Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions

Evolutionary relevance of single nucleotide variants within the forebrain exclusive human accelerated enhancer regions

Abstract Background Human accelerated regions (HARs) are short conserved genomic sequences that have acquired significantly more nucleotide substitutions than expected in the human lineage after divergence from chimpanzees. The fast evolution of HARs may reflect their roles in the origin of human-sp...

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Bibliographic Details
Main Authors: Hizran Khatoon, Rabail Zehra Raza, Shoaib Saleem, Fatima Batool, Saba Arshad, Muhammad Abrar, Shahid Ali, Irfan Hussain, Neil H. Shubin, Amir Ali Abbasi
Format: Article
Language:English
Published: BMC 2023-03-01
Series:BMC Molecular and Cell Biology
Subjects:
Evolution
Enhancers
Human accelerated regions
Forebrain
Archaic hominins
TFBS
Online Access:https://doi.org/10.1186/s12860-023-00474-5

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