The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial
Introduction Trehalose is a naturally occurring disaccharide of 2 glucose molecules, which has been suggested as a potential therapeutic agent to reduce blood glucose and ameliorate diabetes-related complications in type 2 diabetes (T2D). This study aimed to determine the efficacy of medium-term tre...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2023-01-01
|
| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/The-effects-of-oral-trehalose-on-glycaemia-inflammation-and-quality-of-life-in-patients,159048,0,2.html |
| _version_ | 1797435486152687616 |
|---|---|
| author | Somayyeh Hashemian Mehrnaz Shojaei Shabnam Radbakhsh Sorour Ashari Maryam Matbou Riahi Zeinab Shateri Amiri Stephen L. Atkin Maciej Banach Mohammad Bagherniya Seyed Ahmad Emami Amirhossein Sahebkar |
| author_facet | Somayyeh Hashemian Mehrnaz Shojaei Shabnam Radbakhsh Sorour Ashari Maryam Matbou Riahi Zeinab Shateri Amiri Stephen L. Atkin Maciej Banach Mohammad Bagherniya Seyed Ahmad Emami Amirhossein Sahebkar |
| author_sort | Somayyeh Hashemian |
| collection | DOAJ |
| description | Introduction
Trehalose is a naturally occurring disaccharide of 2 glucose molecules, which has been suggested as a potential therapeutic agent to reduce blood glucose and ameliorate diabetes-related complications in type 2 diabetes (T2D). This study aimed to determine the efficacy of medium-term trehalose treatment in patients with T2D.
Material and methods
A double-blind, randomized, placebo-controlled trial in 40 patients with T2D was undertaken; 20 ingested trehalose 3.3 g/day and 20 placebo (sucrose), for 3 months. Parameters of glycaemic indices, high-sensitivity C-reactive protein (CRP), mood status, and quality of life were measured.
Results
CRP was significantly lower with trehalose treatment (–0.62 ±0.3 mg/l, p = 0.02); however, no differences in glycaemic indices of fasting blood glucose (FBG) (–7.1 ±10.7 mg/dl, p = 0.15), glycated hemoglobin (HbA1c) (–0.1 ±0.4%, p = 0.73), insulin (0.73 ±0.8 µU/ml, p = 0.39), or insulin resistance (HOMA-IR) (0.19 ±0.33, p = 0.56) were seen between groups after 12 weeks. Depression and stress scores were lower with trehalose compared to the placebo group (p = 0.02 and p = 0.05, respectively), whilst the quality-of-life score was higher with trehalose compared to placebo (p = 0.03) at the end of study. Between-group differences in these indices did not reach statistical significance (–2.36 ±1.20, –2.21 ±1.39 and 3.00 ±1.76 for depression, stress, and quality-of-life score, respectively) (p > 0.05). The pro-oxidant antioxidant balance (PAB) did not differ between groups (–4.6 ±12.8, p = 0.72).
Conclusions
12 weeks of treatment with 3.3 g/day of oral trehalose significantly improves CRP as a marker of inflammation, with potential favourable effects on quality of life, depression, and stress levels, but overall glycaemic control and pro-oxidant-antioxidant balance were unaltered during this time frame. |
| first_indexed | 2024-03-09T10:48:47Z |
| format | Article |
| id | doaj.art-d50102dbde57478ab6558134f139a8ea |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:48:47Z |
| publishDate | 2023-01-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-d50102dbde57478ab6558134f139a8ea2023-12-01T09:46:10ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512023-01-011961693170010.5114/aoms/159048159048The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trialSomayyeh Hashemian0https://orcid.org/0000-0001-6760-4093Mehrnaz Shojaei1Shabnam Radbakhsh2Sorour Ashari3Maryam Matbou Riahi4Zeinab Shateri Amiri5Stephen L. Atkin6https://orcid.org/0000-0002-5887-7257Maciej Banach7https://orcid.org/0000-0001-6690-6874Mohammad Bagherniya8Seyed Ahmad Emami9Amirhossein Sahebkar10https://orcid.org/0000-0002-8656-1444Applied Biomedical Research Centre, Mashhad University of Medical Sciences, Mashhad, IranNutrition and Food Security Research Centre and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranStudent Research Committee, Mashhad University of Medical Sciences, Mashhad, IranApplied Biomedical Research Centre, Mashhad University of Medical Sciences, Mashhad, IranApplied Biomedical Research Centre, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IranSchool of Postgraduate Studies and Research, RCSI Medical University of Bahrain, Busaiteen, BahrainDepartment of Preventive Cardiology, Medical University of Lodz (MUL), Lodz, PolandNutrition and Food Security Research Centre and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranBiotechnology Research Centre, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, IranIntroduction Trehalose is a naturally occurring disaccharide of 2 glucose molecules, which has been suggested as a potential therapeutic agent to reduce blood glucose and ameliorate diabetes-related complications in type 2 diabetes (T2D). This