Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function

Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function

The tumor suppressive role of oridonin, an active compound extracted from Rabdosia rubescens, has been proven in several gastric cancer (GC) cell lines. The present study aimed to evaluate the effect of oridonin on another GC cell line, SNU-216, and explore the potential mechanisms. The viable cell...

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Bibliographic Details
Main Authors: Enxu Bi, Dengqiang Liu, Youxi Li, Xuying Mao, Aihua Wang, Jingtao Wang
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2018-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Oridonin
p53
Gastric cancer
Cell apoptosis
Mdm2
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200608&lng=en&tlng=en

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