SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES
Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradre...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2015-08-01
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Series: | Frontiers in Cellular Neuroscience |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00302/full |
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author | Marco eCosentino Franca eMarino Georges J.M. Maestroni |
author_facet | Marco eCosentino Franca eMarino Georges J.M. Maestroni |
author_sort | Marco eCosentino |
collection | DOAJ |
description | Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradrenaline and possibly also dopamine, which act on adrenoceptors and dopaminergic receptors expressed on hematopoietic cells and affect cell survival, proliferation, migration and engraftment ability. Remarkably, dysregulation of adrenergic fibers to the BM is associated with hematopoietic disturbances and myeloproliferative disease. Several adrenergic and dopaminergic agents are already in clinical use for non-hematological indications and with a usually favourable risk-benefit profile, and are therefore potential candidates for non-conventional modulation of hematopoiesis. |
first_indexed | 2024-12-12T15:17:22Z |
format | Article |
id | doaj.art-d5090be379244a34a6305b306e9eb0d5 |
institution | Directory Open Access Journal |
issn | 1662-5102 |
language | English |
last_indexed | 2024-12-12T15:17:22Z |
publishDate | 2015-08-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Cellular Neuroscience |
spelling | doaj.art-d5090be379244a34a6305b306e9eb0d52022-12-22T00:20:29ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-08-01910.3389/fncel.2015.00302149582SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVESMarco eCosentino0Franca eMarino1Georges J.M. Maestroni2Center for Research in Medical Pharmacology, University of InsubriaCenter for Research in Medical Pharmacology, University of InsubriaCenter for Research in Medical Pharmacology, University of InsubriaInnervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradrenaline and possibly also dopamine, which act on adrenoceptors and dopaminergic receptors expressed on hematopoietic cells and affect cell survival, proliferation, migration and engraftment ability. Remarkably, dysregulation of adrenergic fibers to the BM is associated with hematopoietic disturbances and myeloproliferative disease. Several adrenergic and dopaminergic agents are already in clinical use for non-hematological indications and with a usually favourable risk-benefit profile, and are therefore potential candidates for non-conventional modulation of hematopoiesis.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00302/fullDopamineHematopoiesisAdrenoceptorsnoradrenalineadrenalinedrug repurposing |
spellingShingle | Marco eCosentino Franca eMarino Georges J.M. Maestroni SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES Frontiers in Cellular Neuroscience Dopamine Hematopoiesis Adrenoceptors noradrenaline adrenaline drug repurposing |
title | SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES |
title_full | SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES |
title_fullStr | SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES |
title_full_unstemmed | SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES |
title_short | SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES |
title_sort | sympathoadrenergic modulation of hematopoiesis a review of available evidence and of therapeutic perspectives |
topic | Dopamine Hematopoiesis Adrenoceptors noradrenaline adrenaline drug repurposing |
url | http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00302/full |
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