Fibrin(ogen) Is Constitutively Expressed by Differentiated Intestinal Epithelial Cells and Mediates Wound Healing

Fibrin(ogen) Is Constitutively Expressed by Differentiated Intestinal Epithelial Cells and Mediates Wound Healing

Fibrinogen is a large molecule synthesized in the liver and released in the blood. Circulating levels of fibrinogen are upregulated after bleeding or clotting events and support wound healing. In the context of an injury, thrombin activation drives conversion of fibrinogen to fibrin. Fibrin depositi...

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Bibliographic Details
Main Authors: Amira Seltana, Gabriel Cloutier, Vilcy Reyes Nicolas, Taoufik Khalfaoui, Inga C. Teller, Nathalie Perreault, Jean-François Beaulieu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
fibrinogen
epithelial restitution
intestinal homeostasis
human
Crohn’s disease
dabigatran
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.916187/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.916187/full

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