Bacteroides xylanisolvens possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein diet
IntroductionHyperuricemia is widespread in humans and birds which is a necessary physiological factor leading to gout. Studies have shown an inextricable relationship between gut microbiota and hyperuricemia. This study explored the association between intestinal flora and hyperuricemia in Goslings....
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1173856/full |
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| author | Ning Song Mingze Wang Guangxu Zhong Kunpeng Zhu Pengju Chen Pengju Chen Naisheng Zhang Xiaobo Liu Wenlong Zhang |
| author_facet | Ning Song Mingze Wang Guangxu Zhong Kunpeng Zhu Pengju Chen Pengju Chen Naisheng Zhang Xiaobo Liu Wenlong Zhang |
| author_sort | Ning Song |
| collection | DOAJ |
| description | IntroductionHyperuricemia is widespread in humans and birds which is a necessary physiological factor leading to gout. Studies have shown an inextricable relationship between gut microbiota and hyperuricemia. This study explored the association between intestinal flora and hyperuricemia in Goslings.Methods and resultsThe hyperuricemia model was established in gosling by a high protein diet (HPD). 16S rDNA sequencing showed that the cecal microbiota differed significantly between the HPD and control groups (fed with the normal protein). The abundance of Firmicutes was higher in the HPD group, while the Bacteroidetes were lower than in controls. To investigate the role of intestinal flora in hyperuricemia, the cecum microbiotas from the HPD group and the control group were transplanted to the newly born goslings by gavage. The serum uric acid levels of the goslings that transplanted the cecal microbiota of the HPD group were significantly higher than the goslings that transplanted the cecal microbiota of the controls. Furthermore, the transplantation of cecal microbiota also affects the production and excretion of uric acid in goslings. Then we identify the gut bacterium Bacteroides xylanisolvens as an effective anti-hyperuricemia in the Goslings. B. xylanisolvens reduces serum uric acid concentrations in hyperuricemia in the Goslings' model, and it can up-regulation ABCG2 mRNA expression in the kidney and down-regulation XDH mRNA expression in the liver.DiscussionThe intestinal flora acts as a novel target for the therapeutic approach to hyperuricemia and gout, suggest Bacteroides xylanisolvens is a possible route to therapy for hyperuricemia and gout in goslings. |
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| id | doaj.art-d50c3348368545bd86f5b38a7be4f92d |
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| issn | 1664-302X |
| language | English |
| last_indexed | 2024-03-13T02:14:25Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-d50c3348368545bd86f5b38a7be4f92d2023-06-30T18:54:18ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-06-011410.3389/fmicb.2023.11738561173856Bacteroides xylanisolvens possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein dietNing Song0Mingze Wang1Guangxu Zhong2Kunpeng Zhu3Pengju Chen4Pengju Chen5Naisheng Zhang6Xiaobo Liu7Wenlong Zhang8Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaHenan Institute of Modern Chinese Veterinary Medicine, Zhengzhou, Henan, ChinaShandong Xindehui Biotechnology Company Ltd., Yuncheng, Shandong, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaSchool of Life Science, Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaIntroductionHyperuricemia is widespread in humans and birds which is a necessary physiological factor leading to gout. Studies have shown an inextricable relationship between gut microbiota and hyperuricemia. This study explored the association between intestinal flora and hyperuricemia in Goslings.Methods and resultsThe hyperuricemia model was established in gosling by a high protein diet (HPD). 16S rDNA sequencing showed that the cecal microbiota differed significantly between the HPD and control groups (fed with the normal protein). The abundance of Firmicutes was higher in the HPD group, while the Bacteroidetes were lower than in controls. To investigate the role of intestinal flora in hyperuricemia, the cecum microbiotas from the HPD group and the control group were transplanted to the newly born goslings by gavage. The serum uric acid levels of the goslings that transplanted the cecal microbiota of the HPD group were significantly higher than the goslings that transplanted the cecal microbiota of the controls. Furthermore, the transplantation of cecal microbiota also affects the production and excretion of uric acid in goslings. Then we identify the gut bacterium Bacteroides xylanisolvens as an effective anti-hyperuricemia in the Goslings. B. xylanisolvens reduces serum uric acid concentrations in hyperuricemia in the Goslings' model, and it can up-regulation ABCG2 mRNA expression in the kidney and down-regulation XDH mRNA expression in the liver.DiscussionThe intestinal flora acts as a novel target for the therapeutic approach to hyperuricemia and gout, suggest Bacteroides xylanisolvens is a possible route to therapy for hyperuricemia and gout in goslings.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1173856/fullintestinal florahyperuricemiauric acidBacteroides xylanisolvensgoslings |
| spellingShingle | Ning Song Mingze Wang Guangxu Zhong Kunpeng Zhu Pengju Chen Pengju Chen Naisheng Zhang Xiaobo Liu Wenlong Zhang Bacteroides xylanisolvens possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein diet Frontiers in Microbiology intestinal flora hyperuricemia uric acid Bacteroides xylanisolvens goslings |
| title | Bacteroides xylanisolvens possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein diet |
| title_full | Bacteroides xylanisolvens possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein diet |
| title_fullStr | Bacteroides xylanisolvens possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein diet |
| title_full_unstemmed | Bacteroides xylanisolvens possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein diet |
| title_short | Bacteroides xylanisolvens possesses a potent anti-hyperuricemia effect in goslings fed on a high-protein diet |
| title_sort | bacteroides xylanisolvens possesses a potent anti hyperuricemia effect in goslings fed on a high protein diet |
| topic | intestinal flora hyperuricemia uric acid Bacteroides xylanisolvens goslings |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1173856/full |
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