Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair
The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure of the yeast TFIIH/Rad4–Rad23-Rad33 complex b...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23684-x |
| _version_ | 1818736047599648768 |
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| author | Trevor van Eeuwen Yoonjung Shim Hee Jong Kim Tingting Zhao Shrabani Basu Benjamin A. Garcia Craig D. Kaplan Jung-Hyun Min Kenji Murakami |
| author_facet | Trevor van Eeuwen Yoonjung Shim Hee Jong Kim Tingting Zhao Shrabani Basu Benjamin A. Garcia Craig D. Kaplan Jung-Hyun Min Kenji Murakami |
| author_sort | Trevor van Eeuwen |
| collection | DOAJ |
| description | The conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure of the yeast TFIIH/Rad4–Rad23-Rad33 complex bound to a DNA containing a single carcinogen-DNA adduct. |
| first_indexed | 2024-12-18T00:30:56Z |
| format | Article |
| id | doaj.art-d50d4da2dfcb426987c2cc95413c64ea |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:30:56Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d50d4da2dfcb426987c2cc95413c64ea2022-12-21T21:27:09ZengNature PortfolioNature Communications2041-17232021-06-0112111710.1038/s41467-021-23684-xCryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repairTrevor van Eeuwen0Yoonjung Shim1Hee Jong Kim2Tingting Zhao3Shrabani Basu4Benjamin A. Garcia5Craig D. Kaplan6Jung-Hyun Min7Kenji Murakami8Department of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaDepartment of Chemistry and Biochemistry, Baylor UniversityDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaDepartment of Biological Sciences, University of PittsburghDepartment of Biological Sciences, University of PittsburghDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaDepartment of Biological Sciences, University of PittsburghDepartment of Chemistry and Biochemistry, Baylor UniversityDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of PennsylvaniaThe conserved eukaryotic nucleotide excision repair (NER) pathway protects the genome from a wide variety of environmentally induced DNA lesions. Here, the authors provide insights into how NER is initiated on lesions by determining the cryo-EM structure of the yeast TFIIH/Rad4–Rad23-Rad33 complex bound to a DNA containing a single carcinogen-DNA adduct.https://doi.org/10.1038/s41467-021-23684-x |
| spellingShingle | Trevor van Eeuwen Yoonjung Shim Hee Jong Kim Tingting Zhao Shrabani Basu Benjamin A. Garcia Craig D. Kaplan Jung-Hyun Min Kenji Murakami Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair Nature Communications |
| title | Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair |
| title_full | Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair |
| title_fullStr | Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair |
| title_full_unstemmed | Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair |
| title_short | Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair |
| title_sort | cryo em structure of tfiih rad4 rad23 rad33 in damaged dna opening in nucleotide excision repair |
| url | https://doi.org/10.1038/s41467-021-23684-x |
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