The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee Osteoarthritis
<p><strong><em>Introduction: </em></strong><em>Knee<strong> </strong>Osteoarthritis (KOA) is characterized by wear, tear, and it's a slowly progressive loss of cartilage, that becomes finally disabling. KOA is one of the most analyzed diseases by...
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| Format: | Article |
| Language: | English |
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EduSoft publishing
2023-06-01
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| Series: | Brain: Broad Research in Artificial Intelligence and Neuroscience |
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| Online Access: | https://www.edusoft.ro/brain/index.php/brain/article/view/1407 |
| _version_ | 1797335674216513536 |
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| author | Ilie Onu Ioana Buculei Claudiu Gabriel Ionescu Daniela Nicoleta Stanca Bogdan Voicu Daniel-Andrei Iordan |
| author_facet | Ilie Onu Ioana Buculei Claudiu Gabriel Ionescu Daniela Nicoleta Stanca Bogdan Voicu Daniel-Andrei Iordan |
| author_sort | Ilie Onu |
| collection | DOAJ |
| description | <p><strong><em>Introduction: </em></strong><em>Knee<strong> </strong>Osteoarthritis (KOA) is characterized by wear, tear, and it's a slowly progressive loss of cartilage, that becomes finally disabling. KOA is one of the most analyzed diseases by many medical specialties such as rheumatology, orthopedics, rehabilitation medicine, and physiotherapy. Major symptoms of KOA such as pain, dysfunction, and chronic low-grade inflammation will decrease the quality of life and eventually lead to locomotor disability. Since there are no effective ways to limit KOA progression, involvement of the endocannabinoid system (ECS) may be a non-pharmacological therapeutic alternative in the management of this disease. This study debate aspects of ways to modulate the ECS in KOA, using physiotherapeutic (PT) means such as TENS electroanalgesia, LASER biostimulation, and physical exercises with analgesic effects.</em></p><p><strong><em>Materials and Methods: </em></strong><em>In the study, we included 82 sources, with the following keywords in the title: knee osteoarthritis, cannabidiol, endocannabinoid, inflammatory pain, analgesia, neuropathic pain, physiotherapy, electrotherapy, and LASER. To perform this review, we searched for the most relevant articles in the field of medicine and physiotherapy in 7 international databases applying inclusion and exclusion criteria.</em></p><p><strong><em>Results: </em></strong><em>The application of TENS currents in certain doses and frequencies together with LASER biostimulation stimulates the production of endocannabinoids thus controlling pain, and stimulating the ECS. Physical exercise has an antioxidant, and anti-inflammatory role and stimulates the release of endogenous opioids.</em></p><p><strong><em>Conclusions: </em></strong><em>The results obtained from this meta-analysis may contribute to paradigm shifts in clinical practice related to the treatment of pain by PT. TENS, LASER, and physical exercise are effective clinical tool that limits chronic inflammation and pain by involving the ECS. More studies are needed to understand endocannabinoid system involvements in KOA, and that will inspire medical doctors and physiotherapists to improve long-term treatment strategies.</em></p> |
| first_indexed | 2024-03-08T08:41:45Z |
| format | Article |
| id | doaj.art-d50c09662a6a428f8aa533c19e9c0c0c |
| institution | Directory Open Access Journal |
| issn | 2067-3957 |
| language | English |
| last_indexed | 2024-03-08T08:41:45Z |
| publishDate | 2023-06-01 |
| publisher | EduSoft publishing |
| record_format | Article |
| series | Brain: Broad Research in Artificial Intelligence and Neuroscience |
