SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES

Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradre...

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Main Authors: Marco eCosentino, Franca eMarino, Georges J.M. Maestroni
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00302/full
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author Marco eCosentino
Franca eMarino
Georges J.M. Maestroni
author_facet Marco eCosentino
Franca eMarino
Georges J.M. Maestroni
author_sort Marco eCosentino
collection DOAJ
description Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradrenaline and possibly also dopamine, which act on adrenoceptors and dopaminergic receptors expressed on hematopoietic cells and affect cell survival, proliferation, migration and engraftment ability. Remarkably, dysregulation of adrenergic fibers to the BM is associated with hematopoietic disturbances and myeloproliferative disease. Several adrenergic and dopaminergic agents are already in clinical use for non-hematological indications and with a usually favourable risk-benefit profile, and are therefore potential candidates for non-conventional modulation of hematopoiesis.
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spelling doaj.art-d5090be379244a34a6305b306e9eb0d52022-12-22T00:20:29ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022015-08-01910.3389/fncel.2015.00302149582SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVESMarco eCosentino0Franca eMarino1Georges J.M. Maestroni2Center for Research in Medical Pharmacology, University of InsubriaCenter for Research in Medical Pharmacology, University of InsubriaCenter for Research in Medical Pharmacology, University of InsubriaInnervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradrenaline and possibly also dopamine, which act on adrenoceptors and dopaminergic receptors expressed on hematopoietic cells and affect cell survival, proliferation, migration and engraftment ability. Remarkably, dysregulation of adrenergic fibers to the BM is associated with hematopoietic disturbances and myeloproliferative disease. Several adrenergic and dopaminergic agents are already in clinical use for non-hematological indications and with a usually favourable risk-benefit profile, and are therefore potential candidates for non-conventional modulation of hematopoiesis.http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00302/fullDopamineHematopoiesisAdrenoceptorsnoradrenalineadrenalinedrug repurposing
spellingShingle Marco eCosentino
Franca eMarino
Georges J.M. Maestroni
SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES
Frontiers in Cellular Neuroscience
Dopamine
Hematopoiesis
Adrenoceptors
noradrenaline
adrenaline
drug repurposing
title SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES
title_full SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES
title_fullStr SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES
title_full_unstemmed SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES
title_short SYMPATHOADRENERGIC MODULATION OF HEMATOPOIESIS: A REVIEW OF AVAILABLE EVIDENCE AND OF THERAPEUTIC PERSPECTIVES
title_sort sympathoadrenergic modulation of hematopoiesis a review of available evidence and of therapeutic perspectives
topic Dopamine
Hematopoiesis
Adrenoceptors
noradrenaline
adrenaline
drug repurposing
url http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00302/full
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AT francaemarino sympathoadrenergicmodulationofhematopoiesisareviewofavailableevidenceandoftherapeuticperspectives
AT georgesjmmaestroni sympathoadrenergicmodulationofhematopoiesisareviewofavailableevidenceandoftherapeuticperspectives