Crosstalk between Autophagy and RLR Signaling
Autophagy plays a homeostatic role in regulating cellular metabolism by degrading unwanted intracellular materials and acts as a host defense mechanism by eliminating infecting pathogens, such as viruses. Upon viral infection, host cells often activate retinoic acid-inducible gene I (RIG-I)-like rec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/6/956 |
| _version_ | 1827750823027802112 |
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| author | Po-Yuan Ke |
| author_facet | Po-Yuan Ke |
| author_sort | Po-Yuan Ke |
| collection | DOAJ |
| description | Autophagy plays a homeostatic role in regulating cellular metabolism by degrading unwanted intracellular materials and acts as a host defense mechanism by eliminating infecting pathogens, such as viruses. Upon viral infection, host cells often activate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling to induce the transcription of type I interferons, thus establishing the first line of the innate antiviral response. In recent years, numerous studies have shown that virus-mediated autophagy activation may benefit viral replication through different actions on host cellular processes, including the modulation of RLR-mediated innate immunity. Here, an overview of the functional molecules and regulatory mechanism of the RLR antiviral immune response as well as autophagy is presented. Moreover, a summary of the current knowledge on the biological role of autophagy in regulating RLR antiviral signaling is provided. The molecular mechanisms underlying the crosstalk between autophagy and RLR innate immunity are also discussed. |
| first_indexed | 2024-03-11T06:48:02Z |
| format | Article |
| id | doaj.art-d50aa3c4133c456e99e2a2e35bcf64b4 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T06:48:02Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d50aa3c4133c456e99e2a2e35bcf64b42023-11-17T10:14:14ZengMDPI AGCells2073-44092023-03-0112695610.3390/cells12060956Crosstalk between Autophagy and RLR SignalingPo-Yuan Ke0Department of Biochemistry & Molecular Biology, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, TaiwanAutophagy plays a homeostatic role in regulating cellular metabolism by degrading unwanted intracellular materials and acts as a host defense mechanism by eliminating infecting pathogens, such as viruses. Upon viral infection, host cells often activate retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) signaling to induce the transcription of type I interferons, thus establishing the first line of the innate antiviral response. In recent years, numerous studies have shown that virus-mediated autophagy activation may benefit viral replication through different actions on host cellular processes, including the modulation of RLR-mediated innate immunity. Here, an overview of the functional molecules and regulatory mechanism of the RLR antiviral immune response as well as autophagy is presented. Moreover, a summary of the current knowledge on the biological role of autophagy in regulating RLR antiviral signaling is provided. The molecular mechanisms underlying the crosstalk between autophagy and RLR innate immunity are also discussed.https://www.mdpi.com/2073-4409/12/6/956autophagyRLRselective autophagyantiviral responseinnate immunity |
| spellingShingle | Po-Yuan Ke Crosstalk between Autophagy and RLR Signaling Cells autophagy RLR selective autophagy antiviral response innate immunity |
| title | Crosstalk between Autophagy and RLR Signaling |
| title_full | Crosstalk between Autophagy and RLR Signaling |
| title_fullStr | Crosstalk between Autophagy and RLR Signaling |
| title_full_unstemmed | Crosstalk between Autophagy and RLR Signaling |
| title_short | Crosstalk between Autophagy and RLR Signaling |
| title_sort | crosstalk between autophagy and rlr signaling |
| topic | autophagy RLR selective autophagy antiviral response innate immunity |
| url | https://www.mdpi.com/2073-4409/12/6/956 |
| work_keys_str_mv | AT poyuanke crosstalkbetweenautophagyandrlrsignaling |