| spelling | doaj.art-d50c09662a6a428f8aa533c19e9c0c0c2024-02-01T18:00:43ZengEduSoft publishingBrain: Broad Research in Artificial Intelligence and Neuroscience2067-39572023-06-011423033201211The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee OsteoarthritisIlie Onu0Ioana Buculei1Claudiu Gabriel Ionescu2Daniela Nicoleta Stanca3Bogdan Voicu4Daniel-Andrei Iordan5Department of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iaşi, 700454 Iaşi, Romania;Doctoral School of the Faculty of Chemical Engineering and Environmental Protection “Cristofor Simionescu”, Technical University “Gheorghe Asachi” Iaşi, 700050 Iaşi, Romania; Department of Physiotherapy, Micromedica Clinic, 610119 Piatra Neamţ, RomaniaDepartment of Biomedical Sciences, Faculty of Medical Bioengineering, University of Medicine and Pharmacy “Grigore T. Popa” Iaşi, 700454 Iaşi, Romania;Department of Medical Psychology, Faculty of General Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 050474 Bucharest, RomaniaKineto Dema Training, Bucureşti, RomaniaOKF Medical Center, Târgu Mureş, RomaniaDepartment of Individual Sports and Kinetotherapy, Faculty of Physical Education and Sport, “Dunărea de Jos” University of Galaţi, 800008 Galaţi, România; Center of Physical Therapy and Rehabilitation, “Dunărea de Jos” University of Galaţi, 800008 Galaţi, România<p><strong><em>Introduction: </em></strong><em>Knee<strong> </strong>Osteoarthritis (KOA) is characterized by wear, tear, and it's a slowly progressive loss of cartilage, that becomes finally disabling. KOA is one of the most analyzed diseases by many medical specialties such as rheumatology, orthopedics, rehabilitation medicine, and physiotherapy. Major symptoms of KOA such as pain, dysfunction, and chronic low-grade inflammation will decrease the quality of life and eventually lead to locomotor disability. Since there are no effective ways to limit KOA progression, involvement of the endocannabinoid system (ECS) may be a non-pharmacological therapeutic alternative in the management of this disease. This study debate aspects of ways to modulate the ECS in KOA, using physiotherapeutic (PT) means such as TENS electroanalgesia, LASER biostimulation, and physical exercises with analgesic effects.</em></p><p><strong><em>Materials and Methods: </em></strong><em>In the study, we included 82 sources, with the following keywords in the title: knee osteoarthritis, cannabidiol, endocannabinoid, inflammatory pain, analgesia, neuropathic pain, physiotherapy, electrotherapy, and LASER. To perform this review, we searched for the most relevant articles in the field of medicine and physiotherapy in 7 international databases applying inclusion and exclusion criteria.</em></p><p><strong><em>Results: </em></strong><em>The application of TENS currents in certain doses and frequencies together with LASER biostimulation stimulates the production of endocannabinoids thus controlling pain, and stimulating the ECS. Physical exercise has an antioxidant, and anti-inflammatory role and stimulates the release of endogenous opioids.</em></p><p><strong><em>Conclusions: </em></strong><em>The results obtained from this meta-analysis may contribute to paradigm shifts in clinical practice related to the treatment of pain by PT. TENS, LASER, and physical exercise are effective clinical tool that limits chronic inflammation and pain by involving the ECS. More studies are needed to understand endocannabinoid system involvements in KOA, and that will inspire medical doctors and physiotherapists to improve long-term treatment strategies.</em></p>https://www.edusoft.ro/brain/index.php/brain/article/view/1407knee osteoarthritis, endocannabinoid system, tens, laser, physical exercise. |
| spellingShingle | Ilie Onu Ioana Buculei Claudiu Gabriel Ionescu Daniela Nicoleta Stanca Bogdan Voicu Daniel-Andrei Iordan The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee Osteoarthritis Brain: Broad Research in Artificial Intelligence and Neuroscience knee osteoarthritis, endocannabinoid system, tens, laser, physical exercise. |
| title | The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee Osteoarthritis |
| title_full | The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee Osteoarthritis |
| title_fullStr | The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee Osteoarthritis |
| title_full_unstemmed | The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee Osteoarthritis |
| title_short | The Endocannabinoid System a Turning Point in Optimizing Physiotherapy Procedures in Knee Osteoarthritis |
| title_sort | endocannabinoid system a turning point in optimizing physiotherapy procedures in knee osteoarthritis |
| topic | knee osteoarthritis, endocannabinoid system, tens, laser, physical exercise. |
| url | https://www.edusoft.ro/brain/index.php/brain/article/view/1407 |
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