A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation
Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. The oncocytic variant of mucoepidermoid carcinoma (OMEC) is rare and a small subset shows exclusive oncocytic morphology. Here we report an OMEC case of the parotid gland in a 74-year-old woman with exclusive oncocyte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2016-06-01
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| Series: | Rare Tumors |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/rt/article/view/6166 |
| _version_ | 1828474120937930752 |
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| author | Xiaoyan Liao Parviz Haghighi Charles S. Coffey Xiangdong Xu |
| author_facet | Xiaoyan Liao Parviz Haghighi Charles S. Coffey Xiangdong Xu |
| author_sort | Xiaoyan Liao |
| collection | DOAJ |
| description | Mucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. The oncocytic variant of mucoepidermoid carcinoma (OMEC) is rare and a small subset shows exclusive oncocytic morphology. Here we report an OMEC case of the parotid gland in a 74-year-old woman with exclusive oncocytes and rare mucocytes. The oncocytes showed diffuse nuclear positivity with p63 immunostaining. The <em>MAML2</em> translocation was present, supporting the diagnosis of OMEC. Distinguishing OMEC with exclusive oncocytes from oncocytoma and oncocytic carcinoma can be very challenging for pathologists and is critical for proper clinical management. Our experience suggests that appropriate ancillary studies, especially the <em>MAML2</em> translocation, may provide the essential evidence in difficult cases. Our literature review shows that the presence of mucocytes in an oncocytic neoplasm might be an important morphologic clue of OMEC. |
| first_indexed | 2024-12-11T05:55:42Z |
| format | Article |
| id | doaj.art-d506e3fa1f5a4fe4965f094dd17af6e2 |
| institution | Directory Open Access Journal |
| issn | 2036-3605 2036-3613 |
| language | English |
| last_indexed | 2024-12-11T05:55:42Z |
| publishDate | 2016-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Rare Tumors |
| spelling | doaj.art-d506e3fa1f5a4fe4965f094dd17af6e22022-12-22T01:18:41ZengSAGE PublishingRare Tumors2036-36052036-36132016-06-018210.4081/rt.2016.61663363A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocationXiaoyan Liao0Parviz Haghighi1Charles S. Coffey2Xiangdong Xu3Department of Pathology, University of California San Diego and VA San Diego Healthcare System, San Diego, CADepartment of Pathology, University of California San Diego and VA San Diego Healthcare System, San Diego, CADivision of Head and Neck Surgery, University of California San Diego and VA San Diego Healthcare System, San Diego, CADepartment of Pathology, University of California San Diego and VA San Diego Healthcare System, San Diego, CAMucoepidermoid carcinoma is the most common malignant tumor of the salivary gland. The oncocytic variant of mucoepidermoid carcinoma (OMEC) is rare and a small subset shows exclusive oncocytic morphology. Here we report an OMEC case of the parotid gland in a 74-year-old woman with exclusive oncocytes and rare mucocytes. The oncocytes showed diffuse nuclear positivity with p63 immunostaining. The <em>MAML2</em> translocation was present, supporting the diagnosis of OMEC. Distinguishing OMEC with exclusive oncocytes from oncocytoma and oncocytic carcinoma can be very challenging for pathologists and is critical for proper clinical management. Our experience suggests that appropriate ancillary studies, especially the <em>MAML2</em> translocation, may provide the essential evidence in difficult cases. Our literature review shows that the presence of mucocytes in an oncocytic neoplasm might be an important morphologic clue of OMEC.http://www.pagepress.org/journals/index.php/rt/article/view/6166Mucoepidermoid carcinomaoncocytic variantsalivary glandMAML2 translocationp63 immunostaining |
| spellingShingle | Xiaoyan Liao Parviz Haghighi Charles S. Coffey Xiangdong Xu A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation Rare Tumors Mucoepidermoid carcinoma oncocytic variant salivary gland MAML2 translocation p63 immunostaining |
| title | A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation |
| title_full | A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation |
| title_fullStr | A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation |
| title_full_unstemmed | A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation |
| title_short | A rare case of exclusively oncocytic mucoepidermoid carcinoma with MAML2 translocation |
| title_sort | rare case of exclusively oncocytic mucoepidermoid carcinoma with maml2 translocation |
| topic | Mucoepidermoid carcinoma oncocytic variant salivary gland MAML2 translocation p63 immunostaining |
| url | http://www.pagepress.org/journals/index.php/rt/article/view/6166 |
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