Synthetic lethal approaches to target cancers with loss of PTEN function

Synthetic lethal approaches to target cancers with loss of PTEN function

Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene and has a role in inhibiting the oncogenic AKT signaling pathway by dephosphorylating phosphatidylinositol 3,4,5-triphosphate (PIP3) into phosphatidylinositol 4,5-bisphosphate (PIP2). The function of PTEN is regulated by different mech...

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Bibliographic Details
Main Authors: Ayse Ertay, Rob M. Ewing, Yihua Wang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-11-01
Series:Genes and Diseases
Subjects:
Cancer
PTEN
Synthetic lethality
Tumour suppressor gene
WDHD1
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223000120

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