses and even provide rebound-free viral control. Here, we provide an overview of the obtained patterns of SIV/SHIV protection and viral control by various types of NAb passive immunizations and discuss how these notions may be extrapolated to NAb-based clinical control of HIV infection.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01739/fullHIVCD8+ T cellsneutralizing antibodiesSIVpassive immunization |
| spellingShingle | Hiroyuki Yamamoto Tetsuro Matano Tetsuro Matano Patterns of HIV/SIV prevention and control by passive antibody immunization Frontiers in Microbiology HIV CD8+ T cells neutralizing antibodies SIV passive immunization |
| title | Patterns of HIV/SIV prevention and control by passive antibody immunization |
| title_full | Patterns of HIV/SIV prevention and control by passive antibody immunization |
| title_fullStr | Patterns of HIV/SIV prevention and control by passive antibody immunization |
| title_full_unstemmed | Patterns of HIV/SIV prevention and control by passive antibody immunization |
| title_short | Patterns of HIV/SIV prevention and control by passive antibody immunization |
| title_sort | patterns of hiv siv prevention and control by passive antibody immunization |
| topic | HIV CD8+ T cells neutralizing antibodies SIV passive immunization |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01739/full |
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