The emerging role of PPAR-alpha in breast cancer
Breast cancer has been confirmed to have lipid disorders in the tumour microenvironment. Peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPARα regulates the expression of genes involved in fatty ac...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223002081 |
| _version_ | 1797857781185773568 |
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| author | Zhiwen Qian Lingyan Chen Jiayu Liu Ying Jiang Yan Zhang |
| author_facet | Zhiwen Qian Lingyan Chen Jiayu Liu Ying Jiang Yan Zhang |
| author_sort | Zhiwen Qian |
| collection | DOAJ |
| description | Breast cancer has been confirmed to have lipid disorders in the tumour microenvironment. Peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPARα regulates the expression of genes involved in fatty acid homeostasis and is a major regulator of lipid metabolism. Because of its effects on lipid metabolism, an increasing number of studies have investigated the relationship of PPARα with breast cancer. PPARα has been shown to impact the cell cycle and apoptosis in normal cells and tumoral cells through regulating genes of the lipogenic pathway, fatty acid oxidation, fatty acid activation, and uptake of exogenous fatty acids. Besides, PPARα is involved in the regulation of the tumour microenvironment (anti-inflammation and inhibition of angiogenesis) by modulating different signal pathways such as NF-κB and PI3K/AKT/mTOR. Some synthetic PPARα ligands are used in adjuvant therapy for breast cancer. PPARα agonists are reported to reduce the side effects of chemotherapy and endocrine therapy. In addition, PPARα agonists enhance the curative effects of targeted therapy and radiation therapy. Interestingly, with the emerging role of immunotherapy, attention has been focused on the tumour microenvironment. The dual functions of PPARα agonists in immunotherapy need further research. This review aims to consolidate the operations of PPARα in lipid-related and other ways, as well as discuss the current and potential applications of PPARα agonists in tackling breast cancer. |
| first_indexed | 2024-04-09T21:02:20Z |
| format | Article |
| id | doaj.art-d4fab336ba3b4ad39416506bfa93ef02 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-09T21:02:20Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-d4fab336ba3b4ad39416506bfa93ef022023-03-29T09:21:20ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-05-01161114420The emerging role of PPAR-alpha in breast cancerZhiwen Qian0Lingyan Chen1Jiayu Liu2Ying Jiang3Yan Zhang4Department of Oncology, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, ChinaDepartment of Oncology, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, ChinaWuxi Maternal and Child Health Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, ChinaWuxi Maternal and Child Health Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, ChinaDepartment of Oncology, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi 214002, China; Wuxi Maternal and Child Health Hospital, Wuxi School of Medicine, Jiangnan University, Wuxi 214000, China; Correspondence to: Department of Oncology, Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University, No. 48 Huaishu Road, Wuxi 214000, China.Breast cancer has been confirmed to have lipid disorders in the tumour microenvironment. Peroxisome proliferator-activated receptor alpha (PPARα) is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPARα regulates the expression of genes involved in fatty acid homeostasis and is a major regulator of lipid metabolism. Because of its effects on lipid metabolism, an increasing number of studies have investigated the relationship of PPARα with breast cancer. PPARα has been shown to impact the cell cycle and apoptosis in normal cells and tumoral cells through regulating genes of the lipogenic pathway, fatty acid oxidation, fatty acid activation, and uptake of exogenous fatty acids. Besides, PPARα is involved in the regulation of the tumour microenvironment (anti-inflammation and inhibition of angiogenesis) by modulating different signal pathways such as NF-κB and PI3K/AKT/mTOR. Some synthetic PPARα ligands are used in adjuvant therapy for breast cancer. PPARα agonists are reported to reduce the side effects of chemotherapy and endocrine therapy. In addition, PPARα agonists enhance the curative effects of targeted therapy and radiation therapy. Interestingly, with the emerging role of immunotherapy, attention has been focused on the tumour microenvironment. The dual functions of PPARα agonists in immunotherapy need further research. This review aims to consolidate the operations of PPARα in lipid-related and other ways, as well as discuss the current and potential applications of PPARα agonists in tackling breast cancer.http://www.sciencedirect.com/science/article/pii/S0753332223002081PPARαBreast cancerLipid metabolismImmunotherapyTumor microenvironment |
| spellingShingle | Zhiwen Qian Lingyan Chen Jiayu Liu Ying Jiang Yan Zhang The emerging role of PPAR-alpha in breast cancer Biomedicine & Pharmacotherapy PPARα Breast cancer Lipid metabolism Immunotherapy Tumor microenvironment |
| title | The emerging role of PPAR-alpha in breast cancer |
| title_full | The emerging role of PPAR-alpha in breast cancer |
| title_fullStr | The emerging role of PPAR-alpha in breast cancer |
| title_full_unstemmed | The emerging role of PPAR-alpha in breast cancer |
| title_short | The emerging role of PPAR-alpha in breast cancer |
| title_sort | emerging role of ppar alpha in breast cancer |
| topic | PPARα Breast cancer Lipid metabolism Immunotherapy Tumor microenvironment |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223002081 |
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