Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods
Nutraceuticals and functional foods are composed of especially complex matrices, with polyphenols, carotenoids, minerals, and vitamins, among others, being the main classes of phytochemicals involved in their bioactivities. Despite their wide use, further investigations are needed to certify the pro...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1184535/full |
| _version_ | 1797770853076697088 |
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| author | Alexandru Nicolescu Alexandru Nicolescu Mihai Babotă Mihai Babotă Lillian Barros Lillian Barros Gabriele Rocchetti Luigi Lucini Corneliu Tanase Andrei Mocan Andrei Mocan Claudiu I. Bunea Gianina Crișan |
| author_facet | Alexandru Nicolescu Alexandru Nicolescu Mihai Babotă Mihai Babotă Lillian Barros Lillian Barros Gabriele Rocchetti Luigi Lucini Corneliu Tanase Andrei Mocan Andrei Mocan Claudiu I. Bunea Gianina Crișan |
| author_sort | Alexandru Nicolescu |
| collection | DOAJ |
| description | Nutraceuticals and functional foods are composed of especially complex matrices, with polyphenols, carotenoids, minerals, and vitamins, among others, being the main classes of phytochemicals involved in their bioactivities. Despite their wide use, further investigations are needed to certify the proper release of these phytochemicals into the gastrointestinal medium, where the bioaccessibility assay is one of the most frequently used method. The aim of this review was to gather and describe different methods that can be used to assess the bioaccessibility of nutraceuticals and functional foods, along with the most important factors that can impact this process. The link between simulated digestion testing of phytochemicals and their in vitro bioactivity is also discussed, with a special focus on the potential of developing nutraceuticals and functional foods from simple plant materials. The bioactive potential of certain classes of phytochemicals from nutraceuticals and functional foods is susceptible to different variations during the bioaccessibility assessment, with different factors contributing to this variability, namely the chemical composition and the nature of the matrix. Regardless of the high number of studies, the current methodology fails to assume correlations between bioaccessibility and bioactivity, and the findings of this review indicate a necessity for updated and standardized protocols. |
| first_indexed | 2024-03-12T21:28:05Z |
| format | Article |
| id | doaj.art-d5043ba71e364a86a01abb96f7a8d423 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T21:28:05Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-d5043ba71e364a86a01abb96f7a8d4232023-07-28T01:57:10ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-07-011010.3389/fnut.2023.11845351184535Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foodsAlexandru Nicolescu0Alexandru Nicolescu1Mihai Babotă2Mihai Babotă3Lillian Barros4Lillian Barros5Gabriele Rocchetti6Luigi Lucini7Corneliu Tanase8Andrei Mocan9Andrei Mocan10Claudiu I. Bunea11Gianina Crișan12Department of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaLaboratory of Chromatography, Institute of Advanced Horticulture Research of Transylvania, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Târgu Mures, Târgu Mures, RomaniaCentro de Investigação de Montanha, Instituto Politécnico de Bragança, Bragança, PortugalLaboratório Associado Para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC), Instituto Politécnico de Bragança, Bragança, PortugalDepartment of Animal Science, Food and Nutrition, Università Cattolica del Sacro Cuore, Piacenza, ItalyDepartment for Sustainable Food Process, Università Cattolica del Sacro Cuore, Piacenza, ItalyDepartment of Pharmaceutical Botany, Faculty of Pharmacy, “George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Târgu Mures, Târgu Mures, RomaniaDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaLaboratory of Chromatography, Institute of Advanced Horticulture Research of Transylvania, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, RomaniaViticulture and Oenology Department, Advanced Horticultural Research Institute of Transylvania, Faculty of Horticulture and Business in Rural Development, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Cluj-Napoca, RomaniaDepartment of Pharmaceutical Botany, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaNutraceuticals and functional foods are composed of especially complex matrices, with polyphenols, carotenoids, minerals, and vitamins, among others, being the main classes of phytochemicals involved in their bioactivities. Despite their wide use, further investigations are needed to certify the proper release of these phytochemicals into the gastrointestinal medium, where the bioaccessibility assay is one of the most frequently used method. The aim of this review was to gather and describe different methods that can be used to assess the bioaccessibility of nutraceuticals and functional foods, along with the most important factors that can impact this process. The link between simulated digestion testing of phytochemicals and their in vitro bioactivity is also discussed, with a special focus on the potential of developing nutraceuticals and functional foods from simple plant materials. The bioactive potential of certain classes of phytochemicals from nutraceuticals and functional foods is susceptible to different variations during the bioaccessibility assessment, with different factors contributing to this variability, namely the chemical composition and the nature of the matrix. Regardless of the high number of studies, the current methodology fails to assume correlations between bioaccessibility and bioactivity, and the findings of this review indicate a necessity for updated and standardized protocols.https://www.frontiersin.org/articles/10.3389/fnut.2023.1184535/fullbioaccessibilitynutraceuticalsfunctional foodsphytonutrientspolyphenolscarotenoids |
| spellingShingle | Alexandru Nicolescu Alexandru Nicolescu Mihai Babotă Mihai Babotă Lillian Barros Lillian Barros Gabriele Rocchetti Luigi Lucini Corneliu Tanase Andrei Mocan Andrei Mocan Claudiu I. Bunea Gianina Crișan Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods Frontiers in Nutrition bioaccessibility nutraceuticals functional foods phytonutrients polyphenols carotenoids |
| title | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
| title_full | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
| title_fullStr | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
| title_full_unstemmed | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
| title_short | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
| title_sort | bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
| topic | bioaccessibility nutraceuticals functional foods phytonutrients polyphenols carotenoids |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1184535/full |
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