Personalized treatment options of refractory and relapsed medulloblastoma in children: literature review
Medulloblastoma (MB) is the most common malignant tumor of the central nervous system in pediatric patients. Despite the complex anticancer therapy approach, refractory and relapsing forms of the disease remain fatal in most cases and account for approximately 30%. To date, repeated surgery, radiati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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IP Habib O.N.
2023-12-01
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| Series: | Современная онкология |
| Subjects: | |
| Online Access: | https://modernonco.orscience.ru/1815-1434/article/viewFile/492325/pdf |
| _version_ | 1797290166222585856 |
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| author | Yulia V. Dinikina Olga G. Zheludkova Margarita B. Belogurova Dmitry M. Spelnikov Nikolai N. Osipov Irina L. Nikitina |
| author_facet | Yulia V. Dinikina Olga G. Zheludkova Margarita B. Belogurova Dmitry M. Spelnikov Nikolai N. Osipov Irina L. Nikitina |
| author_sort | Yulia V. Dinikina |
| collection | DOAJ |
| description | Medulloblastoma (MB) is the most common malignant tumor of the central nervous system in pediatric patients. Despite the complex anticancer therapy approach, refractory and relapsing forms of the disease remain fatal in most cases and account for approximately 30%. To date, repeated surgery, radiation, and chemotherapy can be used as life-prolonging treatment options; nevertheless, it should be emphasized that there are no standardized approaches based on existing data of molecular variants of MB. It is obvious that only a deep understanding of the biological mechanisms in association with clinical aspects in refractory and relapsing forms of MB would make it possible to personalize second- and subsequent-line therapy in order to achieve maximum efficiency and minimize early and long-term toxicity. The article presents the current understanding of prognostic factors in relapsed/refractory forms of MB, methods of modern diagnostics, as well as existing and perspective treatment options based on the biological and clinical aspects of the disease. |
| first_indexed | 2024-03-07T19:16:33Z |
| format | Article |
| id | doaj.art-d50cd51594df41fab19a9c9c1c3f8c44 |
| institution | Directory Open Access Journal |
| issn | 1815-1434 1815-1442 |
| language | Russian |
| last_indexed | 2024-03-07T19:16:33Z |
| publishDate | 2023-12-01 |
| publisher | IP Habib O.N. |
| record_format | Article |
| series | Современная онкология |
| spelling | doaj.art-d50cd51594df41fab19a9c9c1c3f8c442024-02-29T13:31:29ZrusIP Habib O.N.Современная онкология1815-14341815-14422023-12-0125445446510.26442/18151434.2023.4.20252179525Personalized treatment options of refractory and relapsed medulloblastoma in children: literature reviewYulia V. Dinikina0https://orcid.org/0000-0002-2003-0982Olga G. Zheludkova1https://orcid.org/0000-0002-8607-3635Margarita B. Belogurova2https://orcid.org/0000-0002-7471-7181Dmitry M. Spelnikov3https://orcid.org/0000-0002-3475-1780Nikolai N. Osipov4https://orcid.org/0000-0002-5391-3917Irina L. Nikitina5https://orcid.org/0000-0003-4013-0785Almazov National Medical Research CentreVoino-Yasenetskiy Scientific and Practical Center of Specialized Healthcare for ChildrenAlmazov National Medical Research CentreDarwin Tech LabsSaint Petersburg Department of Steklov Mathematical InstituteAlmazov National Medical Research CentreMedulloblastoma (MB) is the most common malignant tumor of the central nervous system in pediatric patients. Despite the complex anticancer therapy approach, refractory and relapsing forms of the disease remain fatal in most cases and account for approximately 30%. To date, repeated surgery, radiation, and chemotherapy can be used as life-prolonging treatment options; nevertheless, it should be emphasized that there are no standardized approaches based on existing data of molecular variants of MB. It is obvious that only a deep understanding of the biological mechanisms in association with clinical aspects in refractory and relapsing forms of MB would make it possible to personalize second- and subsequent-line therapy in order to achieve maximum efficiency and minimize early and long-term toxicity. The article presents the current understanding of prognostic factors in relapsed/refractory forms of MB, methods of modern diagnostics, as well as existing and perspective treatment options based on the biological and clinical aspects of the disease.https://modernonco.orscience.ru/1815-1434/article/viewFile/492325/pdfchildren oncologymedulloblastomarelapseprecision medicinetargeted therapymetronomic chemotherapy |
| spellingShingle | Yulia V. Dinikina Olga G. Zheludkova Margarita B. Belogurova Dmitry M. Spelnikov Nikolai N. Osipov Irina L. Nikitina Personalized treatment options of refractory and relapsed medulloblastoma in children: literature review Современная онкология children oncology medulloblastoma relapse precision medicine targeted therapy metronomic chemotherapy |
| title | Personalized treatment options of refractory and relapsed medulloblastoma in children: literature review |
| title_full | Personalized treatment options of refractory and relapsed medulloblastoma in children: literature review |
| title_fullStr | Personalized treatment options of refractory and relapsed medulloblastoma in children: literature review |
| title_full_unstemmed | Personalized treatment options of refractory and relapsed medulloblastoma in children: literature review |
| title_short | Personalized treatment options of refractory and relapsed medulloblastoma in children: literature review |
| title_sort | personalized treatment options of refractory and relapsed medulloblastoma in children literature review |
| topic | children oncology medulloblastoma relapse precision medicine targeted therapy metronomic chemotherapy |
| url | https://modernonco.orscience.ru/1815-1434/article/viewFile/492325/pdf |
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