Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (<i>S</i>)-1-(3-Methoxyphenyl)ethylamine
An integrated biocatalysis-crystallization concept was developed for the continuous amine transaminase-catalyzed synthesis of (<i>S</i>)-1-(3-methoxyphenyl)ethylamine, which is a valuable intermediate for the synthesis of rivastigmine, a highly potent drug for the treatment of early stag...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Crystals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4352/10/5/345 |
| _version_ | 1797569527811145728 |
|---|---|
| author | Dennis Hülsewede Erik Temmel Peter Kumm Jan von Langermann |
| author_facet | Dennis Hülsewede Erik Temmel Peter Kumm Jan von Langermann |
| author_sort | Dennis Hülsewede |
| collection | DOAJ |
| description | An integrated biocatalysis-crystallization concept was developed for the continuous amine transaminase-catalyzed synthesis of (<i>S</i>)-1-(3-methoxyphenyl)ethylamine, which is a valuable intermediate for the synthesis of rivastigmine, a highly potent drug for the treatment of early stage Alzheimer’s disease. The three-part vessel system developed for this purpose consists of a membrane reactor for the continuous synthesis of the product amine, a saturator vessel for the continuous supply of the amine donor isopropylammonium and the precipitating reagent 3,3-diphenylpropionate and a crystallizer in which the product amine can continuously precipitate as (<i>S</i>)-1-(3-methoxyphenyl)ethylammonium-3,3-diphenylpropionate. |
| first_indexed | 2024-03-10T20:12:50Z |
| format | Article |
| id | doaj.art-d50a446ecaaf4e22864470fd24e415db |
| institution | Directory Open Access Journal |
| issn | 2073-4352 |
| language | English |
| last_indexed | 2024-03-10T20:12:50Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Crystals |
| spelling | doaj.art-d50a446ecaaf4e22864470fd24e415db2023-11-19T22:50:17ZengMDPI AGCrystals2073-43522020-04-0110534510.3390/cryst10050345Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (<i>S</i>)-1-(3-Methoxyphenyl)ethylamineDennis Hülsewede0Erik Temmel1Peter Kumm2Jan von Langermann3Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, Albert-Einstein-Str. 3A, 18059 Rostock, GermanySulzer Chemtech Ltd., Gewerbestraße 28, 4123 Allschwil, SwitzerlandBiocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, Albert-Einstein-Str. 3A, 18059 Rostock, GermanyBiocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, Albert-Einstein-Str. 3A, 18059 Rostock, GermanyAn integrated biocatalysis-crystallization concept was developed for the continuous amine transaminase-catalyzed synthesis of (<i>S</i>)-1-(3-methoxyphenyl)ethylamine, which is a valuable intermediate for the synthesis of rivastigmine, a highly potent drug for the treatment of early stage Alzheimer’s disease. The three-part vessel system developed for this purpose consists of a membrane reactor for the continuous synthesis of the product amine, a saturator vessel for the continuous supply of the amine donor isopropylammonium and the precipitating reagent 3,3-diphenylpropionate and a crystallizer in which the product amine can continuously precipitate as (<i>S</i>)-1-(3-methoxyphenyl)ethylammonium-3,3-diphenylpropionate.https://www.mdpi.com/2073-4352/10/5/345aminebiocatalysisenzymeprocess intensificationcrystallizationenantioselective |
| spellingShingle | Dennis Hülsewede Erik Temmel Peter Kumm Jan von Langermann Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (<i>S</i>)-1-(3-Methoxyphenyl)ethylamine Crystals amine biocatalysis enzyme process intensification crystallization enantioselective |
| title | Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (<i>S</i>)-1-(3-Methoxyphenyl)ethylamine |
| title_full | Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (<i>S</i>)-1-(3-Methoxyphenyl)ethylamine |
| title_fullStr | Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (<i>S</i>)-1-(3-Methoxyphenyl)ethylamine |
| title_full_unstemmed | Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (<i>S</i>)-1-(3-Methoxyphenyl)ethylamine |
| title_short | Concept Study for an Integrated Reactor-Crystallizer Process for the Continuous Biocatalytic Synthesis of (<i>S</i>)-1-(3-Methoxyphenyl)ethylamine |
| title_sort | concept study for an integrated reactor crystallizer process for the continuous biocatalytic synthesis of i s i 1 3 methoxyphenyl ethylamine |
| topic | amine biocatalysis enzyme process intensification crystallization enantioselective |
| url | https://www.mdpi.com/2073-4352/10/5/345 |
| work_keys_str_mv | AT dennishulsewede conceptstudyforanintegratedreactorcrystallizerprocessforthecontinuousbiocatalyticsynthesisofisi13methoxyphenylethylamine AT eriktemmel conceptstudyforanintegratedreactorcrystallizerprocessforthecontinuousbiocatalyticsynthesisofisi13methoxyphenylethylamine AT peterkumm conceptstudyforanintegratedreactorcrystallizerprocessforthecontinuousbiocatalyticsynthesisofisi13methoxyphenylethylamine AT janvonlangermann conceptstudyforanintegratedreactorcrystallizerprocessforthecontinuousbiocatalyticsynthesisofisi13methoxyphenylethylamine |