study aimed to determine the efficacy of medium-term trehalose treatment in patients with T2D. Material and methods A double-blind, randomized, placebo-controlled trial in 40 patients with T2D was undertaken; 20 ingested trehalose 3.3 g/day and 20 placebo (sucrose), for 3 months. Parameters of glycaemic indices, high-sensitivity C-reactive protein (CRP), mood status, and quality of life were measured. Results CRP was significantly lower with trehalose treatment (–0.62 ±0.3 mg/l, p = 0.02); however, no differences in glycaemic indices of fasting blood glucose (FBG) (–7.1 ±10.7 mg/dl, p = 0.15), glycated hemoglobin (HbA1c) (–0.1 ±0.4%, p = 0.73), insulin (0.73 ±0.8 µU/ml, p = 0.39), or insulin resistance (HOMA-IR) (0.19 ±0.33, p = 0.56) were seen between groups after 12 weeks. Depression and stress scores were lower with trehalose compared to the placebo group (p = 0.02 and p = 0.05, respectively), whilst the quality-of-life score was higher with trehalose compared to placebo (p = 0.03) at the end of study. Between-group differences in these indices did not reach statistical significance (–2.36 ±1.20, –2.21 ±1.39 and 3.00 ±1.76 for depression, stress, and quality-of-life score, respectively) (p > 0.05). The pro-oxidant antioxidant balance (PAB) did not differ between groups (–4.6 ±12.8, p = 0.72). Conclusions 12 weeks of treatment with 3.3 g/day of oral trehalose significantly improves CRP as a marker of inflammation, with potential favourable effects on quality of life, depression, and stress levels, but overall glycaemic control and pro-oxidant-antioxidant balance were unaltered during this time frame.https://www.archivesofmedicalscience.com/The-effects-of-oral-trehalose-on-glycaemia-inflammation-and-quality-of-life-in-patients,159048,0,2.htmltrehalosediabetesglycaemic indiesquality of lifeantioxidantrandomized controlled trial |
| spellingShingle | Somayyeh Hashemian Mehrnaz Shojaei Shabnam Radbakhsh Sorour Ashari Maryam Matbou Riahi Zeinab Shateri Amiri Stephen L. Atkin Maciej Banach Mohammad Bagherniya Seyed Ahmad Emami Amirhossein Sahebkar The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial Archives of Medical Science trehalose diabetes glycaemic indies quality of life antioxidant randomized controlled trial |
| title | The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial |
| title_full | The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial |
| title_fullStr | The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial |
| title_full_unstemmed | The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial |
| title_short | The effects of oral trehalose on glycaemia, inflammation, and quality of life in patients with type 2 diabetes: a pilot randomized controlled trial |
| title_sort | effects of oral trehalose on glycaemia inflammation and quality of life in patients with type 2 diabetes a pilot randomized controlled trial |
| topic | trehalose diabetes glycaemic indies quality of life antioxidant randomized controlled trial |
| url | https://www.archivesofmedicalscience.com/The-effects-of-oral-trehalose-on-glycaemia-inflammation-and-quality-of-life-in-patients,159048,0,2.html |
| work_keys_str_mv | AT somayyehhashemian theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT mehrnazshojaei theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT shabnamradbakhsh theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT sorourashari theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT maryammatbouriahi theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT zeinabshateriamiri theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT stephenlatkin theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT maciejbanach theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT mohammadbagherniya theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT seyedahmademami theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT amirhosseinsahebkar theeffectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT somayyehhashemian effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT mehrnazshojaei effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT shabnamradbakhsh effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT sorourashari effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT maryammatbouriahi effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT zeinabshateriamiri effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT stephenlatkin effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT maciejbanach effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT mohammadbagherniya effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT seyedahmademami effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial AT amirhosseinsahebkar effectsoforaltrehaloseonglycaemiainflammationandqualityoflifeinpatientswithtype2diabetesapilotrandomizedcontrolledtrial |