Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study
Background and Objective: Propofol is one of the most commonly used drugs in anesthesia with the pain during an injection is a side effect of this drug. This study was conducted to compare the effect of Lidocaine, Magnesium Sulfate, and Ketamine on reducing pain caused by intravenous injection of Pr...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Golestan University of Medical Sciences
2022-03-01
|
| Series: | مجله دانشگاه علوم پزشکی گرگان |
| Subjects: | |
| Online Access: | http://goums.ac.ir/journal/article-1-4059-en.html |
| _version_ | 1828465509102780416 |
|---|---|
| author | Seyedeh Mahrokh Alinaghimaddah Payman Asghari Amir Hosein Mohammad Shafiee Fatemeh Mehravar Mohammad Aryaie |
| author_facet | Seyedeh Mahrokh Alinaghimaddah Payman Asghari Amir Hosein Mohammad Shafiee Fatemeh Mehravar Mohammad Aryaie |
| author_sort | Seyedeh Mahrokh Alinaghimaddah |
| collection | DOAJ |
| description | Background and Objective: Propofol is one of the most commonly used drugs in anesthesia with the pain during an injection is a side effect of this drug. This study was conducted to compare the effect of Lidocaine, Magnesium Sulfate, and Ketamine on reducing pain caused by intravenous injection of Propofol in patients Undergoing surgery.
Methods: In this double-blind randomized clinical trial study, 80 patients aged 18 to 65 years were randomly blocked and assigned into four groups including Lidocaine, Ketamine, Magnesium Sulfate and Normal Saline. The pain was measured with the Ambesh Score. Hemodynamic changes of patients were evaluated in 1, 3, and 5 minutes.
Results: The patients in Lidocaine, Ketamine, and Magnesium Sulfate groups with 75%, 70%, and 55%, respectively, did not feel pain after Propofol injection compared to Normal Saline group (25%) (P<0.05). The mean time trend of Systolic and diastolic blood pressure and mean arterial blood pressure between the studied groups were significant (P<0.05).
Conclusion: The use of Lidocaine or Ketamine during Propofol injection can be effective in reducing pain during injection in patients undergo surgery. |
| first_indexed | 2024-12-11T03:34:07Z |
| format | Article |
| id | doaj.art-d503ae4348004f11a268d2e0622f6de7 |
| institution | Directory Open Access Journal |
| issn | 1562-4765 2008-4080 |
| language | fas |
| last_indexed | 2024-12-11T03:34:07Z |
| publishDate | 2022-03-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشگاه علوم پزشکی گرگان |
| spelling | doaj.art-d503ae4348004f11a268d2e0622f6de72022-12-22T01:22:19ZfasGolestan University of Medical Sciencesمجله دانشگاه علوم پزشکی گرگان1562-47652008-40802022-03-012411925Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial StudySeyedeh Mahrokh Alinaghimaddah0Payman Asghari1Amir Hosein Mohammad Shafiee2Fatemeh Mehravar3Mohammad Aryaie4 Assistant Professor of Anesthesiology, Department of Anesthesiology and Critical Care, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Anesthesiologist, Imam Sajad Hospital, Mazandaran University of Medical Sciences, Ramsar, Iran. Medical Student, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Ph.D Candidate in Epidemiology, School of Public Health. Tehran University of Medical Sciences, Tehran, Iran. Assistant Professor of Epidemiology, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Background and Objective: Propofol is one of the most commonly used drugs in anesthesia with the pain during an injection is a side effect of this drug. This study was conducted to compare the effect of Lidocaine, Magnesium Sulfate, and Ketamine on reducing pain caused by intravenous injection of Propofol in patients Undergoing surgery. Methods: In this double-blind randomized clinical trial study, 80 patients aged 18 to 65 years were randomly blocked and assigned into four groups including Lidocaine, Ketamine, Magnesium Sulfate and Normal Saline. The pain was measured with the Ambesh Score. Hemodynamic changes of patients were evaluated in 1, 3, and 5 minutes. Results: The patients in Lidocaine, Ketamine, and Magnesium Sulfate groups with 75%, 70%, and 55%, respectively, did not feel pain after Propofol injection compared to Normal Saline group (25%) (P<0.05). The mean time trend of Systolic and diastolic blood pressure and mean arterial blood pressure between the studied groups were significant (P<0.05). Conclusion: The use of Lidocaine or Ketamine during Propofol injection can be effective in reducing pain during injection in patients undergo surgery.http://goums.ac.ir/journal/article-1-4059-en.htmlpropofollidocainemagnesium sulfateketaminepaingeneral anesthesia |
| spellingShingle | Seyedeh Mahrokh Alinaghimaddah Payman Asghari Amir Hosein Mohammad Shafiee Fatemeh Mehravar Mohammad Aryaie Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study مجله دانشگاه علوم پزشکی گرگان propofol lidocaine magnesium sulfate ketamine pain general anesthesia |
| title | Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study |
| title_full | Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study |
| title_fullStr | Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study |
| title_full_unstemmed | Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study |
| title_short | Effect of Lidocaine, Magnesium Sulfate and Ketamine on the Pain of Propofol Intravenous Injection in Patients Undergoing Surgery: A Clinical Trial Study |
| title_sort | effect of lidocaine magnesium sulfate and ketamine on the pain of propofol intravenous injection in patients undergoing surgery a clinical trial study |
| topic | propofol lidocaine magnesium sulfate ketamine pain general anesthesia |
| url | http://goums.ac.ir/journal/article-1-4059-en.html |
| work_keys_str_mv | AT seyedehmahrokhalinaghimaddah effectoflidocainemagnesiumsulfateandketamineonthepainofpropofolintravenousinjectioninpatientsundergoingsurgeryaclinicaltrialstudy AT paymanasghari effectoflidocainemagnesiumsulfateandketamineonthepainofpropofolintravenousinjectioninpatientsundergoingsurgeryaclinicaltrialstudy AT amirhoseinmohammadshafiee effectoflidocainemagnesiumsulfateandketamineonthepainofpropofolintravenousinjectioninpatientsundergoingsurgeryaclinicaltrialstudy AT fatemehmehravar effectoflidocainemagnesiumsulfateandketamineonthepainofpropofolintravenousinjectioninpatientsundergoingsurgeryaclinicaltrialstudy AT mohammadaryaie effectoflidocainemagnesiumsulfateandketamineonthepainofpropofolintravenousinjectioninpatientsundergoingsurgeryaclinicaltrialstudy |